Skip to main content
SpringerLink
Log in

Familial Cancer Syndromes

  • Chapter
Molecular Genetic Pathology

  • 2108 Accesses

Abstract

In 2006, about 1.4 million new cancers were diagnosed in the United States. This includes 1 million non-melanomatous skin cancers. Almost 10 million Americans are alive today with a diagnosis of cancer. The likelihood that any given person has a family history of cancer is, therefore, quite high. The majority of these cases are due to complex environmental factors or chance. However, in 5–10% of cases this is due to a heritable familial cancer syndrome.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Suggested Reading

  • Abdel-Rahman WM, Peltomaki P. Molecular basis and diagnosis of hereditary colorectal cancers. Ann Med. 2004;36:379–388.

    Article  CAS  PubMed  Google Scholar 

  • Abdel-Rahman WM, Mecklin JP, Peltomaki P. The genetics of HNPCC: application to diagnosis and screening. Crit Rev Oncol Hematol. 2006;58:208–220.

    Article  PubMed  Google Scholar 

  • Bornstein SR, Gimenez-Roqueplo AP. Genetic testing in pheochromocytoma: increasing importance for clinical decision making. Ann NY Acad Sci. 2006;1073:94–103.

    Article  PubMed  Google Scholar 

  • Carney JA. Familial multiple endocrine neoplasia: the first 100 years. Am J Surg Pathol. 2005;29:254–274.

    Article  PubMed  Google Scholar 

  • Frank TS, Deffenbaugh AM, Reid JE, et al. Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: analysis of 10,000 individuals. J Clin Oncol. 2002;20:1480–1490.

    Article  CAS  PubMed  Google Scholar 

  • Garber J, Offit K. Hereditary cancer predisposition syndromes. J Clin Oncol. 2005;23:276–292.

    Article  PubMed  Google Scholar 

  • Hemminki K, Eng C. Clinical genetic counselling for familial cancers requires reliable data on familial cancer risks and general action plans. J Med Genet. 2004;41:801–807.

    Article  CAS  PubMed  Google Scholar 

  • Kaz AM, Brentnall TA. Genetic testing for colon cancer. Nat Clin Pract Gastroenterol Hepatol. 2006;3:670–679.

    Article  CAS  PubMed  Google Scholar 

  • Khoury-Collado F, Bombard AT. Hereditary breast and ovarian cancer: what the primary care physician should know. Obstet Gynecol Surv. 2004; 59:537–542.

    Article  PubMed  Google Scholar 

  • Lenz HJ. First Amsterdam, then Bethesda, now Melbourne? J Clin Oncol. 2005;23:6445–6449.

    Article  PubMed  Google Scholar 

  • Lackner C, Hoefler C. Critical issues in the identification and management of patients with hereditary non-polyposis colorectal cancer. Eur J Gastroenterol Hepatol. 2005;17:317–322.

    Article  CAS  PubMed  Google Scholar 

  • Lindor NM, Greene MH. The concise handbook of family cancer syndromes. Mayo Familial Cancer Program. J Natl Cancer Inst. 1998;90:1039–1071.

    Article  CAS  PubMed  Google Scholar 

  • Lux MP, Fasching PA, Beckmann MW. Hereditary breast and ovarian cancer: review and future perspectives. J Mol Med. 2006;84:16–28.

    Article  PubMed  Google Scholar 

  • Nagy R, Sweet K, Eng C. Highly penetrant hereditary cancer syndromes. Oncogene 2004;23:6445–6470.

    Article  CAS  PubMed  Google Scholar 

  • Roach ES, Sparagana SP. Diagnosis of tuberous sclerosis complex. J Child Neurol. 2004;19:643–649.

    PubMed  Google Scholar 

  • Woodward ER, Maher ER. Von Hippel-Lindau disease and endocrine tumour susceptibility. Endocr Relat Cancer 2006;13:415–425.

    Article  CAS  PubMed  Google Scholar 

  • Zbar B, Glenn G, Merino M, et al. Familial renal carcinoma: clinical evaluation, clinical subtypes and risk of renal carcinoma development. J Urol. 2007;177:461–465.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Diagnostic Pathology Services, Inc., Nampa, ID

    Michelle P. Elieff MD (Staff Pathologist)

  2. Department of Pathology and Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran MD, PhD (Professor of Pathology)

  3. Institute of Pathological Anatomy and Histopathology Polytechnic University of the Marche Region (Ancona) School of Medicine, United Hospitals, Ancona, Italy

    Rodolfo Montironi MD, FRCPath (Professor of Pathology)

  4. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN

    Liang Cheng MD (Professor of Pathology and Urology, Director of Molecular Pathology Laboratory, Chief, Genitourinary Pathology Division)

  5. Clarian Pathology Laboratory, Indiana University School of Medicine, Indianapolis, IN

    Liang Cheng MD (Professor of Pathology and Urology, Director of Molecular Pathology Laboratory, Chief, Genitourinary Pathology Division)

Authors
  1. Michelle P. Elieff MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Antonio Lopez-Beltran MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rodolfo Montironi MD, FRCPath
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Liang Cheng MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine and Clarian Pathology Laboratory, Indiana University School of Medicine, Indianapolis, IN

    Liang Cheng MD (Professor of Pathology and Urology, Director of Molecular Pathology Laboratory, Chief of Genitourinary Pathology Division) (Professor of Pathology and Urology, Director of Molecular Pathology Laboratory, Chief of Genitourinary Pathology Division)

  2. Department of Pathology, Mount Sinai School of Medicine, New York, NY

    David Y. Zhang MD, PhD, MPH (Associate Professor of Pathology Director, Molecular Pathology Laboratory) (Associate Professor of Pathology Director, Molecular Pathology Laboratory)

  3. Mount Sinai Medical Center, New York, NY

    David Y. Zhang MD, PhD, MPH (Associate Professor of Pathology Director, Molecular Pathology Laboratory) (Associate Professor of Pathology Director, Molecular Pathology Laboratory)

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Humana Press, a part of Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Elieff, M.P., Lopez-Beltran, A., Montironi, R., Cheng, L. (2008). Familial Cancer Syndromes. In: Cheng, L., Zhang, D.Y. (eds) Molecular Genetic Pathology. Humana Press. https://doi.org/10.1007/978-1-59745-405-6_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-59745-405-6_18

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-974-1

  • Online ISBN: 978-1-59745-405-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation