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Psychodynamic Treatment of Panic Disorder

Clinical and Research Assessment

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Handbook of Evidence-Based Psychodynamic Psychotherapy

Part of the book series: Current Clinical Psychiatry ((CCPSY))

Abstract

Both pharmacological [1–3] and cognitive-behavioral treatments [4–6] of panic disorder have been found to be effective in treatment. Despite this progress, not all patients respond or are able to tolerate these treatments [4–8]. Relapse is frequent if medication is discontinued before a prolonged maintenance phase [9–12]. Questions remain about the long-term effectiveness of these interventions [4, 13]. In studies of “routine care,” generally a poorly defined mix, patients frequently demonstrate persistent symptoms and problems functioning [14]. Little systematic data are available about whether or not these treatments are effective in treating impairments associated with panic disorder, such as occupational dysfunction, relationship difficulties, and diminished quality of life [15, 16]. Given the high morbidity and health costs of this disorder [17–20], it is important to continue to develop the most effective treatments for panic disorder and its related impairments.

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Notes

  1. 1.

    Portions of this chapter are reprinted with permission from Busch FN. Psychodynamic treatment of panic disorder. Prim Psychiatry 2006;13(5):61–66.

    Figs 2.1 and 2.2, and Tables 2.1 and 2.2 are reprinted with permission from the American Journal of Psychiatry (Copyright 2007), American Psychiatric Publishing, Inc. from Milrod B, Busch F, Leon AC, et al.: A randomized controlled clinical trial of psychoanalytic psychotherapy for panic disorder. Am J Psychiatry 2007; 164(2):265–272.

References

  1. Otto MW, Tuby KS, Gould RA, McLean RY, Pollack MH: An effect-size analysis of the relative efficacy and tolerability of serotonin selective reuptake inhibitors for panic disorder. Am J Psychiatry 2001;158(12):1989–1992.

    Article  CAS  PubMed  Google Scholar 

  2. Bakker A, van Balkom AJ, Spinhoven P: SSRIs vs. TCA’s in the treatment of panic disorder: a meta-analysis. Acta Psychiatr Scand 2002; 106(3):163–167.

    Article  CAS  PubMed  Google Scholar 

  3. Wilkinson G, Balestrieri M, Ruggeri M, Bellantuono C: Meta-analysis of double-blind placebo-controlled trials of antidepressants and benzodiazepines for patients with panic disorder. Psychol Med 1991;21(4):991–998.

    Article  CAS  PubMed  Google Scholar 

  4. Barlow DH, Gorman JM, Shear MK et al.: Cognitive-behavioral therapy, imipramine, or their combination for panic disorder. JAMA 2000;283:2529–2536.

    Article  CAS  PubMed  Google Scholar 

  5. Craske MG, Brown TA, Barlow DH: Behavioral treatment of panic: a two-year follow-up. Behav Ther 1991;22:289–304.

    Article  Google Scholar 

  6. Craske MG, DeCola JP, Sachs AD et al.: Panic control treatment for agoraphobia. J Anxiety Disord 2003;17:321–333.

    Article  PubMed  Google Scholar 

  7. Marks IM, Swinson RP, Basoglu M et al.: Alprazolam and exposure alone and combined in panic disorder with agoraphobia. Br J Psychiatry 1993;162:776–787.

    Article  CAS  PubMed  Google Scholar 

  8. Shear MK, Maser JD: Standardized assessment for panic disorder research: a conference report. Arch Gen Psychiatry 1994;51:346–354.

    CAS  PubMed  Google Scholar 

  9. Mavissakalian M, Michelson L: Two year follow-up of exposure and imipramine treatment of agoraphobia. Am J Psychiatry 1986;143:1106–1112.

    CAS  PubMed  Google Scholar 

  10. Nagy LM, Krystal JH, Woods SW et al.: Clinical and medication outcome after short-term alprasolam and behavioral group treatment in panic disorder: 2.5 year naturalistic follow-up study. Arch Gen Psychiatry 1989;46:993–999.

    CAS  PubMed  Google Scholar 

  11. Noyes R Jr, Garvey MJ, Cook BL: Follow-up study of patients with panic disorder and agoraphobia with panic attacks treated with tricyclic antidepressants. J Affect Disord 1989;16:249–257.

    Article  PubMed  Google Scholar 

  12. Pollack MH, Otto MW, Tesar GE et al.: Long-term outcome after acute treatment with alprasolam and clonazepam for panic disorder. J Clin Psychopharmacol 1993;13:257–263.

    Article  CAS  PubMed  Google Scholar 

  13. Milrod B, Busch F: The long-term outcome of treatments for panic disorder: a review of the literature. J Nerv Ment Dis 1996;184:723–730.

    Article  CAS  PubMed  Google Scholar 

  14. Vanelli M: Improving treatment response in panic disorder. Prim Psychiatry 2005;12(11): 68–73.

    Google Scholar 

  15. Markowitz JS, Weissman MM, Ouellette R et al.: Quality of life in panic disorder. Arch Gen Psychiatry 1989;46:984–992.

    CAS  PubMed  Google Scholar 

  16. Rubin, HC, Rapaport, MH, Levine B et al.: Quality of well-being in panic disorder: the assessment of psychiatric and general disability. J Affect Disord 2000;57:217–21.

    Article  CAS  PubMed  Google Scholar 

  17. Katon W: Panic disorder: relationship to high medical utilization, unexplained physical symptoms, and medical costs. J Clin Psychiatry 1996;57(Suppl 10):11–18.

    PubMed  Google Scholar 

  18. Swenson RP, Cox BJ, Woszezy CB: Use of medical services and treatment for panic disorder with agoraphobia and for social phobia. J Can Med Assoc 1992;147:878–883.

    Google Scholar 

  19. Fyer AJ, Liebowitz MR, Gorman JM et al.: Discontinuation of alprazolam in panic patients. Am J Psychiatry 1987;144:303–308.

    CAS  PubMed  Google Scholar 

  20. O’Sullivan G, Marks I: Follow-up studies of behavioral treatment of phobic and obsessive compulsive neurosis. Psychiatr Ann 1991;21:368–373.

    Google Scholar 

  21. Busch FN, Cooper AM, Klerman GL, Shapiro T, Shear MK: Neurophysiological, cognitive-behavioral and psychoanalytic approaches to panic disorder: toward an integration. Psychoanal Inq 1991;11:316–332.

    Article  Google Scholar 

  22. Shear MK, Cooper AM, Klerman GL, Busch FN, Shapiro T: A psychodynamic model of panic disorder. Am J Psychiatry 1993;150:859–866.

    CAS  PubMed  Google Scholar 

  23. Milrod BL, Busch FN, Cooper AM, Shapiro T: Manual of Panic-focused Psychodynamic Psychotherapy. Washington, DC, American Psychiatric Press, 1997.

    Google Scholar 

  24. Breuer J, Freud S: Studies on hysteria (1895), in The Standard Edition of the Complete Psychological Works of Sigmund Freud, vol. 2, translated and edited by Strachey J. London, Hogarth Press, 1959, pp 1–183.

    Google Scholar 

  25. Kleiner L, Marshall WL: The role of interpersonal problems in the development of agoraphobia with panic attacks. J Anxiety Disord 1987;1:313–323.

    Article  Google Scholar 

  26. Freud S: The neuropsychoses of defence (1894), in The Standard Edition of the Complete Psychologic Works of Sigmund Freud, vol. 3, translated and edited by Strachey J. London, Hogarth Press, 1959, pp 45–61.

    Google Scholar 

  27. Busch FN, Shear MK, Cooper AM, Shapiro T, Leon A: An empirical study of defense mechanisms in panic disorder. J Nerv Ment Dis 1995;183:299–303.

    Article  CAS  PubMed  Google Scholar 

  28. Busch FN, Milrod BL, Singer MB: Theory and technique in the psychodynamic treatment of panic disorder. J Psychother Pract Res 1999;8:234–242.

    CAS  PubMed  Google Scholar 

  29. Parker G: Reported parental characteristics of agoraphobics and social phobics. Br J Psychiatry 1979;135:555–560.

    Article  CAS  PubMed  Google Scholar 

  30. Arrindell W, Emmelkamp PMG, Monsma A et al.: The role of perceived parental rearing practices in the etiology of phobic disorders: a controlled study. Br J Psychiatry 1983;143:183–187.

    Article  CAS  PubMed  Google Scholar 

  31. Freud S: Inhibitions, symptoms and anxiety (1926), in The Standard Edition of the Complete Psychological Works of Sigmund Freud, vol. 20, translated and edited by Strachey J. London, Hogarth Press, 1959, pp 77–174.

    Google Scholar 

  32. Kagan J, Reznick JS, Snidman N et al.: Origins of panic disorder, in Neurobiology of Panic Disorder, Ballenger J. (ed.) New York, Wiley, 1990, pp 71–87.

    Google Scholar 

  33. Gorman JM., Kent JM, Sullivan G M, Coplan JD: Neuroanatomical hypothesis of panic disorder, revised. Am J Psychiatry 2000;157:493–505.

    Article  CAS  PubMed  Google Scholar 

  34. Busch FN, Milrod BL: The nature and treatment of panic disorder, in Textbook of Biological Psychiatry, Panksepp, J. (ed.). Hoboken, NJ, Wiley, 2003, pp. 367–392.

    Google Scholar 

  35. Panksepp J: Affective Neuroscience. New York, Oxford, 1998.

    Google Scholar 

  36. Neumeister A, Bain E, Nugent AC, Carson RE, Bonne O, Luckenbaugh DA, Eckelman W, Herscovitch P, Charney DS, Drevets WC: Reduced serotonin type 1A receptor binding in panic disorder. J Neurosci 2004;24(3):589–591.

    Article  CAS  PubMed  Google Scholar 

  37. Hogg S, Michan L, Jessa M: Prediction of anti-panic properties of escitalopram in the dorsal periaqueductal grey model of panic anxiety. Neuropharmacology 2006;51:141–145.

    Article  CAS  PubMed  Google Scholar 

  38. El-Khodor BF, Dimmler MH, Amara DA, Hofer M, Hen R, Brunner D: Juvenile 5HT(1B) receptor knockout mice exhibit reduced pharmacological sensitivity to 5HT(1A) receptor activation. Int J Dev Neurosci 2004;22(5–6):405–413.

    Article  CAS  PubMed  Google Scholar 

  39. Rauch SL, Shin LM, Wright CI: Neuroimaging studies of amygdala function in anxiety disorders. Ann NY Acad Sci 2003;985:389–410.

    Article  PubMed  Google Scholar 

  40. Fonagy P: Thinking about thinking: Some clinical and theoretical considerations in the treatment of a borderline patient. Int J Psychoanal 1991;72:1–18.

    Google Scholar 

  41. Rudden MG, Milrod B, Aronson A, Target M: Reflective functioning in panic disorder patients: clinical observations and research design. In Mentalization: Theoretical Considerations, Research Findings, and Clinical Implications. New York, The Analytic Press: Taylor & Francis Group 2008, pp.185–206.

    Google Scholar 

  42. Milrod B, Busch F, Leon AC et al.: A randomized controlled clinical trial of psychoanalytic psychotherapy for panic disorder. Am J Psychiatry 2007;164(2):265–272.

    Article  PubMed  Google Scholar 

  43. Busch FN, Milrod BL, Singer M: Theory and technique in psychodynamic treatment of panic disorder. J Psychother Pract Res 1999;8:234–242.

    CAS  PubMed  Google Scholar 

  44. Milrod B, Busch F, Leon AC et al.: A pilot open trial of brief psychodynamic psychotherapy for panic disorder. J Psychother Pract Res 2001;10:1–7.

    Google Scholar 

  45. Milrod B, Busch F, Leon A et al.: An open trial of psychodynamic psychotherapy for panic disorder – a pilot study. Am J Psychiatry 2000;157:1878–1880.

    Article  CAS  PubMed  Google Scholar 

  46. Wiborg IM, Dahl AA: Does brief dynamic psychotherapy reduce the relapse rate of panic disorder? Arch Gen Psychiatry 1996;53:689–694.

    CAS  PubMed  Google Scholar 

  47. Barlow DH, Gorman JM, Shear MK Woods SW: Cognitive-behavioral therapy, imipramine, or their combination for panic disorder. JAMA 2000;283:2529–2536.

    Article  CAS  PubMed  Google Scholar 

  48. Cerny, JA, Vermilyea, BB, Barlow, DH et al.: Anxiety treatment project relaxation treatment manual. 1984. Available from the authors

    Google Scholar 

  49. Craske MG, Brown TA, Barlow DH: Behavioral treatment of panic disorder: a two-year follow-up. Behav Ther 1991;22:289–304.

    Article  Google Scholar 

  50. Shear MK, Brown TA, Barlow DH et al.: Multicenter collaborative Panic Disorder Severity Scale. Am J Psychiatry 1997;154:1571–1575.

    CAS  PubMed  Google Scholar 

  51. Sheehan DV: The Sheehan disability scales. in The Anxiety Disease. New York, Charles Scribner and Sons 1983, p. 151.

    Google Scholar 

  52. Hamilton M: A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56–62.

    Article  CAS  PubMed  Google Scholar 

  53. Hamilton M: The assessment of anxiety states by rating. Br J Med Psychol 1959;32:50–55.

    CAS  PubMed  Google Scholar 

  54. Otto MW, Pollack MH: Adherence ratings for ART. Available from the authors.

    Google Scholar 

  55. Marks IM, Swinson RP, Basoglu M, Kuch K, Noshirvani H, O’Sullivan G, Lelliott PT, Kirby M, McNamee G, Sengun S, Wickwire K: Alprazolam and exposure alone and combined in panic disorder with agoraphobia: a controlled study in London and Toronto. Br J Psychol 1993;162:776–787.

    Article  CAS  Google Scholar 

  56. Clark DM, Salkovskis PM, Hackman A, Middleton H, Anastasiades P, Gelder M: A comparison of cognitive therapy, applied relaxation, and imipramine in the treatment of panic disorder. Br J Psychiatry 1994;164:759–769.

    Article  CAS  PubMed  Google Scholar 

  57. Fava GA, Zielezny M, Savron G, Grandi S: Long-term effects of behavioral treatment for panic disorder with agoraphobia. Br J Psychiatry 1995;166:87–92.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Frederic N. Busch MD .

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Busch, F.N., Milrod, B. (2009). Psychodynamic Treatment of Panic Disorder. In: Levy, R.A., Ablon, J.S. (eds) Handbook of Evidence-Based Psychodynamic Psychotherapy. Current Clinical Psychiatry. Humana Press. https://doi.org/10.1007/978-1-59745-444-5_2

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  • DOI: https://doi.org/10.1007/978-1-59745-444-5_2

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