Abstract
Infections remain a significant issue in the care of immunocompromised patients, including those with malignancies, HIV infection, rheumatologic disorders, or those who undergo solid organ or stem cell transplantation. Risk factors for infection in these patients include not only neutropenia but also immune deficiencies inherent to the primary disease process, such as those seen in patients with a variety of hematologic disorders, as well as HIV infection. In addition, therapeutic agents used for these disorders, such as the purine analogs or tumor necrosis factor-α inhibitors, may also result in immune disregulation. A characteristic spectrum of infectious complications may be seen in each of these disorders, as well as in association with specific therapeutic modalities. In this chapter, the predisposing factors for infection, delineation of specific infections, and approaches to the prophylaxis and therapy of these complications are presented for immunocompromised patients including those with cancer, HIV infection, neutropenia, recipients of stem cell or solid organ transplants, and individuals receiving tumor necrosis factor-α inhibitor therapy.
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Baker, C., Morrison, V.A. (2010). Infections in the Immunocompromised Host. In: Mainous III, A., Pomeroy, C. (eds) Management of Antimicrobials in Infectious Diseases. Infectious Disease. Humana Press. https://doi.org/10.1007/978-1-60327-239-1_19
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DOI: https://doi.org/10.1007/978-1-60327-239-1_19
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