Skip to main content

Gestational Diabetes Mellitus: Diagnosis, Maternal and Fetal Outcomes, and Management

  • Chapter
  • First Online:
Diabetes in Women

Part of the book series: Contemporary Diabetes ((CDI))

  • 1292 Accesses

Abstract

Gestational diabetes mellitus (GDM), or diabetes first recognized during pregnancy, is associated with increased risk of adverse perinatal outcomes. After GDM delivery, both mothers and offspring are at risk for long-term chronic disease. Clinical recognition and treatment of GDM may reduce peripartum risk, but there is a lack of consensus on how to define, screen and treat GDM. There is also a lack of information on how treatment affects long-term outcomes as well as precise information on the prevalence of long-term outcomes. Consensus regarding the definition of GDM may be achieved in the next several years with completion of the HAPO trial, but further study on the long-term effects of oral medications other than insulin is needed, and greater attention needs to be devoted to improving postpartum screening and to the follow-up and intervention for women and offspring to improve long-term outcomes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Kjos S, Buchanan T. Gestational diabetes mellitus. N Engl J Med 1999;341(23):1749–56.

    CAS  PubMed  Google Scholar 

  2. Jovanovic L, Pettitt D. Gestational diabetes mellitus. JAMA 2001;286(20):2516–9.

    CAS  PubMed  Google Scholar 

  3. Dodd J, Crowther C, Antoniou G, Baghurst P, Robinson J. Screening for gestational diabetes: the effect of varying blood glucose definitions in the prediction of adverse maternal and infant health outcomes. Aust N Z J Obstet Gynaecol 2007;47(4):307–12.

    PubMed  Google Scholar 

  4. Saydah S, Chandra A, Eberhardt M. Pregnancy experience among women with and without gestational diabetes in the U.S. 1995 National Survey of Family Growth. Diabetes Care 2005;28:1035–40.

    PubMed  Google Scholar 

  5. HAPO Study Cooperative Research Group. The hyperglycemia and adverse pregnancy outcome (HAPO) study. Int J Gynaecol Obstet 2002;78(1):69–77.

    Google Scholar 

  6. Dabelea D. The predisposition to obesity and diabetes in offspring of diabetic mothers. Diabetes Care 2007;30(Suppl 2):S169–74.

    PubMed  Google Scholar 

  7. Dabelea D, Hanson R, Lindsay R, et al. Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes 2000;49(12):2208–11.

    CAS  PubMed  Google Scholar 

  8. Carr D, Utzschneider K, Hull R, et al. Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes. Diabetes Care 2006;29:2078–83.

    PubMed  Google Scholar 

  9. Shah B, Retnakaran R, Booth G. Increased risk of cardiovascular disease in young women following gestational diabetes. Diabetes Care 2008;31(8):1668–9.

    PubMed  Google Scholar 

  10. Crowther C, Hiller J, Moss J, et al. Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med 2005;352:2477–86.’

    CAS  PubMed  Google Scholar 

  11. O’Sullivan J, Mahan C. Criteria for the oral glucose tolerance test in pregnancy. Diabetes 1964;13:278–85.

    PubMed  Google Scholar 

  12. National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 1979;18:1039–57.

    Google Scholar 

  13. Carpenter M, Coustan D. Criteria for screening tests for gestational diabetes. Am J Obstet Gynecol 1982;144(7):768–73.

    CAS  PubMed  Google Scholar 

  14. Sacks D, Abu-Fadil S, Greenspoon J, Fotheringham N. Do the current standards for glucose tolerance testing in pregnancy represent a valid conversion of O’Sullivan’s original criteria? Am J Obstet Gynecol 1989;161(3):638–41.

    CAS  PubMed  Google Scholar 

  15. Metzger B, Coustan D. Summary and recommendations of the Fourth International Workshop-Conference on Gestational Diabetes Mellitus: the Organizing Committee. Diabetes Care 1998;21:B161–7.

    PubMed  Google Scholar 

  16. American Diabetes Association. Clinical practice recommendations 2000. Gestational diabetes mellitus. Diabetes Care 2000;23:S77–9.

    Google Scholar 

  17. Magee M, Walden C, Benedetti T, Knopp R. Influence of diagnostic criteria on the incidence of gestational diabetes and perinatal morbidity. JAMA 1993;269(5):609–15.

    CAS  PubMed  Google Scholar 

  18. Ricart W, Lopez J, Mozas J, et al. Potential impact of the American Diabetes Association (2000) criteria for the diagnosis of gestational diabetes mellitus in Spain. Diabetologia 2005;48(6):1135–41.

    CAS  PubMed  Google Scholar 

  19. Sermer M, Naylor C, Gare D, et al. Impact of increasing carbohydrate intolerance on maternal-fetal outcomes in 3637 women without gestational diabetes. The Toronto Tri-Hospital Gestational Diabetes Project. Am J Obstet Gynecol 1995;173(1):146–56.

    CAS  PubMed  Google Scholar 

  20. Ferrara A, Weiss N, Hedderson M, et al. Pregnancy plasma glucose levels exceeding the American Diabetes Association thresholds, but below the National Diabetes Data Group thresholds for gestational diabetes mellitus, are related to the risk of neonatal macrosomia, hypoglycaemia, and hyperbilirubinaemia. Diabetologia 2007;50(2):298–306.

    CAS  PubMed  Google Scholar 

  21. World Health Organization. Definition, diagnosis, and classification of diabetes mellitus and its complications: report of a WHO consultation, Part 1: Diagnosis and classification of diabetes mellitus. Geneva: World Health Organization; 1999.

    Google Scholar 

  22. World Health Organization. World Health Expert Committee on diabetes mellitus: second report. Geneva: World Health Organization; 1980.

    Google Scholar 

  23. Schmidt M, Duncan B, Reichelt A, et al. Gestational diabetes mellitus diagnosed with a 2-h 75-g oral glucose tolerance test and adverse pregnancy outcomes. Diabetes Care 2001;24(7):1151–5.

    CAS  PubMed  Google Scholar 

  24. Pettitt D. The 75-g oral glucose tolerance test in pregnancy. Diabetes Care 2001;24(7):1129.

    CAS  PubMed  Google Scholar 

  25. ACOG Practice Bulletin. Clinical management guidelines for obstetrician-gynecologists. Number 30, September 2001 (replaces Technical Bulletin Number 200, December 1994). Obstet Gynecol 2001;98(3):525–38.

    Google Scholar 

  26. American Diabetes Association. Gestational diabetes mellitus. Diabetes Care 2004;27(Suppl 1):S88–90.

    Google Scholar 

  27. Danilenko-Dixon D, Van Winter J, Nelson R, Ogburn P. Jr. Universal versus selective gestational diabetes screening: application of 1997 American Diabetes Association recommendations. Am J Obstet Gynecol 1999;181(4):798–802.

    CAS  PubMed  Google Scholar 

  28. Naylor C, Sermer M, Chen E, Farine D. Selective screening for gestational diabetes mellitus: Toronto Trihospital Gestational Diabetes Project Investigators. N Engl J Med 1997;337(22):1591–6.

    CAS  PubMed  Google Scholar 

  29. Carr S. Screening for gestational diabetes mellitus. A perspective in 1998. Diabetes Care 1998;21(Suppl 2):B14–8.

    PubMed  Google Scholar 

  30. Coustan D, Widness J, Carpenter M, Rotondo L, Pratt D, Oh W. Should the fifty-gram, one-hour plasma glucose screening test for gestational diabetes be administered in the fasting or fed state? Am J Obstet Gynecol 1986;154(5):1031–5.

    CAS  PubMed  Google Scholar 

  31. Watson W. Serial changes in the 50-g oral glucose test in pregnancy: implications for screening. Obstet Gynecol 1989;74(1):40–3.

    CAS  PubMed  Google Scholar 

  32. Nahum G, Huffaker B. Correlation between first- and early third-trimester glucose screening test results. Obstet Gynecol 1990;76(4):709–13.

    CAS  PubMed  Google Scholar 

  33. McElduff A, Hitchman R. Screening for gestational diabetes: the time of day is important. Med J Aust 2002;176(3):136.

    PubMed  Google Scholar 

  34. Aparicio N, Joao M, Cortelezzi M, et al. Pregnant women with impaired glucose tolerance to an oral glucose load in the afternoon. Am J Obstet Gynecol 1998;178(5):1059–66.

    CAS  PubMed  Google Scholar 

  35. Sermer M, Naylor C, Gare D, et al. Impact of time since last meal on the gestational glucose challenge test. The Toronto Tri-Hospital Gestational Diabetes Project. Am J Obstet Gynecol 1994;171(3):607–16.

    CAS  PubMed  Google Scholar 

  36. Berkus M, Stern M, Mitchell B, Abashawl A, Langer O. Relationships between glucose levels and insulin secretion during a glucose challenge test. Am J Obstet Gynecol 1990;163(6 Pt 1):1818–22.

    CAS  PubMed  Google Scholar 

  37. Lewis G, McNally C, Blackman J, Polonsky K, Barron W. Prior feeding alters the response to the 50-g glucose challenge test in pregnancy. The Staub-Traugott effect revisited. Diabetes Care 1993;16(12):1551–6.

    CAS  PubMed  Google Scholar 

  38. HAPO Study Cooperative Research Group. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 2008;358(19):1991–2002.

    Google Scholar 

  39. Reader D. Medical nutrition therapy and lifestyle interventions. Diabetes Care 2007;30(Suppl 2):S188–93.

    CAS  PubMed  Google Scholar 

  40. Jovanovic-Peterson L, Peterson C. Nutritional management of the obese gestational diabetic pregnant woman. J Am Coll Nutr 1992;3:246–50.

    Google Scholar 

  41. Walkinshaw S. Dietary regulation for gestational diabetes. Cochrane Database Syst Rev 2000;(4)CD000070.

    Google Scholar 

  42. Food and Nutrition Board. Nutrition during pregnancy, Part 1: weight gain, Part 2: nutrition supplements. Washington, DC: Institute of Medicine, National Academy of Sciences; 1990.

    Google Scholar 

  43. Hedderson M, Weiss N, Sacks D, et al. Pregnancy weight gain and risk of neonatal complications: macrosomia, hypoglycemia, and hyperbilirubinemia. Obstet Gynecol 2006;108(5):1153–61.

    PubMed  Google Scholar 

  44. Horton E. Exercise in the treatment of NIDDK. Applications for GDM? Diabetes 1991;40(Suppl 2):175–8.

    PubMed  Google Scholar 

  45. Jovanovic-Peterson L, Durak E, Peterson C. Randomized trial of diet versus diet plus cardiovascular conditioning on glucose levels in gestational diabetes. Am J Obstet Gynecol 1989;161:415–9.

    CAS  PubMed  Google Scholar 

  46. Bung P, Artal R, Khodiguian N, Kjos S. Exercise in gestational diabetes. An optional therapeutic approach? Diabetes 1991;40(Suppl 2):182–5.

    PubMed  Google Scholar 

  47. Laird J, McFarland K. Fasting blood glucose levels and initiation of insulin therapy in gestational diabetes. Endocr Pract 1996;2:330–2.

    CAS  PubMed  Google Scholar 

  48. de Veciana M, Major C, Morgan M, et al. Postprandial versus preprandial blood glucose monitoring in women with gestational diabetes mellitus requiring insulin therapy. N Engl J Med 1995;333(19):1237–41.

    PubMed  Google Scholar 

  49. Jovanovic-Peterson L, Peterson C, Reed G, et al. Maternal postprandial glucose levels and infant birth weight: the Diabetes in Early Pregnancy Study. The National Institute of Child Health and Human Development - Diabetes in Early Pregnancy Study. Am J Obstet Gynecol 1991;164(1 Pt 1):103–11.

    CAS  PubMed  Google Scholar 

  50. Nachum Z, Ben-Shlomo I, Weiner E, Shalev E. Twice daily vs. four times daily insulin dose regimens for diabetes in pregnancy: randomised controlled trial. BMJ 1999;319:1223–7.

    CAS  PubMed  Google Scholar 

  51. Kjos S, Schaefer-Graf U, Sardesi S, et al. A randomized controlled trial using glycemic plus fetal ultrasound parameters versus glycemic parameters to determine insulin therapy in gestational diabetes with fasting hyperglycemia. Diabetes Care 2001;24(11):1904–10.

    CAS  PubMed  Google Scholar 

  52. Langer O, Conway D, Berkus M, Xenakis E, Gonzales O. A comparison of glyburide and insulin in women with gestational diabetes mellitus. N Engl J Med 2000;343(16):1134–8.

    CAS  PubMed  Google Scholar 

  53. Moore T. Glyburide for the treatment of gestational diabetes: a critical appraisal. Diabetes Care 2007;30:S209–13.

    CAS  PubMed  Google Scholar 

  54. Rowan J, Hague W, Gao W, Battin M, Moore M, MiG Trial Investigators. Metformin versus insulin for the treatment of gestational diabetes. N Engl J Med 2008;358(19):2003–15.

    CAS  PubMed  Google Scholar 

  55. Gilbert C, Valois M, Koren G. Pregnancy outcome after first-trimester exposure to metformin; a meta-analysis. Fertil Steril 2006;86:658–63.

    CAS  PubMed  Google Scholar 

  56. Glueck C, Pranikoff J, Aregawi D, Wang P. Prevention of gestational diabetes by metformin plus diet in patients with polycystic ovary syndrome. Fertil Steril 2008;89:625–34.

    CAS  PubMed  Google Scholar 

  57. Catalano P, Thomas A, Huston-Presley L, Amini S. Increased fetal adiposity: a very sensitive marker of abnormal in-utero development. Am J Obstet Gynecol 2003;189:1698–704.

    PubMed  Google Scholar 

  58. Heikes K, Eddy D, Arondekar B, Schlessinger L. Diabetes Risk Calculator: a simple tool for detecting undiagnosed diabetes and pre-diabetes. Diabetes Care 2008;31(5):1040–5.

    PubMed  Google Scholar 

  59. Gunderson E, Lewis C, Tsai A, et al. A 20-year prospective study of childbearing and incidence of diabetes in young women, controlling for glycemia before conception: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Diabetes 2007;56(12):2990–6.

    CAS  PubMed  Google Scholar 

  60. Cheung N, Byth K. Population health significance of gestational diabetes. Diabetes Care 2003;26:2005–9.

    PubMed  Google Scholar 

  61. Heitritter S, Solomon C, Mitchell G, Skali-Ounis N, Seely E. Subclinical inflammation and vascular dysfunction in women with previous gestational diabetes mellitus. J Clin Endocrinol Metab 2005;90:3983–88.

    CAS  PubMed  Google Scholar 

  62. Metzger B, Buchanan T, Coustan D, et al. Summary and recommendations of the Fifth International Workshop-Conference on Gestational Diabetes Mellitus. Diabetes Care 2007;30(2):S251–60.

    CAS  PubMed  Google Scholar 

  63. Canadian Diabetes Association. Gestational diabetes mellitus.Clinical Practice Guidelines Expert Committee. 2003 Practice Guidelines. Toronto, ON: Canadian Diabetes Association; 2003 (accessed August 1, 2008, at http://www.diabetes.ca/cpg2003/downloads/gdm.pdf).

  64. National Institute for Health and Clinical Excellence (NICE). Diabetes in pregnancy: management of diabetes and its complications from preconception to the postnatal period. London: National Collaborating Centre for Women’s and Children’s Health; 2008.

    Google Scholar 

  65. World Health Organization. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: a report of WHO/IDF consultation. Geneva: World Health Organization; 2006.

    Google Scholar 

  66. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2008;31(Suppl1):S55–60.

    Google Scholar 

  67. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 2003;26:3160–7.

    Google Scholar 

  68. United States Preventive Services Task Force. Screening for gestational diabetes mellitus: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2008;148(10):759–65.

    Google Scholar 

  69. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 1997;20:1183–97.

    Google Scholar 

  70. Harris M, Eastman R, Cowie C, Flegal K, Eberhardt M. Comparison of diabetes diagnostic categories in the U.S. population according to 1997 American Diabetes Association and 1980–1985 World Health Organization diagnostic criteria. Diabetes Care 1997;20:1859–62.

    CAS  PubMed  Google Scholar 

  71. DECODE Study Group. Will new diagnostic criteria for diabetes mellitus change phenotype of patients with diabetes? BMJ 1998;317:371–5.

    Google Scholar 

  72. Pallardo F, Herranz L, Garcia-Ingelmo T, et al. Early postpartum metabolic assessment in women with prior gestational diabetes. Diabetes Care 1999;22:1053–8.

    CAS  PubMed  Google Scholar 

  73. Kitzmiller J, Dang-Kilduff L, Taslimi M. Gestational diabetes after delivery: short-term management and long-term risks. Diabetes Care 2007;30(Suppl2):S225–35.

    CAS  PubMed  Google Scholar 

  74. Hunt K, Conway D. Who returns for postpartum glucose screening following gestational diabetes mellitus? Am J Obstet Gynecol 2008;198(4):404.e1–6.

    PubMed  Google Scholar 

  75. Ferrara A, Peng T, Kim C. Trends in postpartum diabetes screening and subsequent diabetes and impaired fasting glucose among women with histories of gestational diabetes mellitus: a report from the Translating Research Into Action for Diabetes (TRIAD) Study. Diabetes Care 2009;32:269–74.

    PubMed  Google Scholar 

  76. Reinblatt S, Morin L, Meltzer S. The importance of a postpartum 75 gram oral glucose tolerance test in women with gestational diabetes. J Obstet Gynaecol Can 2006;28(8):690–4.

    PubMed  Google Scholar 

  77. Agarwal M, Punnose J, Dhatt G. Gestational diabetes: implications of variation in post-partum follow-up criteria. Eur J Obstet Gynecol Reprod Biol 2004;113(2):149–53.

    PubMed  Google Scholar 

  78. Kim C, Herman W, Vijan S. Efficacy and cost of postpartum screening strategies for diabetes among women with histories of gestational diabetes mellitus. Diabetes Care 2007;30:1102–6.

    PubMed  Google Scholar 

  79. Smirnakis K, Chasan-Taber L, Wolf M, Markenson G, Ecker J, Thadhani R. Postpartum diabetes screening in women with a history of gestational diabetes. Obstet Gynecol 2005;106(6):1297–303.

    PubMed  Google Scholar 

  80. Russell M, Phipps M, Olson C, Welch H, Carpenter M. Rates of postpartum glucose testing after gestational diabetes mellitus. Obstet Gynecol 2006;108(6):1456–62.

    PubMed  Google Scholar 

  81. Kim C, Tabaei B, Burke R, et al. Missed opportunities for diabetes screening among women with a history of gestational diabetes. Am J Public Health 2006;96:1–9.

    Google Scholar 

  82. Clark H, van Walraven C, Code C, Karovitch A, Keely E. Did publication of a clinical practice guideline recommendation to screen for type 2 diabetes in women with gestational diabetes change practice? Diabetes Care 2003;26:265–8.

    PubMed  Google Scholar 

  83. Kim C, McEwen L, Piette J, Goewey J, Ferrara A, Walker E. Risk perception for diabetes among women with histories of gestational diabetes mellitus. Diabetes Care 2007;30(9):2281–6.

    PubMed  Google Scholar 

  84. Gabbe S, Gregory R, Power M, Williams S, Schulkin J. Management of diabetes mellitus by obstetrician-gynecologists. Obstet Gynecol 2004;103(6):1229–34.

    PubMed  Google Scholar 

  85. Gabbe S, Hill L, Schmidt L, Schulkin J. Management of diabetes by obstetrician-gynecologists. Obstet Gynecol 1998;91(5 Pt 1):643–7.

    CAS  PubMed  Google Scholar 

  86. Kim C, McEwen L, Kerr E, et al. Preventive counseling among women with histories of gestational diabetes mellitus. Diabetes Care 2007;30(10):2489–95.

    PubMed  Google Scholar 

  87. Nicholson W, Wilson L, Witkop C, et al. Therapeutic management, delivery, and postpartum risk assessment and screening in gestational diabetes. Evid Rep Technol Assess (Full Rep) 2008;162:1–96.

    Google Scholar 

  88. Retnakaran R, Qi Y, Sermer M, Connelly P, Zinman B, Hanley A. Isolated hyperglycemia at 1-hour on oral glucose tolerance test in pregnancy resembles gestational diabetes in predicting postpartum metabolic dysfunction. Diabetes Care 2008;31(7):1275–81.

    CAS  PubMed  Google Scholar 

  89. Cheung N, Helmink D. Gestational diabetes: the significant of persistent fasting hyperglycemia for the subsequent development of diabetes mellitus. J Diabetes Complications 2006;20(1):21–5.

    PubMed  Google Scholar 

  90. Steinhart J, Sugarman J, Connell F. Gestational diabetes is a herald of NIDDM in Navajo women. Diabetes Care 1997;20(6):943–7.

    CAS  PubMed  Google Scholar 

  91. Cho N, Lim S, Jang H, Park H, Metzger B. Elevated homocysteine as a risk factor for the development of diabetes in women with a previous history of gestational diabetes mellitus: a 4-year prospective study. Diabetes Care 2005;28(11):2750–5.

    CAS  PubMed  Google Scholar 

  92. Kjos S, Peters R, Xiang A, Henry O, Montoro M, Buchanan T. Predicting future diabetes in Latino women with gestational diabetes. Diabetes 1995;44:586–91.

    CAS  PubMed  Google Scholar 

  93. Schaefer-Graf U, Buchanan T, Xiang A, Peters R, Kjos S. Clinical predictors for a high risk for the development of diabetes mellitus in the early puerperium in women with recent gestational diabetes mellitus. Am J Obstet Gynecol 2002;186:751–6.

    PubMed  Google Scholar 

  94. Catalano P, Vargo K, Bernstein I, Amini S. Incidence and risk factors associated with abnormal postpartum glucose tolerance in women with gestational diabetes. Am J Obstet Gynecol 1991;165(4 Pt 1):914–9.

    CAS  PubMed  Google Scholar 

  95. Buchanan T, Xiang A, Kjos S, Trigo E, Lee W, Peters R. Antepartum predictors of the development of type 2 diabetes in Latino women 11–26 months after pregnancies complicated by gestational diabetes. Diabetes 1999;48:2430–6.

    CAS  PubMed  Google Scholar 

  96. Jang H, Yim C, Han K, et al. Gestational diabetes mellitus in Korea: prevalence and prediction of glucose intolerance at early postpartum. Diabetes Res Clin Pract 2003;61(2):117–24.

    CAS  PubMed  Google Scholar 

  97. Metzger B, Cho N, Roston S, Radvany R. Prepregnancy weight and antepartum insulin secretion predict glucose tolerance five years after gestational diabetes mellitus. Diabetes Care 1993;16:1598–605.

    CAS  PubMed  Google Scholar 

  98. Peters R, Kjos S, Xiang A, Buchanan T. Long-term diabetogenic effect of a single pregnancy in women with prior gestational diabetes mellitus. Lancet 1996;347:227–30.

    CAS  PubMed  Google Scholar 

  99. Buchanan T, et al. Gestational diabetes: antepartum characteristics that predict postpartum glucose intolerance and type 2 diabetes in Latino women. Diabetes 1998;47(8):1302–10.

    CAS  PubMed  Google Scholar 

  100. Lobner K, Knopff A, Baumgarten A, et al. Predictors of postpartum diabetes in women with gestational diabetes mellitus. Diabetes 2006;55(3):792–7.

    PubMed  Google Scholar 

  101. Greenberg L, Moore T, Murphy H. Gestational diabetes mellitus: antenatal variables as predictors of postpartum glucose intolerance. Obstet Gynecol 1995;86(1):97–101.

    CAS  PubMed  Google Scholar 

  102. Dalfra M, Lapolla A, Masin M. Antepartum and early postpartum predictors of type 2 diabetes development in women with gestational diabetes mellitus. Diabetes Metab 2001;27(6):675–80.

    CAS  PubMed  Google Scholar 

  103. Henry O, Beischer N. Long-term implications of gestational diabetes for the mother. Baillieres Clin Obstet Gynaecol 1991; 5(2):461–83.

    CAS  PubMed  Google Scholar 

  104. Catalano P, Vargo K, Bernstein I, Amini S. Incidence and risk factors associated with abnormal postpartum glucose tolerance in women with gestational diabetes. Am J Obstet Gynecol 1991;163:93–8.

    Google Scholar 

  105. Bartha J, Martinez-del-Fresno P, Comino-Delgado R. Postpartum metabolism and autoantibody markers in women with gestational diabetes mellitus diagnosed in early pregnancy. Am J Obstet Gynecol 2001;184(5):965–70.

    CAS  PubMed  Google Scholar 

  106. Persson B, Hanson U, Hartling S, Binder C. Follow-up of women with previous GDM: insulin, C-peptide, and proinsulin responses to oral glucose load. Diabetes 1991;40(Suppl2):136–41.

    PubMed  Google Scholar 

  107. Dacus J, Meyer N, Muram D, Stilson R, Phipps P, Sibai B. Gestational diabetes: postpartum glucose tolerance testing. Am J Obstet Gynecol 1994;171(4):927–31.

    CAS  PubMed  Google Scholar 

  108. Shuldiner A, Yang R, Gong D. Resistin, obesity, and insulin resistance - the emerging role of the adipocyte as an endocrine organ. N Engl J Med 2001;345(18):1345–6.

    CAS  PubMed  Google Scholar 

  109. Branchtein L, Schmidt M, Mengue S, Reichelt A, Matos M, Duncan B. Waist circumference and waist-to-hip ratio are related to gestational glucose tolerance. Diabetes Care 1997;20(4):509–11.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Humana Press, a part of Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Ferrara, A., Kim, C. (2009). Gestational Diabetes Mellitus: Diagnosis, Maternal and Fetal Outcomes, and Management. In: Tsatsoulis, A., Wyckoff, J., Brown, F. (eds) Diabetes in Women. Contemporary Diabetes. Humana Press. https://doi.org/10.1007/978-1-60327-250-6_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-60327-250-6_13

  • Published:

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-249-0

  • Online ISBN: 978-1-60327-250-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics