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Neuroendocrine Tumors of Female Genital Tract

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Surgical Pathology of Endocrine and Neuroendocrine Tumors

Part of the book series: Current Clinical Pathology ((CCPATH))

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Abstract

Neuroendocrine tumors are relatively rare in the female genital tract, and therefore may present a diagnostic challenge. It is important to recognize these tumors as their management and prognosis may differ from the more common tumors with which these may be confused.

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References

  1. Young RH, Oliva E, Scully RE. Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases. Am J Surg Pathol. 1994 Nov;18(11):1102–16.

    Article  PubMed  CAS  Google Scholar 

  2. McCluggage WG. Ovarian neoplasms composed of small round cells: a review. Adv Anat Pathol. 2004 Nov;11(6):288–96. Review.

    Article  PubMed  Google Scholar 

  3. Dickersin GR, Kline IW, Scully RE. Small cell carcinoma of the ovary with hypercalcemia: a report of eleven cases. Cancer. 1982 Jan 1;49(1):188–97.

    Article  PubMed  CAS  Google Scholar 

  4. Clement PB. Selected miscellaneous ovarian lesions: small cell carcinomas, mesothelial lesions, mesenchymal and mixed neoplasms, and non-neoplastic lesions. Mod Pathol. 2005 Feb;18 Suppl 2:S113–29. Review.

    Article  PubMed  Google Scholar 

  5. Schleef J, Wagner A, Kleta R, Schaarschmidt K, Dockhorn-Dworniczak B, Willital G, Jürgens H. Small-cell carcinoma of the ovary of the hypercalcemic type in an 8-year-old girl. Pediatr Surg Int. 1999 Jul;15(5–6):431–4.

    Article  PubMed  CAS  Google Scholar 

  6. Lamovec J, Bracko M, Cerar O. Familial occurrence of small-cell carcinoma of the ovary. Arch Pathol Lab Med. 1995 Jun;119(6):523–7.

    PubMed  CAS  Google Scholar 

  7. Clement PB, Young RH, Scully RE. Clinical syndromes associated with tumors of the female genital tract. Semin Diagn Pathol. 1991 Nov;8(4):204–33. Review.

    PubMed  CAS  Google Scholar 

  8. Popiolek DA, Kumar AR, Mittal K. Large cell variant of small cell carcinoma, hypercalcemic type, of primary peritoneal origin. Gynecol Oncol. 2005 Jan;96(1):249–53.

    Article  PubMed  Google Scholar 

  9. Di Vagno G, Melilli GA, Cormio G, Piscitelli D, Ciampolillo A, Resta L, Selvaggi L. Large-cell variant of small cell carcinoma of the ovary with hypercalcaemia. Arch Gynecol Obstet. 2000 Nov;264(3):157–8.

    Article  PubMed  Google Scholar 

  10. Aguirre P, Thor AD, Scully RE. Ovarian small cell carcinoma. Histogenetic considerations based on immunohistochemical and other findings. Am J Clin Pathol. 1989 Aug;92(2):140–9.

    PubMed  CAS  Google Scholar 

  11. Choi YL, Kim HS, Ahn G. Immunoexpression of inhibin alpha subunit, inhibin/activin betaA subunit and CD99 in ovarian tumors. Arch Pathol Lab Med. 2000 Apr;124(4):563–9.

    PubMed  CAS  Google Scholar 

  12. Eichhorn JH, Young RH, Scully RE. Primary ovarian small cell carcinoma of pulmonary type. A clinicopathologic, immunohistologic, and flow cytometric analysis of 11 cases. Am J Surg Pathol. 1992 Oct;16(10):926–38.

    Article  PubMed  CAS  Google Scholar 

  13. Crowder S, Tuller E. Small cell carcinoma of the female genital tract. Semin Oncol. 2007 Feb;34(1):57–63. Review.

    Article  PubMed  CAS  Google Scholar 

  14. Eichhorn JH, Young RH. Neuroendocrine tumors of the genital tract. Am J Clin Pathol. 2001 Jun;115 Suppl:S94–112. Review.

    PubMed  CAS  Google Scholar 

  15. Mebis J, De Raeve H, Baekelandt M, Tjalma WA, Vermorken JB. Primary ovarian small cell carcinoma of the pulmonary type: a case report and review of the literature. Eur J Gynaecol Oncol. 2004;25(2):239–41. Review.

    PubMed  CAS  Google Scholar 

  16. Eichhorn JH, Lawrence WD, Young RH, Scully RE. Ovarian neuroendocrine carcinomas of non-small-cell type associated with surface epithelial adenocarcinomas. A study of five cases and review of the literature. Int J Gynecol Pathol. 1996 Oct;15(4):303–14. Review.

    Article  PubMed  CAS  Google Scholar 

  17. Lindboe CF. Large cell neuroendocrine carcinoma of the ovary. APMIS. 2007 Feb;115(2):169–76.

    Article  PubMed  CAS  Google Scholar 

  18. Veras E, Deavers MT, Silva EG, Malpica A. Ovarian nonsmall cell neuroendocrine carcinoma: a clinicopathologic and immunohistochemical study of 11 cases. Am J Surg Pathol. 2007 May;31(5):774–82.

    Article  PubMed  Google Scholar 

  19. Soga J, Osaka M, Yakuwa Y. Carcinoids of the ovary: an analysis of 329 reported cases. J Exp Clin Cancer Res. 2000 Sep;19(3):271–80.

    PubMed  CAS  Google Scholar 

  20. Davis KP, Hartmann LK, Keeney GL, Shapiro H. Primary ovarian carcinoid tumors. Gynecol Oncol. 1996 May;61(2):259–65. Review.

    Article  PubMed  CAS  Google Scholar 

  21. Robboy SJ, Scully RE, Norris HJ. Carcinoid metastatic to the ovary. A clinocopathologic analysis of 35 cases. Cancer. 1974 Mar;33(3):798–811.

    Article  PubMed  CAS  Google Scholar 

  22. Robboy SJ, Norris HJ, Scully RE. Insular carcinoid primary in the ovary. A clinicopathologic analysis of 48 cases. Cancer. 1975 Aug;36(2):404–18.

    Article  PubMed  CAS  Google Scholar 

  23. Robboy SJ, Scully RE, Norris HJ. Primary trabecular carcinoid of the ovary. Obstet Gynecol. 1977 Feb;49(2):202–7.

    PubMed  CAS  Google Scholar 

  24. Alenghat E, Okagaki T, Talerman A. Primary mucinous carcinoid tumor of the ovary. Cancer. 1986 Aug 1;58(3):777–83.

    Article  PubMed  CAS  Google Scholar 

  25. Robboy SJ, Scully RE. Strumal carcinoid of the ovary: an analysis of 50 cases of a distinctive tumor composed of thyroid tissue and carcinoid. Cancer. 1980 Nov 1;46(9):2019–34.

    Article  PubMed  CAS  Google Scholar 

  26. Motoyama T, Katayama Y, Watanabe H, Okazaki E, Shibuya H. Functioning ovarian carcinoids induce severe constipation. Cancer. 1992 Jul 15;70(2):513–8.

    Article  PubMed  CAS  Google Scholar 

  27. Yaegashi N, Tsuiki A, Shimizu T, Kobayashi N, Sato S, Namiki T, Motoyama T, Katayama Y, Yajima A. Ovarian carcinoid with severe constipation due to peptide YY production. Gynecol Oncol. 1995 Feb;56(2):302–6.

    Article  PubMed  CAS  Google Scholar 

  28. Sporrong B, Falkmer S, Robboy SJ, Alumets J, Håkanson R, Ljungberg O, Sundler F. Neurohormonal peptides in ovarian carcinoids: an immunohistochemical study of 81 primary carcinoids and of intraovarian metastases from six mid-gut carcinoids. Cancer. 1982 Jan 1;49(1):68–74.

    Article  Google Scholar 

  29. Sidhu J, Sánchez RL. Prostatic acid phosphatase in strumal carcinoids of the ovary. An immunohistochemical study. Cancer. 1993 Sep 1;72(5):1673–8.

    Article  PubMed  CAS  Google Scholar 

  30. Basham KL, Hajdu SI, Teichberg S, Menzin A. Adenocarcinoid tumor of the ovary diagnosed during pregnancy. A case report. J Reprod Med. 2000 Sep;45(9):758–61.

    PubMed  CAS  Google Scholar 

  31. Baker PM, Oliva E, Young RH, Talerman A, Scully RE. Ovarian mucinous carcinoids including some with a carcinomatous component: a report of 17 cases. Am J Surg Pathol. 2001 May;25(5):557–68.

    Article  PubMed  CAS  Google Scholar 

  32. Modlin IM, Shapiro MD, Kidd M. An analysis of rare carcinoid tumors: clarifying these clinical conundrums. World J Surg. 2005 Jan;29(1):92–101. Review.

    Article  PubMed  Google Scholar 

  33. Astall EC, Brewster JA, Lonsdale R. Malignant carcinoid tumour arising in a mature teratoma of the fallopian tube. Histopathology. 2000 Mar;36(3):282–3.

    Article  PubMed  CAS  Google Scholar 

  34. Alvarado-Cabrero I, Young RH, Vamvakas EC, Scully RE. Carcinoma of the fallopian tube: a clinicopathological study of 105 cases with observations on staging and prognostic factors. Gynecol Oncol. 1999 Mar;72(3):367–79.

    Article  PubMed  CAS  Google Scholar 

  35. Albores-Saavedra J, Gersell D, Gilks CB, Henson DE, Lindberg G, Santiago H, Scully RE, Silva E, Sobin LH, Tavassoli FJ, Travis WD, Woodruff JM. Terminology of endocrine tumors of the uterine cervix: results of a workshop sponsored by the College of American Pathologists and the National Cancer Institute. Arch Pathol Lab Med. 1997 Jan;121(1):34–9. Review.

    PubMed  CAS  Google Scholar 

  36. Ueda G, Yamasaki M. Neuroendocrine carcinoma of the uterus. Curr Top Pathol. 1992;85:309–35. Review.

    Article  PubMed  CAS  Google Scholar 

  37. Collinet P, Lanvin D, Declerck D, Chevalier-Place A, Leblanc E, Querleu D. Neuroendocrine tumors of the uterine cervix. Clinicopathologic study of five patients. Eur J Obstet Gynecol Reprod Biol. 2000 Jul;91(1):51–7.

    Article  PubMed  CAS  Google Scholar 

  38. Stoler MH, Mills SE, Gersell DJ, Walker AN. Small-cell neuroendocrine carcinoma of the cervix. A human papillomavirus type 18-associated cancer. Am J Surg Pathol. 1991 Jan;15(1):28–32.

    Article  PubMed  CAS  Google Scholar 

  39. Ambros RA, Park JS, Shah KV, Kurman RJ. Evaluation of histologic, morphometric, and immunohistochemical criteria in the differential diagnosis of small cell carcinomas of the cervix with particular reference to human papillomavirus types 16 and 18. Mod Pathol. 1991 Sep;4(5):586–93. Erratum in: Mod Pathol 1992 Jan;5(1):40.

    PubMed  CAS  Google Scholar 

  40. Albores-Saavedra J, Rodríguez-Martínez HA, Larraza-Hernández O. Carcinoid tumors of the cervix. Pathol Annu. 1979;14 Pt 1:273–91. Review.

    PubMed  Google Scholar 

  41. Stockdale AD, Leader M, Phillips RH, Henry K. The carcinoid syndrome and multiple hormone secretion associated with a carcinoid tumour of the uterine cervix. Case report. Br J Obstet Gynaecol. 1986 Apr;93(4):397–401.

    PubMed  CAS  Google Scholar 

  42. Koch CA, Azumi N, Furlong MA, Jha RC, Kehoe TE, Trowbridge CH, O’Dorisio TM, Chrousos GP, Clement SC. Carcinoid syndrome caused by an atypical carcinoid of the uterine cervix. J Clin Endocrinol Metab. 1999 Nov;84(11):4209–13.

    Article  PubMed  CAS  Google Scholar 

  43. van Nagell JR Jr, Powell DE, Gallion HH, Elliott DG, Donaldson ES, Carpenter AE, Higgins RV, Kryscio R, Pavlik EJ. Small cell carcinoma of the uterine cervix. Cancer. 1988 Oct 15;62(8):1586–93.

    Article  PubMed  Google Scholar 

  44. Gersell DJ, Mazoujian G, Mutch DG, Rudloff MA. Small-cell undifferentiated carcinoma of the cervix. A clinicopathologic, ultrastructural, and immunocytochemical study of 15 cases. Am J Surg Pathol. 1988 Sep;12(9):684–98.

    Article  PubMed  CAS  Google Scholar 

  45. Abeler VM, Holm R, Nesland JM, Kjørstad KE. Small cell carcinoma of the cervix. A clinicopathologic study of 26 patients. Cancer. 1994 Feb 1;73(3):672–7.

    Article  PubMed  CAS  Google Scholar 

  46. Sykes AJ, Shanks JH, Davidson SE. Small cell carcinoma of the uterine cervix: a clinicopathological review. Int J Oncol. 1999 Feb;14(2):381–6.

    PubMed  CAS  Google Scholar 

  47. Delaloge S, Pautier P, Kerbrat P, Castaigne D, Haie-Meder C, Duvillard P, Guivarch C, Goupil A, Borel C, Lhommé C. Neuroendocrine small cell carcinoma of the uterine cervix: what disease? What treatment? Report of ten cases and a review of the literature. Clin Oncol (R Coll Radiol). 2000;12(6):357–62. Review.

    Article  CAS  Google Scholar 

  48. Conner MG, Richter H, Moran CA, Hameed A, Albores-Saavedra J. Small cell carcinoma of the cervix: a clinicopathologic and immunohistochemical study of 23 cases. Ann Diagn Pathol. 2002 Dec;6(6):345–8.

    Article  PubMed  Google Scholar 

  49. Weed JC Jr, Graff AT, Shoup B, Tawfik O. Small cell undifferentiated (neuroendocrine) carcinoma of the uterine cervix. J Am Coll Surg. 2003 Jul;197(1):44–51.

    Article  PubMed  Google Scholar 

  50. Ishida GM, Kato N, Hayasaka T, Saito M, Kobayashi H, Katayama Y, Sasou S, Yaegashi N, Kurachi H, Motoyama T. Small cell neuroendocrine carcinomas of the uterine cervix: a histological, immunohistochemical, and molecular genetic study. Int J Gynecol Pathol. 2004 Oct;23(4):366–72.

    Article  PubMed  Google Scholar 

  51. Viswanathan AN, Deavers MT, Jhingran A, Ramirez PT, Levenback C, Eifel PJ. Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence. Gynecol Oncol. 2004 Apr;93(1):27–33.

    Article  PubMed  CAS  Google Scholar 

  52. Tsunoda S, Jobo T, Arai M, Imai M, Kanai T, Tamura T, Watanabe J, Obokata A, Kuramoto H. Small-cell carcinoma of the uterine cervix: a clinicopathologic study of 11 cases. Int J Gynecol Cancer. 2005 Mar–Apr;15(2):295–300.

    Article  PubMed  CAS  Google Scholar 

  53. Gilks CB, Young RH, Gersell DJ, Clement PB. Large cell neuroendocrine [corrected] carcinoma of the uterine cervix: a clinicopathologic study of 12 cases. Am J Surg Pathol. 1997 Aug;21(8):905–14. Erratum in: 1997 Oct;21(10):1260.

    Article  PubMed  CAS  Google Scholar 

  54. Krivak TC, McBroom JW, Sundborg MJ, Crothers B, Parker MF. Large cell neuroendocrine cervical carcinoma: a report of two cases and review of the literature. Gynecol Oncol. 2001 Jul;82(1):187–91. Review.

    Article  PubMed  CAS  Google Scholar 

  55. Sato Y, Shimamoto T, Amada S, Asada Y, Hayashi T. Large cell neuroendocrine carcinoma of the uterine cervix: a clinicopathological study of six cases. Int J Gynecol Pathol. 2003 Jul;22(3):226–30.

    Article  PubMed  Google Scholar 

  56. Dikmen Y, Kazandi M, Zekioglu O, Ozsaran A, Terek MC, Erhan Y. Large cell neuroendocrine carcinoma of the uterine cervix: a report of a case and review of the literature. Arch Gynecol Obstet. 2004 Nov;270(3):185–8. Epub 2003 Apr 25. Review.

    Article  PubMed  Google Scholar 

  57. Cetiner H, Kir G, Akoz I, Gurbuz A, Karateke A. Large-cell neuroendocrine carcinoma of the cervix associated with cervical-type invasive adenocarcinoma: a report of case and discussion of histogenesis. Int J Gynecol Cancer. 2006 Jan–Feb;16(1):438–42. Review.

    Article  PubMed  CAS  Google Scholar 

  58. McCluggage WG, Sargent A, Bailey A, Wilson GE. Large cell neuroendocrine carcinoma of the uterine cervix exhibiting TTF1 immunoreactivity. Histopathology. 2007 Sep;51(3):405–7.

    Article  PubMed  CAS  Google Scholar 

  59. Chetty R, Clark SP, Bhathal PS. Carcinoid tumour of the uterine corpus. Virchows Arch A Pathol Anat Histopathol. 1993;422(1):93–5.

    Article  PubMed  CAS  Google Scholar 

  60. Campo E, Brunier MN, Merino MJ. Small cell carcinoma of the endometrium with associated ocular paraneoplastic syndrome. Cancer. 1992 May 1;69(9):2283–8. Review.

    Article  PubMed  CAS  Google Scholar 

  61. Huntsman DG, Clement PB, Gilks CB, Scully RE. Small-cell carcinoma of the endometrium. A clinicopathological study of sixteen cases. Am J Surg Pathol. 1994 Apr;18(4):364–75. Review.

    Article  PubMed  CAS  Google Scholar 

  62. van Hoeven KH, Hudock JA, Woodruff JM, Suhrland MJ. Small cell neuroendocrine carcinoma of the endometrium. Int J Gynecol Pathol. 1995 Jan;14(1):21–9. Review.

    Article  PubMed  Google Scholar 

  63. Varras M, Akrivis Ch, Demou A, Hadjopoulos G, Stefanaki S, Antoniou N. Primary small-cell carcinoma of the endometrium: clinicopathological study of a case and review of the literature. Eur J Gynaecol Oncol. 2002;23(6):577–81. Review.

    PubMed  CAS  Google Scholar 

  64. Katahira A, Akahira J, Niikura H, Ito K, Moriya T, Matsuzawa S, Makinoda S, Oda T, Fujiwara K, Yaegashi N. Small cell carcinoma of the endometrium: report of three cases and literature review. Int J Gynecol Cancer. 2004 Sep–Oct;14(5):1018–23.

    Article  PubMed  CAS  Google Scholar 

  65. Sulak P, Barnhill D, Heller P, Weiser E, Hoskins W, Park R, Woodward J. Nonsquamous cancer of the vagina. Gynecol Oncol. 1988 Mar;29(3):309–20.

    Article  PubMed  CAS  Google Scholar 

  66. Rusthoven JJ, Daya D. Small-cell carcinoma of the vagina. A clinicopathologic study. Arch Pathol Lab Med. 1990 Jul;114(7):728–31.

    PubMed  CAS  Google Scholar 

  67. Colleran KM, Burge MR, Crooks LA, Dorin RI. Small cell carcinoma of the vagina causing Cushing's syndrome by ectopic production and secretion of ACTH: a case report. Gynecol Oncol. 1997 Jun;65(3):526–9.

    Article  PubMed  CAS  Google Scholar 

  68. Kaminski JM, Anderson PR, Han AC, Mitra RK, Rosenblum NG, Edelson MI. Primary small cell carcinoma of the vagina. Gynecol Oncol. 2003 Mar;88(3):451–5. Review.

    Article  PubMed  Google Scholar 

  69. Bing Z, Levine L, Lucci JA, Hatch SS, Eltorky MA. Primary small cell neuroendocrine carcinoma of the vagina: a clinicopathologic study. Arch Pathol Lab Med. 2004 Aug;128(8):857–62. Review.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. NYU School of Medicine and Hospitals, Bellevue Hospital – Building H, Room 4west, NY 10016, USA

    Khush Mittal (Associate Professor of Pathology)

  2. Department of Surgical and Ob-Gyn pathology, NYU School of Medicine and Hospitals, Bellevue Hospital - Building H, Room 4west, NY 10016, USA

    Fan Chen (Clinical Assistant Professor)

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  1. Khush Mittal
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Correspondence to Khush Mittal .

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  1. School (UMMS), University of Massachusetts Medical, Lake Avenue N. 55, Worcester, 01655, U.S.A.

    Ashraf Khan

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Mittal, K., Chen, F. (2009). Neuroendocrine Tumors of Female Genital Tract. In: Khan, A. (eds) Surgical Pathology of Endocrine and Neuroendocrine Tumors. Current Clinical Pathology. Humana Press. https://doi.org/10.1007/978-1-60327-396-1_14

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  • DOI: https://doi.org/10.1007/978-1-60327-396-1_14

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