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Targeted and Functional Imaging

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Targeted Cancer Therapy

Part of the book series: Current Clinical Oncology™ ((CCO))

Abstract

The emerging field of targeted therapy is ushering in a new era of targeted/functional imaging, which compliments and sometimes improves upon traditional anatomic imaging for diagnosis, early assessment of treatment response, and estimation of durability of therapeutic success. Targeted/functional imaging has already had an impact on clinical management. With such methods, one may either measure the target directly or assess downstream effects. The former may provide greater specificity, whereas, the latter may have broader applicability. The clinical question will guide selection between the two. The primary modalities currently used clinically include nuclear medicine techniques, such as planar or single photon emission computed tomography or positron emission tomography, and MR based techniques, such as dynamic contrast enhanced MR imaging. An understanding of the physics and clinical applications of targeted/functional imaging and their requisite molecular imaging agents aides image interpretation. Combining such imaging with anatomic imaging is often advantageous. For the future, clinical trials of targeted/functional imaging are needed in addition to and in parallel with clinical trials of targeted therapeutics given the obvious synergy between the two.

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Authors
  1. Vikas Kundra MD
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  2. Dawid Schellingerhout MD
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  3. Edward F. Jackson MD
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Editor information

Editors and Affiliations

  1. Department of Investigational Cancer Therapeutics Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

    Razelle Kurzrock MD

  2. Department of Clinical Research, The University of Texas MD Anderson Cancer Center, Houston, TX

    Maurie Markman

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© 2008 Humana Press, Totowa, NJ

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Kundra, V., Schellingerhout, D., Jackson, E. (2008). Targeted and Functional Imaging. In: Kurzrock, R., Markman, M. (eds) Targeted Cancer Therapy. Current Clinical Oncology™. Humana Press. https://doi.org/10.1007/978-1-60327-424-1_17

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  • DOI: https://doi.org/10.1007/978-1-60327-424-1_17

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-423-4

  • Online ISBN: 978-1-60327-424-1

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