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New Findings in the Diagnosis and Prevention of Colorectal Cancer in IBD

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Inflammatory Bowel Disease

Part of the book series: Clinical Gastroenterology ((CG))

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Abstract

The risk of colorectal cancer in chronic ulcerative colitis and Crohn’s disease of the colon is increased compared to the noninflammatory bowel disease ­population, but appears to be less than previous estimates. Our current approach is secondary prevention with screening and ­surveillance colonoscopies, yet this approach remains inaccurate and time consuming. Unlike traditional teaching, dysplasia of the colon in colitis is visible with ­current technologies, and can be identified with greater success using dye-spray chromoendoscopy. The evolving understanding of dysplasia detection may allow some patients with dysplasia to be followed with serial examinations rather than undergoing colectomy. Incorporation of degree of inflammation into prevention strategies will enable risk stratification for future follow-up. Chemoprevention with aminosalicylates remains a great interest. The role of other medical therapies in primary cancer prevention has been insufficiently studied.

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Authors and Affiliations

  1. Section of Gastroenterology, Department of Medicine, University of Chicago Medical Center, 5841 South Maryland Avenue, MC4076, Chicago, IL, 60637, USA

    David T. Rubin

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  1. David T. Rubin
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  2. Jami A. Rothe
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Correspondence to David T. Rubin .

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  1. MC 4076, Sect. Of GE, Hepatol. & Nutr., Department of Medicine, University of Chicago Medical Center, S. Maryland Ave. 5841, Chicago, 60637, Illinois, USA

    Russell D. Cohen

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Rubin, D.T., Rothe, J.A. (2011). New Findings in the Diagnosis and Prevention of Colorectal Cancer in IBD. In: Cohen, R. (eds) Inflammatory Bowel Disease. Clinical Gastroenterology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-433-3_17

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  • DOI: https://doi.org/10.1007/978-1-60327-433-3_17

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