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An Experimental Model of Myocardial and Cerebral Global Ischemia and Reperfusion

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Abstract

Despite many programs aimed at better immediate care of cardiac arrest victims, the subsequent mortality rate remains high, with myocardial and central nervous system injuries as the most common causes of death. Preclinical research is badly needed to produce a sound base for future clinical trials and possible improvements in clinical outcome. Our continued use of a porcine model for studies of cerebral effects of anoxia and reperfusion has shown that this model results in standardized effects, where time of cardiac arrest and reperfusion are approximately proportional to the ischemic neurological injury. Free radical damage is proved to be an important pathophysiological mechanism in the early development of this nervous injury. Hence, not unexpectedly, early experimental treatment after total ischemia during early reperfusion results in improved measures of cerebral tissue damage.

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Acknowledgment

Continued financial support over the years from The Laerdal Foundation for Acute Medicine is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Surgical Sciences/Anaesthesiology and Intensive Care Medicine, Uppsala University, 751 85, Uppsala, Sweden

    Lars Wiklund

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  1. Lars Wiklund
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  2. Samar Basu
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Correspondence to Lars Wiklund .

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Editors and Affiliations

  1. Dept. Health & Caring Sciences, University Uppsala, Döbelnsgatan 2, Uppsala, 752 37, Sweden

    Samar Basu

  2. Dept. Surgical Sciences, Anaesthesiology, & Intensive Care, Uppsala University Hospital, Akademiska Sjukhuset, Uppsala, 751 85, Sweden

    Lars Wiklund

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Wiklund, L., Basu, S. (2011). An Experimental Model of Myocardial and Cerebral Global Ischemia and Reperfusion. In: Basu, S., Wiklund, L. (eds) Studies on Experimental Models. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-956-7_13

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