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Spermatogonial Stem Cells

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Advances in Stem Cell Research

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

The process of spermatogenesis is initiated and maintained by a rare population of single spermatogonial stem cells (SSCs). The SSCs are attached to the basement membrane of the seminiferous tubules and are characterized by typical morphological criteria. SSCs are the important starting point as part of a robust stem cell system of the testis involved in spermatogenesis and reproduction. The isolation and cultivation of human SSCs would significantly contribute to the increasing knowledge of human germ and stem cell biology. Although still a difficult task, the newly established enrichment and in vitro propagation of spermatogonia that carry the male genome from generation to generation provides an important step for future transplantation and restoration of fertility in the clinic.

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Authors and Affiliations

  1. Institute for Anatomy and Cell Biology, University of Heidelberg, Heidelberg, Germany

    Hossein Azizi & Thomas Skutella

  2. Insitute of Anatomy, University of Tübingen, Tübingen, Germany

    Sabine Conrad

  3. Department of Obstetrics and Gynaecology, University Medical Centre Ljubljana, Ljubljana, Slovenia

    Irma Virant-Klun

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  1. Hossein Azizi
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  2. Sabine Conrad
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  3. Thomas Skutella
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  4. Irma Virant-Klun
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Correspondence to Thomas Skutella .

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Editors and Affiliations

  1. Royan Institute, Department of Developmental Biology, University of Science and Culture, PO Box 19395-4644, Tehran, Iran

    Hossein Baharvand

  2. , Regenerative Medicine, Royan Institute for Stem Cell Biology an, P.O. Box: 19395-4644, Tehran, Iran

    Nasser Aghdami

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Azizi, H., Conrad, S., Skutella, T., Virant-Klun, I. (2012). Spermatogonial Stem Cells. In: Baharvand, H., Aghdami, N. (eds) Advances in Stem Cell Research. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-940-2_11

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