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Stem Cell Therapy for Bone Disorders

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Mesenchymal Stem Cell Therapy

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Stem cells of various origins have shown enormous potential to enhance bone repair and regeneration. From fracture healing to bone loss, including well-known medical conditions like osteoporosis, stem cells are being applied more and more frequently. Furthermore, they are being proposed for the treatment of genetic bone disorders with satisfactory outcomes. However, key questions remain on the type of cell to use, and the isolation and expansion protocols to select. Moreover, the in vitro modification of the cells to induce a specific phenotype, enabling regeneration of new bone is being matter of extensive research. In that respect, a possibility also exists for the enhancement of vascularization during bone regeneration events by using coculture systems or endothelial-based cell therapies. It is our intention in this chapter, to bring to the reader an update on the use of stem cells to treat bone disorders. In light of that, important concepts and definitions will be presented, as well as some examples of relevant findings. Finally, clinical trials on this topic will be discussed.

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Author information

Authors and Affiliations

  1. Institute for Experimental Oncology and Therapy Research, Klinikum rechts der Isar, Technical University Munich, Munich, Germany

    Elizabeth Rosado Balmayor

  2. ethris GmbH, Martinsried, Germany

    Elizabeth Rosado Balmayor

  3. Institute for Experimental Trauma Surgery, Clinic for Trauma Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany

    Martijn van Griensven

Authors
  1. Elizabeth Rosado Balmayor
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  2. Martijn van Griensven
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Correspondence to Elizabeth Rosado Balmayor .

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Editors and Affiliations

  1. Cellular Dynamics International, Inc., Science Drive 525, Madison, 53711, Wisconsin, USA

    Lucas G. Chase

  2. , Stem Cells and Regenerative Medicine, Life Technologies, Executive Way 7335, Frederick, 21704, Maryland, USA

    Mohan C. Vemuri

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Balmayor, E.R., van Griensven, M. (2013). Stem Cell Therapy for Bone Disorders. In: Chase, L., Vemuri, M. (eds) Mesenchymal Stem Cell Therapy. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-200-1_6

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