Skip to main content
SpringerLink
Log in

Overactive Bladder

  • Chapter
Pelvic Floor Re-education

  • 2625 Accesses

Abstract

Overactive bladder (OAB) is defined as urgency, with or without urge incontinence, usually with frequency and nocturia.1 It is a common condition with a significant impact on the quality of life.2 There are two primary approaches to the treatment of OAB; behavioral interventions and pharmacologic therapies. Both have been shown to produce significant reduction of OAB symptoms in large numbers of patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abrams P, Cardozo L, Fall M, et al. The standardisation of terminology of lower urinary tract function. Report from the standardisation subcommittee of the International Continence Society. Urology. 2003;61:37.

    Google Scholar 

  2. Stewart WF, Van Rooyen JB, Cundiff GW, et al. Prevalence and burden of overactive bladder in the United States. World J Urol. 2003;20:327

    CAS  PubMed  Google Scholar 

  3. Frewen WK. Role of bladder training in the treatment of the unstable bladder in the female. Urol Clin North Am. 1979;6:273–277.

    CAS  PubMed  Google Scholar 

  4. Jarvis GJ, Millar DR. Controlled trial of bladder drill for detrusor instability. Br Med J. 1980;281: 322–1323.

    Article  Google Scholar 

  5. Pengelly AW, Booth CM. A prospective trial of bladder training as treatment for detrusor instability. Br J Urol. 1980;52:463–466.

    Article  CAS  PubMed  Google Scholar 

  6. Fantl JA, Wyman JF, McClish DK, et al. Efficacy of bladder training in older women with urinary incontinence. JAMA. 1991;265:609–613.

    Article  CAS  PubMed  Google Scholar 

  7. Burgio KL, Whitehead WE, Engel BT. Urinary incontinence in the elderly: bladder/sphincter biofeedback and toileting skills training. Ann Intern Med 1985;103:507–515.

    CAS  PubMed  Google Scholar 

  8. Burgio KL, Goode PS, Locher JL, et al. Behavioral training with and without biofeedback in the treatment of urge incontinence in older women: a randomized, controlled trial. JAMA. 2002;288:2293–2299.

    Article  PubMed  Google Scholar 

  9. Burgio KL, Pearce KL, Lucco A. Staying dry: A practical guide to bladder control. Baltimore: The Johns Hopkins University Press; 1989.

    Google Scholar 

  10. Burton JR, Pearce KL, Burgio KL, et al. Behavioral training for urinary incontinence in elderly ambulatory patients. J Am Geriatr Soc. 1988;36:693–698.

    CAS  PubMed  Google Scholar 

  11. Burgio KL, Locher JL. Goode PS, et al. Behavioral vs. drug treatment for urge urinary incontinence in older women: a randomized controlled trial. JAMA. 1998;280:1995–2000.

    Article  CAS  PubMed  Google Scholar 

  12. Johnson TM, Burgio KL, Goode PS, et al. Effects of behavioral and drug therapy on nocturia in older incontinent women. J Am Geriatr Soc. 2005;53:846–850.

    Article  PubMed  Google Scholar 

  13. Moore KH, Hay DM, Imrie AE, et al. Oxybutynin hydrochloride (3 mg) in the treatment of women with idiopathic detrusor instability. Br J Urol. 1990;66:479–485.

    Article  CAS  PubMed  Google Scholar 

  14. Tapp AJS, Cardozo LD, Versi E, et al. The treatment of detrusor instability in post menopausal women with oxybutynin chloride: a double blind placebo-controlled study. Br J Obstet Gynaecol. 1990;97:479–485.

    Google Scholar 

  15. Thuroff JW, Bunke B, Ebner A, et al. Randomized, double-blind, multicentre trial on treatment of frequency, urgency and incontinence related to detrusor hyperactivity: oxybutynin versus propantheline versus placebo. J Urol. 1991;145;813–817.

    CAS  PubMed  Google Scholar 

  16. Madersbacher H, Halaska M, Voigt R, et al. A placebo-controlled, multicentre study comparing the tolerability and efficacy of propiverine and oxybutynin in patients with urgency and urge incontinence. BJU Int. 1999;84:646–651.

    Article  CAS  PubMed  Google Scholar 

  17. Anderson RU, Mobley D, Blank B, et al. Once daily controlled versus immediate release oxybutynin chloride for urge urinary incontinence. OROS Oxybutynin Study Group J Urol. 1999;161:809–1812.

    Google Scholar 

  18. Gleason DM, Susset J, White C, et al. Evaluation of a new once-daily formulation of oxybutynin for the treatment of urinary urge incontinence. Ditropan XL Study Group. Urology. 1999;54:420–423.

    Article  CAS  PubMed  Google Scholar 

  19. Dmochowski RR, Sand PK, Zinner NR, et al. Transdermal Oxybutynin Study Group. Comparative efficacy and safety of transdermal oxybutynin and oral tolterodine versus placebo in previously treated patients with urge and mixed urinary incontinence. Urology. 2003;62:237–242.

    Article  PubMed  Google Scholar 

  20. Stoher M, Madersbacher H, Richter R, et al. Efficacy and safety of propiverine in SCI-patients suffering from detrusor hyperreflexia: a double-blind, placebo-controlled clinical trial. Spinal Cord. 1999;37:196–200.

    Article  Google Scholar 

  21. Millard R, Tuttle J, Moore K, et al. Clinical efficacy and safety of tolterodine compared to placebo in detrusor overactivity. J Urol. 1999;161:1551–1555.

    Article  CAS  PubMed  Google Scholar 

  22. Rentzhog L. Stanton SL, Cardozo LD, et al. Efficacy and safety of tolterodine in patients with detrusor instability: a dose ranging study. Br J Urol. 1998;81:42–48.

    CAS  PubMed  Google Scholar 

  23. Abrams P, Freeman R, Anderstrom C, et al. Tolterodine, a new antimuscarinic agent: as effective but better tolerated than oxybutynin in patients with an overactive bladder. Br J Urol. 1998;81:801–810.

    CAS  PubMed  Google Scholar 

  24. Van Kerrebroeck P, Kreder K, Jonas U, et al. Tolt-erodine Study Group. Tolterodine once-daily: superior efficacy and tolerability in the treatment of overactive bladder. Urology. 2001;57:414–421.

    Article  PubMed  Google Scholar 

  25. Diokno AC, Appell RA, Sand PK, et al. OPERA Study Group. Prospective, randomised, double blind study of the efficacy and tolerability of the extended-release formulations of oxybutynin and tolterodine for overactive bladder: results of the OPERA trial. Mayo Clin Proc. 2003;78:687–695.

    Article  CAS  PubMed  Google Scholar 

  26. Cardozo LD, Chapple CR, Toozs-Hobson P, et al. Efficacy of trospium chloride in patients with detrusor instability: a placebo-controlled, randomized, double-blind, multicentre clinical trial. BJU Int. 2000;85:659–664.

    Article  CAS  PubMed  Google Scholar 

  27. Madersbacher H, Stoher M, Richter R, et al. Trospium chloride versus oxybutynin: a randomized, double-blind, multicentre trial in the treatment of detrusor hyperreflexia. Br J Urol 1995;75:452–456.

    Article  CAS  PubMed  Google Scholar 

  28. Ikeda K, Kobayashi S. Effects of YM905, Oxybutynin and Darifenacin on carbachol induced intracellular calcium mobilization by dispersed longitudinal smooth muscle cells of guinea pig colon. Yamanouchi Pharmaceutical Co. (1998). Registration No. D199803320-02.00. International Study ID: 905-PH-006.

    Google Scholar 

  29. Ikeda K, Kobayashi S. Effects of YM905, tolterodine and Oxybutynin on M3 receptor mediated cytosolic free Ca2+mobilization in acutely dissociated cells of guinea pig urinary bladder smooth muscle and murine submandibular gland. Yamanouchi Pharmaceutical Co. (1998). Registration No. D199803217-02.000. International Study ID: 905-PH-005.

    Google Scholar 

  30. Chapple C, Martinez-Garcia R Selvaggi L, et al A comparison of the efficacy and tolerability of Solifenacin Succinate and extended release Tolterodine at treating overactive bladder syndrome: results of the S.T.A.R trial. Eur Urol. 2005;48:464–470.

    CAS  PubMed  Google Scholar 

  31. Rosario DJ, Leaker BR, Smith DJ, et al. A pilot study of the effects of multiple doses of the M3 muscarinic receptor antagonist darifenacin on ambulatory parameters of detrusor activity in patients with detrusor instability. Neurourol Urodyn. 1995;14:464–465.

    Google Scholar 

  32. Castleden CM, Duffin HM, Gulati RS. Double-blind study of imipramine and placebo for incontinence due to bladder instability. Age Ageing. 1986;15:299–303.

    Article  CAS  PubMed  Google Scholar 

  33. Robinson D, Cardozo L, Akeson M, et al. Women take control; Desmopressin — A drug for daytime urinary incontinence. Neurourol Urodyn. 2002;21:385–386.

    Article  Google Scholar 

  34. Mattiasson AJ, et al. Simplified bladder training augments the effectiveness of tolterodine in patients with an overactive bladder. BJU Int. 2003;91:54–60.

    Article  CAS  PubMed  Google Scholar 

  35. Burgio KL, Locher JL, Goode PS. Combined behavioral and drug therapy for urge incontinence in older women. J Am Geriatr Soc. 2000;48:370–374.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urogynaecology, Kings College Hospital, London, UK

    Dudley Robinson MBBS, MRCOG & Linda Cardozo MD, FRCOG

  2. Division of Gerontology, Geriatrics and Palliative Care Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

    Kathryn L. Burgio PhD

  3. Geriatric Research, Education, and Clinical Center, Birmingham VA Medical Center, Birmingham, AL, USA

    Kathryn L. Burgio PhD

Authors
  1. Kathryn L. Burgio PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dudley Robinson MBBS, MRCOG
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Linda Cardozo MD, FRCOG
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Gynaecology, Charité University Hospital, Berlin, Germany

    Kaven Baessler MD (Consultant Gynaecologist) (Consultant Gynaecologist)

  2. Division of Gerontology, Geriatrics and Palliative Care Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

    Kathryn L. Burgio PhD (Professor of Medicine, Associate Director) (Professor of Medicine, Associate Director)

  3. Geriatric Research, Education and Clinical Center, University of Alabama at Birmingham, Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA

    Kathryn L. Burgio PhD (Professor of Medicine, Associate Director) (Professor of Medicine, Associate Director)

  4. Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT, USA

    Peggy A. Norton MD (Professor Chief of Urogynecology and Reconstructive Pelvic Surgery) (Professor Chief of Urogynecology and Reconstructive Pelvic Surgery)

  5. Neue Frauenklinik, Kantonsspital Luzern, Luzern, Switzerland

    Bernhard Schüssler MD, PhD (Professor of Obstetrics and Gynaecology) (Professor of Obstetrics and Gynaecology)

  6. Department of Urogynaecology, University of New South Wales St George Hospital, Sydney, NSW, Australia

    Kate H. Moore MBBS, MD, FRCOG, FRANZCOG, CU (Associate Professor) (Associate Professor)

  7. Portland Hospital, London, UK

    Stuart L. Stanton FRCS, FRCOG, FRANZCOG(Hon) (Professor of Pelvic Floor Reconstruction and Urogynaecology) (Professor of Pelvic Floor Reconstruction and Urogynaecology)

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer-Verlag London Limited

About this chapter

Cite this chapter

Burgio, K.L., Robinson, D., Cardozo, L. (2008). Overactive Bladder. In: Baessler, K., Burgio, K.L., Norton, P.A., Schüssler, B., Moore, K.H., Stanton, S.L. (eds) Pelvic Floor Re-education. Springer, London. https://doi.org/10.1007/978-1-84628-505-9_29

Download citation

  • DOI: https://doi.org/10.1007/978-1-84628-505-9_29

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-85233-968-5

  • Online ISBN: 978-1-84628-505-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation