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Basic Science of Breast Cancer in Older Patients

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Management of Breast Cancer in Older Women

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Abstract

Breast cancer is the leading cancer for females in North America and Europe. Although the environment and cultural and ethical backgrounds have an impact on breast cancer frequency, two major risk factors arise above all doubt, namely, increasing age and estrogen exposures. It seems that a cumulative effect of both is leading to the peak of breast cancer incidence in postmenopausal women. In addition, molecular signaling pathways that change with aging might be involved in the predisposition setting. These aging-related signaling pathways and their relation to cancer-related signaling pathways will be discussed here. A second theme will be highlighted in different ways, namely the involvement of the breast cancer predisposition genes in age-dependent incidence of breast cancer.

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Authors and Affiliations

  1. Department of Gynecology and Obstetrics and Department of Medical Genetics and Laboratories, University Hospitals Geneva, Geneva, Switzerland

    Irmgard Irminger-Finger

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  1. Irmgard Irminger-Finger
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Correspondence to Irmgard Irminger-Finger .

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  1. University of Sheffield, Sheffield, S10 2JF, United Kingdom

    Malcolm W. Reed

  2. Marshalls Cross Road, St Helens, WA9 3DA, United Kingdom

    Riccardo A. Audisio

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Irminger-Finger, I. (2010). Basic Science of Breast Cancer in Older Patients. In: Reed, M., Audisio, R. (eds) Management of Breast Cancer in Older Women. Springer, London. https://doi.org/10.1007/978-1-84800-265-4_1

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  • DOI: https://doi.org/10.1007/978-1-84800-265-4_1

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