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Transforming “Waste” into Gold: Identification of Novel Stem Cells Resources with Therapeutic Potential in Neuromuscular Disorders

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Regenerative Medicine Using Pregnancy-Specific Biological Substances

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Abstract

Once considered a biological waste product, umbilical cord blood (UCB) has emerged as a viable source of hematopoietic stem cells for transplantation. At the time of World War II, stored placental blood was explored as a source of blood for transfusion, and found to be similar in effect to fresh adult blood. During the 1970s, it was recognized that UCB contains hematopoietic progenitor cells. The suggestion that cryopreserved UCB could be used as a source of stem cells in much the same way as transplantation of bone marrow paved the way for the first successful human UCB transplant, performed in France in 1988. The recipient remains alive and well 18 years later. Since then, more than 2,000 transplants have been performed worldwide, most using stored units in private or public cord blood banks.

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Authors and Affiliations

  1. Department of Genetic and Evolutive Biology, Human Genome Research Center, University of São Paulo, Rua do Matão, n. 106, São Paulo, Brazil

    Mayana Zatz

Authors
  1. Mariane Secco
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  2. Mayana Zatz
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  3. Natassia Vieira
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Corresponding author

Correspondence to Mayana Zatz .

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Editors and Affiliations

  1. Advanced Medical Research Inst., B.P.Poddar Hospital, Vidyasagar Hospital, Kolkata, India

    Niranjan Bhattacharya

  2. Dept. Obstetrics & Gynaecology, Boston University Medical Centre, E. Concord Street 85, Boston, 02118, Massachusetts, USA

    Phillip Stubblefield

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© 2011 Springer London

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Secco, M., Zatz, M., Vieira, N. (2011). Transforming “Waste” into Gold: Identification of Novel Stem Cells Resources with Therapeutic Potential in Neuromuscular Disorders. In: Bhattacharya, N., Stubblefield, P. (eds) Regenerative Medicine Using Pregnancy-Specific Biological Substances. Springer, London. https://doi.org/10.1007/978-1-84882-718-9_15

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  • DOI: https://doi.org/10.1007/978-1-84882-718-9_15

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84882-717-2

  • Online ISBN: 978-1-84882-718-9

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