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Future of Cardiogenetics

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Clinical Cardiogenetics

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Abstract

During the past years, enormous efforts have been made in population genetics, testing common single nucleotide polymorphisms (SNPS) in large, collaborative, multicenter studies involving tens of thousands of subjects, which have revolutionized the production of genetic data. Genome-wide association studies (GWAS) as the current technology for analysis of complex disease genetics2, have identified novel genes associated with disease and traits. In the field of cardiovascular diseases (CVDs) novel loci were recently found to be associated with coronary artery disease3-5, early onset myocardial infarction6, atrial fibrillation7, 8, left ventricular (LV) structure and function9, stroke10, blood pressure11, 12, and lipid levels.13 Currently, there are a rapidly growing number of genetic associations that achieve very strong statistical support and are replicated in additional, independent studies. These discoveries increase expectations that genetic and genomic information will become an important component of personalized health care and disease prevention, and a great asset to translational research.14-16

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Author information

Authors and Affiliations

  1. Department of Cardiology and Julius Center for Health Science and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

    Mohammad Hadi Zafarmand

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  1. Mohammad Hadi Zafarmand
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  2. K. David Becker
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  3. Pieter A. Doevendans
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Editors and Affiliations

  1. University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, 3508 GA, Netherlands

    H.F. Baars

  2. University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, 3508 GA, Netherlands

    P.A.F.M. Doevendans

  3. University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, 3508 GA, Netherlands

    J.J. van der Smagt

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Zafarmand, M.H., Becker, K.D., Doevendans, P.A. (2011). Future of Cardiogenetics. In: Baars, H., Doevendans, P., van der Smagt, J. (eds) Clinical Cardiogenetics. Springer, London. https://doi.org/10.1007/978-1-84996-471-5_28

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  • DOI: https://doi.org/10.1007/978-1-84996-471-5_28

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