Skip to main content

Pre-rheumatoid arthritis

  • Chapter
  • First Online:
Atlas of Rheumatoid Arthritis

Abstract

In recent years, research in the field of rheumatoid arthritis (RA) has focused on the earliest stages of disease. Different terminologies for preclinical and very early clinical disease stages are used; ‘pre-RA’ is one of these terms. In order to facilitate communication, a European League Against Rheumatism (EULAR) task force has derived recommendations for terminology to be used during the preclinical and earliest clinically apparent phases of RA.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Gerlag DM, Raza K, van Baarsen LG, et al. EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis. Ann Rheum Dis. 2012;71:638-641.

    Google Scholar 

  2. van der Woude D, Houwing-Duistermaat JJ, Toes RE, et al. Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis. Arthritis Rheum. 2009;60:916-923.

    Google Scholar 

  3. Pedersen M, Jacobsen S, Klarlund M, et al. Environmental risk factors differ between rheumatoid arthritis with and without auto-antibodies against cyclic citrullinated peptides. Arthritis Res Ther. 2006;8:R133

    Google Scholar 

  4. Symmons DP. Environmental factors and the outcome of rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2003;17:717-727.

    Google Scholar 

  5. Liao KP, Alfredsson L, Karlson EW. Environmental influences on risk for Rheumatoid Arthritis. Curr Opin Rheumatol. 2009;21:279-283.

    Google Scholar 

  6. Linn-Rasker SP, van der Helm van Mil AH, et al. Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles. Ann Rheum Dis. 2007;65:366-371

    Google Scholar 

  7. Hart JE, Laden F, Puett RC, Costenbader KH, Karlson EW. Exposure to traffic pollution and increased risk of rheumatoid arthritis. Environ Health Perspect. 2009;117:1065-1069.

    Google Scholar 

  8. Schlesinger N, Schlesinger M. Seasonal variation of rheumatic diseases. Discov Med. 2005;5:64-69

    Google Scholar 

  9. Loyola-Rodriguez JP, Martinez-Martinez RE, Abud-Mendoza C, Patino-Marin N, Seymour GJ, et al. Rheumatoid arthritis and the role of oral bacteria. J Oral Microbiol. 2010;2.

    Google Scholar 

  10. Söderlund M, van Essen R, Haapasaari J, Kiistala U, Kiviluoto O, Hedman K. Persistence of parvovirus B19 DNA in synovial membranes of young patient with and without chronic arthropathy. Lancet. 1997;349:1063-1065.

    Google Scholar 

  11. Klareskog L, Stolt P, Lundberg K, et al. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum. 2006;54:38-46.

    Google Scholar 

  12. Maxwell JR, Gowers IR, Moore DJ, Wilson AG. Alcohol consumption is inversely associated with risk and severity of rheumatoid arthritis. Rheumatology (Oxford). 2010;49:2140-2146.

    Google Scholar 

  13. Pikwer M, Bergström U, Nilsson JA, Jacobsson L, Berglund G, Turesson C. Breast feeding, but not use of oral contraceptives, is associated with a reduced risk of rheumatoid arthritis. Ann Rheum Dis. 2009;68:526-530.

    Google Scholar 

  14. Jorgensen C, Picot MC, Bologna C, Sany J. Oral contraception, parity, breast feeding, and severity of rheumatoid arthritis. Ann Rheum Dis. 1996;55:94-98.

    Google Scholar 

  15. Doran MF, Crowson CS, O’Fallon WM, Gabriel SE. The effect of oral contraceptives and estrogen replacement therapy on the risk of rheumatoid arthritis: a population based study. J Rheumatol. 2004;31:207-213.

    Google Scholar 

  16. Karlson EW, Mandl LA, Hankinson SE, Grodstein F. Do breast-feeding and other reproductive factors influence future risk of rheumatoid arthritis? Results from the Nurses’ Health Study. Arthritis Rheum. 2004;50:3458-3467.

    Google Scholar 

  17. Rantapaa-Dahlqvist S, de Jong BA, Berglin E, et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003;48:2741-2749.

    Google Scholar 

  18. Deane KD, O’Donnell CI, Hueber Wet al. The number of elevated cytokines and chemokines in preclinical seropositive rheumatoid arthritis predicts time to diagnosis in an age-dependent manner. Arthritis Rheum. 2010;62:3161-3172.

    Google Scholar 

  19. Nielen MM, van Schaardenburg D, Reesink HW, et al. Simultaneous development of acute phase response and autoantibodies in preclinical rheumatoid arthritis. Ann Rheum Dis. 2006;65:535-537.

    Google Scholar 

  20. Karlson EW, Chibnik LB, Tworoger SS, et al. Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies. Arthritis Rheum. 2009;60:641-652.

    Google Scholar 

  21. Turesson C, Bergström U, Jacobsson LT, et al. Increased cartilage turnover and circulating autoantibodies in different subsets before the clinical onset of rheumatoid arthritis. Ann Rheum Dis. 2011;70:520-522.

    Google Scholar 

  22. van Schaardenburg D, Nielen MM, Lems WF, et al. Bone metabolism is altered in preclinical rheumatoid arthritis. Ann Rheum Dis. 2011;70:1173-1174.

    Google Scholar 

  23. van de Stadt LA, van Sijl AM, van Schaardenburg D, Nurmohamed MT. Dyslipidaemia in patients with seropositive arthralgia predicts the development of arthritis. Ann Rheum Dis. 2012; 71:1915-1916.

    Google Scholar 

  24. Bos WH, Wolbink GJ, Boers M, et al. Arthritis development in patients with arthralgia is strongly associated with anticitrullinated protein antibody status: a prospective cohort study. Ann Rheum Dis. 2010;69:490-494.

    Google Scholar 

  25. van de Stadt LA, Bos WH, Meursinge Reynders M, et al. The value of ultrasonography in predicting arthritis in auto-antibody positive arthralgia patients: a prospective cohort study. Arthritis Res Ther. 2010;12:R98.

    Google Scholar 

  26. van de Sande MG, de Hair MJ, van der Leij C, et al. Different stages of rheumatoid arthritis: features of the synovium in the preclinical phase. Ann Rheum Dis. 2011;70:772-777.

    Google Scholar 

  27. Kraan MC, Versendaal H, Jonker M, et al. Asymptomatic synovitis precedes clinically manifest arthritis. Arthritis Rheum. 1998;41:1481-1488.

    Google Scholar 

  28. Filer A, de Pablo P, Allen G, et al. Utility of ultrasound joint counts in the prediction of rheumatoid arthritis in patients with very early synovitis. Ann Rheum Dis. 2011;70:500-507.

    Google Scholar 

  29. de Rooy DP, Kälvesten J, Huizinga TW, van der Helm-van Mil AH. Loss of metacarpal bone density predicts RA development in recent-onset arthritis. Rheumatology (Oxford). 2012;51:1037-1041.

    Google Scholar 

  30. Duer-Jensen A, Hørslev-Petersen K, Hetland ML, et al. Bone edema on magnetic resonance imaging is an independent predictor of rheumatoid arthritis development in patients with early undifferentiated arthritis. Arthritis Rheum. 2011;63:2192-2202.

    Google Scholar 

  31. Krabben A, Huizinga TW, van der Helm-van Mil AH. Undifferentiated arthritis characteristics and outcomes when applying the 2010 and 1987 criteria for rheumatoid arthritis. Ann Rheum Dis. 2012;71:238-241.

    Google Scholar 

  32. Haavardsholm EA, Bøyesen P, Østergaard M, Schildvold A, Kvien TK. Magnetic resonance imaging findings in 84 patients with early rheumatoid arthritis: bone marrow oedema predicts erosive progression. Ann Rheum Dis. 2008;67:794-800.

    Google Scholar 

  33. Syversen SW, Goll GL, Haavardsholm EA, Bøyesen P, Lea T, Kvien TK. A high serum level of eotaxin (CCL 11) is associated with less radiographic progression in early rheumatoid arthritis patients. Arthritis Res Ther. 2008;10:R28.

    Google Scholar 

  34. Bøyesen P, Haavardsholm EA, Ostergaard M, van der Heijde D, Sesseng S, Kvien TK. MRI in early rheumatoid arthritis: synovitis and bone marrow oedema are independent predictors of subsequent radiographic progression. Ann Rheum Dis. 2010;70:428-433.

    Google Scholar 

  35. Døhn UM, Ejbjerg B, Boonen A, et al. No overall progression and occasional repair of erosions despite persistent inflammation in adalimumab-treated rheumatoid arthritis patients: results from a longitudinal comparative MRI, ultrasonography, CT and radiography study. Ann Rheum Dis. 2010;70:252-258.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Healthcare

About this chapter

Cite this chapter

van der Helmvan Mil, A.H., Stomp, W., Reijnierse, M., Huizinga, T.W. (2015). Pre-rheumatoid arthritis. In: Emery, P. (eds) Atlas of Rheumatoid Arthritis. Springer Healthcare, Tarporley. https://doi.org/10.1007/978-1-907673-91-7_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-907673-91-7_2

  • Published:

  • Publisher Name: Springer Healthcare, Tarporley

  • Print ISBN: 978-1-907673-90-0

  • Online ISBN: 978-1-907673-91-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics