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Mechanical Factors Affecting the Mobility of Membrane Proteins

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Physics of Biological Membranes

Abstract

The mobility of membrane proteins controls many biological functions. The application of the model of Saffman and Delbrück to the diffusion of membrane proteins does not account for all the experimental measurements. These discrepancies have triggered a lot of studies on the role of the mechanical factors in the mobility. After a short review of the Saffman and Delbrück model and of some key experiments, we explore the various ways to incorporate the effects of the different mechanical factors. Our approach focuses on the coupling of the protein to the membrane, which is the central element in the modeling. We present a general, polaron-like model, its recent application to the mobility of a curvature sensitive protein, and its various extensions to other couplings that may be relevant in future experiments.

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Acknowledgements

We would like to thank P. Quemeneur, J. K. Sigurdsson, M. Renner, P. J. Atzberger, and P. Bassereau for a previous collaboration, which motivated this chapter. In addition, we would like to acknowledge stimulating discussions with W. Urbach and M. S. Turner. D L would also like to thank Labex CelTisPhysBio (N ANR-10-LBX-0038) part of IDEX PSL (NANR-10-IDEX-0001-02 PSL) for financial support.

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Authors and Affiliations

  1. Laboratoire de Physico-Chimie Théorique, UMR CNRS Gulliver 7083, ESPCI, Paris, France

    Vincent Démery & David Lacoste

Authors
  1. Vincent Démery
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  2. David Lacoste
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Correspondence to David Lacoste .

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Editors and Affiliations

  1. PhysicoChimie Curie (UMR CNRS 168), Institut Curie, Paris, France

    Patricia Bassereau

  2. PhysicoChimie Curie (UMR CNRS 168), Institut Curie, Paris, France

    Pierre Sens

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Démery, V., Lacoste, D. (2018). Mechanical Factors Affecting the Mobility of Membrane Proteins. In: Bassereau, P., Sens, P. (eds) Physics of Biological Membranes. Springer, Cham. https://doi.org/10.1007/978-3-030-00630-3_8

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