Skip to main content

Clinical Applications of PET/MRI in Brain Imaging

  • Chapter
  • First Online:
PET/CT in Brain Disorders

Abstract

Brain imaging is one of the valuable applications of the hybrid PET/MRI given the anatomical and physiological complexity of the brain and the subtlety of the neurological changes that accompany many of the neurodegenerative, epileptic, and oncological diseases. The limited resolution of CT in imaging brain makes the MRI the ideal modality for neuroimaging. This resulted in growing interest in the medical, physics, and pharmaceutical communities to develop novel radiopharmaceuticals and apply new MRI sequences for early diagnosis, predicting the behavior and having a better insight of the neurological disorders. This chapter provides a concise overview of the combined PET/MRI clinical uses in neuroimaging of patients with neurodegenerative, epileptic and brain neoplastic diseases. It also compares its advantages and disadvantages to those of other available imaging modalities.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 79.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Fraioli F, Punwani S. Clinical and research applications of simultaneous positron emission tomography and MRI. Br J Radiol. 2014;87(1033):20130464.

    CAS  PubMed  Google Scholar 

  2. Kalemis A, Delattre BMA, Heinzer S. Sequential whole-body PET/MR scanner: concept, clinical use, and optimisation after two years in the clinic. The manufacturer’s perspective. Magn Reson Mater Phys Biol Med. 2013;26(1):5–23.

    CAS  Google Scholar 

  3. Tudisca C, Nasoodi A, Fraioli F. PET-MRI. Nucl Med Commun. 2015;36(7):666–78.

    PubMed  Google Scholar 

  4. Schwenzer NF, et al. Simultaneous PET/MR imaging in a human brain PET/MR system in 50 patients—current state of image quality. Eur J Radiol. 2012;81(11):3472–8.

    CAS  PubMed  Google Scholar 

  5. Hirata Y, et al. Voxel-based morphometry to discriminate early Alzheimer’s disease from controls. Neurosci Lett. 2005;382(3):269–74.

    CAS  PubMed  Google Scholar 

  6. Guo X, et al. Voxel-based assessment of gray and white matter volumes in Alzheimer’s disease. Neurosci Lett. 2010;468(2):146–50.

    CAS  PubMed  Google Scholar 

  7. Goubran M, et al. Assessment of PET & ASL metabolism in the hippocampal subfields of MCI and AD using simultaneous PET-MR. EJNMMI Phys. 2015;2(Suppl 1):A73.

    PubMed  PubMed Central  Google Scholar 

  8. Oishi K, Mielke MM, Albert M, Lyketsos CG, Mori S. DTI analyses and clinical applications in Alzheimer’s disease. J Alzheimers Dis. 2011;26(Suppl 3):287–96.

    PubMed  PubMed Central  Google Scholar 

  9. Prasad G, Nir TM, Toga AW, Thompson PM. Tractography density and network measures in Alzheimer’s disease. In: 2013 IEEE 10th International Symposium on Biomedical Imaging, vol. 2013; 2013. p. 692–5.

    Google Scholar 

  10. Heiss W-D, Raab P, Lanfermann H. Multimodality assessment of brain tumors and tumor recurrence. J Nucl Med. 2011;52(10):1585–600.

    CAS  PubMed  Google Scholar 

  11. Rees JH. Diagnosis and treatment in neuro-oncology: an oncological perspective. Br J Radiol. 2011;84(Spec Iss 2):S82–9.

    PubMed  Google Scholar 

  12. Knopp EA, et al. Glial neoplasms: dynamic contrast-enhanced T2*-weighted MR imaging. Radiology. 1999;211(3):791–8.

    CAS  PubMed  Google Scholar 

  13. Scott JN, Brasher PMA, Sevick RJ, Rewcastle NB, Forsyth PA. How often are nonenhancing supratentorial gliomas malignant? A population study. Neurology. 2002;59(6):947–9.

    CAS  PubMed  Google Scholar 

  14. Bisdas S, et al. Metabolic mapping of gliomas using hybrid MR-PET imaging. Investig Radiol. 2013;48(5):295–301.

    CAS  Google Scholar 

  15. Bisdas S, lá Fougere C, Ernemann U. Hybrid MR-PET in neuroimaging. Clin Neuroradiol. 2015;25:275–81.

    PubMed  Google Scholar 

  16. Halac G, et al. Compatibility of MRI and FDG-PET findings with histopathological results in patients with focal cortical dysplasia. Seizure. 2017;45:80–6.

    PubMed  Google Scholar 

  17. Shin HW, et al. Initial experience in hybrid PET-MRI for evaluation of refractory focal onset epilepsy. Seizure. 2015;31:1–4.

    PubMed  Google Scholar 

  18. Ward BP. Arab Health: is PET/MRI really worth the extra cost? AuntMinnie Europe; 2013. p. 28–29.

    Google Scholar 

  19. Bailey DL, et al. Combined PET/MR: the real work has just started. Summary Report of the Third International Workshop on PET/MR Imaging; February 17–21, 2014, Tübingen, Germany. Mol Imaging Biol. 2015;17(3):297–312.

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Karar Obeed Almansory MBChB, MRCP, MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Fraioli, F., Almansory, K.O. (2019). Clinical Applications of PET/MRI in Brain Imaging. In: Fraioli, F. (eds) PET/CT in Brain Disorders. Clinicians’ Guides to Radionuclide Hybrid Imaging(). Springer, Cham. https://doi.org/10.1007/978-3-030-01523-7_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-01523-7_13

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-01522-0

  • Online ISBN: 978-3-030-01523-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics