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Heat Shock Response and Metabolism in Skeletal Muscle

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Heat Shock Proteins in Signaling Pathways

Part of the book series: Heat Shock Proteins ((HESP,volume 17))

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Abstract

Skeletal muscle comprises approximately 40% of the total body mass in humans. It plays important roles in locomotion, metabolism and endocrine signaling. We and others have previously described the biological responses/adaptations of skeletal muscle to heat stress, the contributions of heat shock proteins to the cellular processes underlying the muscle response to heat stress, and the therapeutic potential of manipulating heat stress and heat shock proteins in skeletal muscle. In this chapter, I briefly summarize current understanding of the heat stress-induced regulation of protein, glucose and mitochondrial metabolism in skeletal muscle. Furthermore, I overview future perspectives on studies of the heat shock response in skeletal muscle biology.

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Abbreviations

AMPK:

AMP-activated protein kinase

BGP-15:

O-[3-piperidino-2-hydroxy-1-propyl]-nicotinic amidoxime

CaMKII:

Ca2+/calmodulin-dependent protein kinase II

DEPTORDEP:

domain-containing mTOR-interacting protein

FOXO:

forkhead box O

GLUT:

glucose transporter

HSE:

heat shock element

HSF1:

heat shock factor 1

HSP:

heat shock protein

IGF-1:

insulin-like growth factor 1

JNK:

c-Jun N-terminal kinases

LC3:

microtubule-associated proteins 1A/1B light chain 3

MAPK:

mitogen-activated protein kinase

MFN2:

mitofusion 2

MLST8:

MTOR associated protein

mTOR:

mechanistic target of rapamycin

NRF:

nuclear respiratory factor

PGC-1α:

peroxisome proliferator-activated receptor gamma coactivator 1-alpha

PP2A:

protein phosphatase 2

PPAR:

peroxisome proliferator-activated receptor

PRAS:

proline-rich Akt substrate

RAPTOR:

regulatory-associated protein

ROS:

reactive oxygen species

UPR:

unfolded protein response

VDAC:

voltage-dependent anion channels

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Acknowledgements

Yuki Tamura is the recipient of a post-doctoral fellowship from the Japan Society for the Promotion of Science, Tokyo, Japan.

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Authors and Affiliations

  1. Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan

    Yuki Tamura

  2. Faculty of Sport Science, Nippon Sport Science University, Tokyo, Japan

    Yuki Tamura

  3. Center for Coaching Excellence, Nippon Sport Science University, Tokyo, Japan

    Yuki Tamura

  4. Research Institute for Sport Science, Nippon Sport Science University, Tokyo, Japan

    Yuki Tamura

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  1. Yuki Tamura
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Correspondence to Yuki Tamura .

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Editors and Affiliations

  1. Professor, Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center Eleanor N. Dana Cancer Center, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Tamura, Y. (2019). Heat Shock Response and Metabolism in Skeletal Muscle. In: Asea, A., Kaur, P. (eds) Heat Shock Proteins in Signaling Pathways. Heat Shock Proteins, vol 17. Springer, Cham. https://doi.org/10.1007/978-3-030-03952-3_3

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