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Medication Strategies: Switching, Tapering, Cross-Over, Overmedication, Drug-Drug Interactions, and Discontinuation Syndromes

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Abstract

Psychotropic medications are known to cause a heightened risk of significant adverse effects in the geriatric population, including falls, hip fractures, delirium, and over-sedation. Geriatric patients may experience these and other adverse effects due to altered pharmacokinetics and pharmacodynamics, which must be considered when prescribing or changing regimens. The aged are also more likely to be prescribed multiple medications due to concurrent illnesses, with a higher risk of medication-related problems. Strategies are offered for switching, tapering, and cross-tapering of psychotropics to enhance efficacy and to minimize discontinuation syndromes and other adverse effects.

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References

  1. Kaufman DW, Kelly JP, Rosenberg L, Anderson TE, Mitchell AA. Recent patterns of medication use in the ambulatory adult population of the United States. The Slone survey. JAMA. 2002;287:337–44.

    Article  Google Scholar 

  2. Budnitz DS, Lovegrove MC, Shehab N, Richards CL. Emergency hospitalization for adverse drug events in older Americans. NEJM. 2011;365(21):2002–12.

    Article  CAS  Google Scholar 

  3. Masoon N, Shakib S, Kalisch L, Caughey G. Systemic review of polypharmacy definition, assessment tools, and association with clinical outcomes. Res Social Adm Pharm. 2017;13(4):E28–29.4.

    Article  Google Scholar 

  4. American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American geriatrics society 2015 updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2015;63:2227–46.

    Article  Google Scholar 

  5. Correll CU. Switching and combining antipsychotics. CNS Spectrums. 2010;15(56):8–11.

    Article  Google Scholar 

  6. DSM-5. American Psychiatric Association. DSM-5 Arlington (Va): APA, 2013.

    Google Scholar 

  7. Bhat V, Kenndey S. Recognition and management of antidepressant discontinuation syndrome. J Psychiatry Neurosci. 2017;42(4):E7–8.

    Article  Google Scholar 

  8. Fava GA, Gatti A, Belaise C, et al. Withdrawal symptoms after selective serotonin reuptake inhibitor discontinuation: a systematic review. Psychother Psychosom. 2015;84:72–81.

    Article  Google Scholar 

  9. Keks N, Hope J, Keogh S. Switching and stopping antidepressants. Aust Prescr. 2016;39:76–83.

    PubMed  PubMed Central  Google Scholar 

  10. Wilson E, Lader M. A review of the management of antidepressant discontinuation symptoms. Ther Adv Psychopharmacol. 2015;5(6):357–68.

    Article  CAS  Google Scholar 

  11. Takeuchi H, Kantor N, Uchida H, Suzuki T, Remington G. Immediate vs. gradual discontinuation in antipsychotic switch: a systematic review and meta-analysis. Schizoph Bull. 2017;43(4):862–71.

    PubMed  Google Scholar 

  12. Olfson M, King M, Schoenbaum M. Benzodiazepine use in the united states. JAMA Psychiatry. 2015;72(2):136–42.

    Article  Google Scholar 

  13. Cunningham CM, Hanely GE, Morgan S. Patterns of use of benzodiazepines in British Columbia: examining the impact of increasing research and guideline cautions against long-term use. Health Policy. 2010;97:122–9.

    Article  Google Scholar 

  14. National Institute of Health. Despite risks, Benzodiazepine use highest in older people. December 2014. Available from https://www.nimh.nih.gov/news/science-news/2014/despite-risks-benzodiazepine-use-highest-in-older-people.shtml.

  15. Brett J, Murnion B. Management of benzodiazepine misuse and dependence. Aust Prescriber. 2015;38(5):152–5.

    Article  Google Scholar 

  16. Gould RL, Coulson MC, Howard RJ. Cognitive behavioral therapy for depression in older people: a meta-analysis and meta-regression of randomized controlled trials. J Am Geriatr Soc. 2012;60(10):1817–30.

    Article  Google Scholar 

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Correspondence to Timothy Lau .

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Kozyra, E., Lau, T. (2019). Medication Strategies: Switching, Tapering, Cross-Over, Overmedication, Drug-Drug Interactions, and Discontinuation Syndromes. In: Fenn, H., Hategan, A., Bourgeois, J. (eds) Inpatient Geriatric Psychiatry . Springer, Cham. https://doi.org/10.1007/978-3-030-10401-6_17

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  • DOI: https://doi.org/10.1007/978-3-030-10401-6_17

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-10400-9

  • Online ISBN: 978-3-030-10401-6

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