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Biomimetic Model Membranes as Drug Screening Platform

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Biomimetic Lipid Membranes: Fundamentals, Applications, and Commercialization

Abstract

Biomimetic model membranes were inspired by natural cell membrane and are rapidly progressing in the field for varied applications, especially for drug screening studies. Biomimetic lipid membranes such as lipid monolayer, lipid vesicles, and supported lipid membranes have been constructed to investigate the cell membrane and membrane protein interaction with various drugs. Also, biomimetic lipid membranes provide an experimental platform to understand disease at the molecular level, which is also an important step for developing new therapeutic agents. This chapter covers biomimetic model membrane types utilized to screen drug–membrane and drug–receptor interactions, characterization techniques, and an overview of recent work in the field.

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Authors and Affiliations

  1. Department of Bioengineering, Izmir Institute of Technology, Urla, Izmir, Turkey

    Rumeysa Bilginer & Ahu Arslan Yildiz

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  1. Rumeysa Bilginer
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  2. Ahu Arslan Yildiz
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Correspondence to Ahu Arslan Yildiz .

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Editors and Affiliations

  1. Department of Molecular Biology and Genetics, İstanbul Technical University, Istanbul, Turkey

    Fatma N. Kök

  2. Department of Bioengineering, Izmir Institute of Technology, Urla, Izmir, Turkey

    Ahu Arslan Yildiz

  3. School of Medicine, Stanford University, Palo Alto, CA, USA

    Fatih Inci

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Bilginer, R., Arslan Yildiz, A. (2019). Biomimetic Model Membranes as Drug Screening Platform. In: Kök, F., Arslan Yildiz, A., Inci, F. (eds) Biomimetic Lipid Membranes: Fundamentals, Applications, and Commercialization. Springer, Cham. https://doi.org/10.1007/978-3-030-11596-8_10

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