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Orbital Rhabdomyosarcoma

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Clinical Ophthalmic Oncology

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Abstract

Rhabdomyosarcoma (RMS) represents the most common orbital malignancy in children; patients with this disease often present to the ophthalmologist. Because current therapeutic regimens offer an excellent chance for curing isolated orbital disease, prompt diagnosis and treatment are essential. Four decades ago, the standard of care for these tumors was exenteration. Even with exenteration, survival was poor. Much of the success in reducing the morbidity and mortality over the past three decades has been through the collaborative efforts of the Intergroup Rhabdomyosarcoma Studies (IRS) formulated in the 1970s. Treatment of RMS with multiple modalities has transformed the dismal 25% 3-year life expectancy of the 1960s to overall survival (OS) rates of higher than 90% today. With such success, clinicians now have the opportunity to focus on minimizing the serious late sequelae of aggressive therapy.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology and Oculofacial Plastic Surgery, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA

    Julian D. Perry

  2. Division of Facial Cosmetic and Reconstructive Surgery, University of Utah, Salt Lake City, UT, USA

    Bhupendra C. K. Patel

Authors
  1. Julian D. Perry
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  2. Bhupendra C. K. Patel
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Corresponding author

Correspondence to Bhupendra C. K. Patel .

Editor information

Editors and Affiliations

  1. Division of Orbital and Oculofacial Plastic Surgery, Cole Eye Institute Cleveland Clinic Foundation, Cleveland, OH, USA

    Catherine J. Hwang

  2. Division of Facial Cosmetic and Reconstructive Surgery, University of Utah, Salt Lake City, UT, USA

    Bhupendra C.K. Patel

  3. Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland, OH, USA

    Arun D. Singh

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Perry, J.D., Patel, B.C.K. (2019). Orbital Rhabdomyosarcoma. In: Hwang, C.J., Patel, B.C., Singh, A.D. (eds) Clinical Ophthalmic Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-13558-4_17

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  • DOI: https://doi.org/10.1007/978-3-030-13558-4_17

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-13557-7

  • Online ISBN: 978-3-030-13558-4

  • eBook Packages: MedicineMedicine (R0)

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