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2D-Based Coarse-to-Fine Approaches for Small Target Segmentation in Abdominal CT Scans

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Deep Learning and Convolutional Neural Networks for Medical Imaging and Clinical Informatics

Abstract

Deep neural networks have been widely adopted for automatic organ segmentation from abdominal CT scans. However, the segmentation accuracy of small organs (e.g., pancreas) or neoplasms (e.g., pancreatic cyst) is sometimes below satisfaction, arguably because deep networks are easily disrupted by the complex and variable background regions which occupy a large fraction of the input volume. In this chapter, we propose two coarse-to-fine mechanisms which use prediction from the first (coarse) stage to shrink the input region for the second (fine) stage. More specifically, the two stages in the first method are trained individually in a step-wise manner, so that the entire input region and the region cropped according to the bounding box are treated separately. While the second method inserts a saliency transformation module between the two stages so that the segmentation probability map from the previous iteration can be repeatedly converted as spatial weights to the current iteration. In training, it allows joint optimization over the deep networks. In testing, it propagates multi-stage visual information throughout iterations to improve segmentation accuracy. Experiments are performed on several CT datasets, including NIH pancreas, JHMI multi-organ, and JHMI pancreatic cyst dataset. Our proposed approach gives strong results in terms of DSC.

Y. Zhou and Q. Yu contributed equally to this work.

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Notes

  1. 1.

    Please see Sect. 3.5.3.2 for the comparison to 3D networks.

References

  1. Ali A, Farag A, El-Baz A (2007) Graph cuts framework for kidney segmentation with prior shape constraints. In: International conference on medical image computing and computer-assisted intervention

    Google Scholar 

  2. Brosch T, Tang L, Yoo Y, Li D, Traboulsee A, Tam R (2016) Deep 3D convolutional encoder networks with shortcuts for multiscale feature integration applied to multiple Sclerosis Lesion segmentation. IEEE Trans Med Imaging 35(5):1229–1239

    Article  Google Scholar 

  3. Cai J, Lu L, Xie Y, Xing F, Yang L (2017) Improving deep pancreas segmentation in CT and MRI images via recurrent neural contextual learning and direct loss function. In: International conference on medical image computing and computer-assisted intervention

    Google Scholar 

  4. Chen H, Dou Q, Wang X, Qin J, Heng P (2016) Mitosis detection in breast cancer histology images via deep Cascaded networks. In: AAAI conference on artificial intelligence

    Google Scholar 

  5. Chen L, Papandreou G, Kokkinos I, Murphy K, Yuille A (2015) Semantic image segmentation with deep convolutional nets and fully connected CRFs. In: International conference on learning representations

    Google Scholar 

  6. Chu C, Oda M, Kitasaka T, Misawa K, Fujiwara M, Hayashi Y, Nimura Y, Rueckert D, Mori K (2013) Multi-organ segmentation based on spatially-divided probabilistic Atlas from 3D abdominal CT images. In: International conference on medical image computing and computer-assisted intervention

    Google Scholar 

  7. Dmitriev K, Gutenko I, Nadeem S, Kaufman A (2016) Pancreas and cyst segmentation. In: Medical imaging 2016: image processing, vol 9784, pp 97842C

    Google Scholar 

  8. Dou Q, Chen H, Jin Y, Yu L, Qin J, Heng P (2016) 3D deeply supervised network for automatic liver segmentation from CT volumes. In: International conference on medical image computing and computer-assisted intervention

    Google Scholar 

  9. Everingham M, Van Gool L, Williams C, Winn J, Zisserman A (2010) The Pascal visual object classes (VOC) challenge. Int J Comput Vis 88(2):303–338

    Article  Google Scholar 

  10. Girshick R, Donahue J, Darrell T, Malik J (2014) Rich feature hierarchies for accurate object detection and semantic segmentation. In: Computer vision and pattern recognition

    Google Scholar 

  11. Graves A, Mohamed A, Hinton G (2013) Speech recognition with deep recurrent neural networks. In: International conference on acoustics, speech and signal processing

    Google Scholar 

  12. Harrison A, Xu Z, George K, Lu L, Summers R, Mollura D (2017) Progressive and multi-path holistically nested neural networks for pathological lung segmentation from CT images. In: International conference on medical image computing and computer-assisted intervention

    Google Scholar 

  13. Havaei M, Davy A, Warde-Farley D, Biard A, Courville A, Bengio Y, Pal C, Jodoin P, Larochelle H (2017) Brain tumor segmentation with deep neural networks. In: Medical image analysis

    Google Scholar 

  14. He K, Zhang X, Ren S, Sun J (2016) Deep residual learning for image recognition. In: Computer vision and pattern recognition

    Google Scholar 

  15. Heimann T, Van Ginneken B, Styner M, Arzhaeva Y, Aurich V, Bauer C, Beck A, Becker C, Beichel R, Bekes G et al (2009) Comparison and evaluation of methods for liver segmentation from CT datasets. IEEE Trans Med Imaging 28(8):1251–1265

    Article  Google Scholar 

  16. Hu S, Hoffman E, Reinhardt J (2001) Automatic lung segmentation for accurate quantitation of volumetric X-ray CT images. IEEE Trans Med Imaging 20(6):490–498

    Article  Google Scholar 

  17. Kamnitsas K, Ledig C, Newcombe V, Simpson J, Kane A, Menon D, Rueckert D, Glocker B (2017) Efficient multi-scale 3D CNN with fully connected CRF for accurate brain lesion segmentation. Med Image Anal 36:61–78

    Article  Google Scholar 

  18. Krizhevsky A, Sutskever I, Hinton G (2012) ImageNet classification with deep convolutional neural networks. In: Advances in neural information processing systems

    Google Scholar 

  19. Kuen J, Wang Z, Wang G (2016) Recurrent attentional networks for saliency detection. In: Computer vision and pattern recognition

    Google Scholar 

  20. Lai M (2015) Deep learning for medical image segmentation. arXiv:1505.02000

  21. Lee C, Xie S, Gallagher P, Zhang Z, Tu Z (2015) Deeply-supervised nets. In: International conference on artificial intelligence and statistics

    Google Scholar 

  22. Li G, Xie Y, Lin L, Yu Y (2017) Instance-level salient object segmentation. In: Computer vision and pattern recognition

    Google Scholar 

  23. Li Q, Wang J, Wipf D, Tu Z (2013) Fixed-point model for structured labeling. In: International conference on machine learning

    Google Scholar 

  24. Liang M, Hu X (2015) Recurrent convolutional neural network for object recognition. In: Computer vision and pattern recognition

    Google Scholar 

  25. Lin D, Lei C, Hung S (2006) Computer-aided kidney segmentation on abdominal CT images. IEEE Trans Inf Technol Biomed 10(1):59–65

    Article  Google Scholar 

  26. Lin G, Milan A, Shen C, Reid I (2017) RefineNet: multi-path refinement networks with identity mappings for high-resolution semantic segmentation. In: Computer vision and pattern recognition

    Google Scholar 

  27. Ling H, Zhou S, Zheng Y, Georgescu B, Suehling M, Comaniciu D (2008) Hierarchical, learning-based automatic liver segmentation. In: Computer vision and pattern recognition

    Google Scholar 

  28. Linguraru M, Sandberg J, Li Z, Shah F, Summers R (2010) Automated segmentation and quantification of liver and spleen from CT images using normalized probabilistic Atlases and enhancement estimation. Med Phys 37(2):771–783

    Article  Google Scholar 

  29. Long J, Shelhamer E, Darrell T (2015) Fully convolutional networks for semantic segmentation. In: Computer vision and pattern recognition

    Google Scholar 

  30. Merkow J, Kriegman D, Marsden A, Tu Z (2016) Dense volume-to-volume vascular boundary detection. In: International conference on medical image computing and computer-assisted intervention

    Google Scholar 

  31. Milletari F, Navab N, Ahmadi S (2016) V-Net: fully convolutional neural networks for volumetric medical image segmentation. In: International conference on 3d vision

    Google Scholar 

  32. Pinheiro P, Collobert R (2014) Recurrent convolutional neural networks for scene labeling. In: International conference on machine learning

    Google Scholar 

  33. Ren S, He K, Girshick R, Sun J (2015) Faster R-CNN: towards real-time object detection with region proposal networks. In: Advances in neural information processing systems

    Google Scholar 

  34. Ronneberger O, Fischer P, Brox T (2015) U-Net: convolutional networks for biomedical image segmentation. In: International conference on medical image computing and computer-assisted intervention

    Google Scholar 

  35. Roth H, Lu L, Farag A, Shin H, Liu J, Turkbey E, Summers R (2015) DeepOrgan: multi-level deep convolutional networks for automated pancreas segmentation. In: International conference on medical image computing and computer-assisted intervention

    Google Scholar 

  36. Roth H, Lu L, Farag A, Sohn A, Summers R (2016) Spatial aggregation of holistically-nested networks for automated pancreas segmentation. In: International conference on medical image computing and computer-assisted intervention

    Google Scholar 

  37. Roth H, Lu L, Lay N, Harrison A, Farag A, Sohn A, Summers R (2017) Spatial aggregation of holistically-nested convolutional neural networks for automated pancreas localization and segmentation. arXiv:1702.00045

  38. Shen W, Wang B, Jiang Y, Wang Y, Yuille A (2017) Multi-stage multi-recursive-input fully convolutional networks for neuronal boundary detection. In: International Conference on Computer Vision

    Google Scholar 

  39. Simonyan K, Zisserman A (2015) Very deep convolutional networks for large-scale image recognition. In: International conference on learning representations

    Google Scholar 

  40. Socher R, Lin C, Manning C, Ng A (2011) Parsing natural scenes and natural language with recursive neural networks. In: International conference on machine learning

    Google Scholar 

  41. Tang P, Wang X, Bai S, Shen W, Bai X, Liu W, Yuille AL (2018) PCL: proposal cluster learning for weakly supervised object detection. In: IEEE transaction on pattern analysis and machine intelligence

    Google Scholar 

  42. Wang D, Khosla A, Gargeya R, Irshad H, Beck A (2016) Deep learning for identifying metastatic breast cancer. arXiv:1606.05718

  43. Wang Y, Zhou Y, Tang P, Shen W, Fishman EK, Yuille AL (2018) Training multi-organ segmentation networks with sample selection by relaxed upper confident bound. In: International conference on medical image computing and computer-assisted intervention

    Google Scholar 

  44. Wang Y, Zhou Y, Shen W, Park S, Fishman EK, Yuille AL (2018) Spatial aggregation of holistically-nested convolutional neural networks for automated pancreas localization and segmentation. arXiv:1804.08414

  45. Wang Z, Bhatia K, Glocker B, Marvao A, Dawes T, Misawa K, Mori K, Rueckert D (2014) Geodesic patch-based segmentation. In: International conference on medical image computing and computer-assisted intervention

    Google Scholar 

  46. Xia F, Wang P, Chen L, Yuille A (2016) Zoom better to see clearer: human and object parsing with hierarchical auto-zoom net. In: European Conference on Computer Vision

    Google Scholar 

  47. Yu L, Yang X, Chen H, Qin J, Heng P (2017) Volumetric ConvNets with mixed residual connections for automated prostate segmentation from 3D MR images. In: AAAI Conference on Artificial Intelligence

    Google Scholar 

  48. Yu Q, Xie L, Wang Y, Zhou Y, Fishman E, Yuille A (2018) Recurrent saliency transformation network: incorporating multi-stage visual cues for small organ segmentation. In: Computer vision and patter recognition

    Google Scholar 

  49. Zhang L, Lu L, Summers RM, Kebebew E, Yao J (2017) Personalized pancreatic tumor growth prediction via group learning. In: International conference on medical image computing and computer-assisted intervention

    Google Scholar 

  50. Zhang Y, Ying M, Yang L, Ahuja A, Chen D (2016) Coarse-to-Fine stacked fully convolutional nets for lymph node segmentation in ultrasound images. In: IEEE international conference on bioinformatics and biomedicine

    Google Scholar 

  51. Zhou Y, Wang Y, Tang P, Bai S, Shen W, Fishman EK, Yuille AL (2019) Semi-supervised multi-organ segmentation via multi-planar co-training. In: IEEE winter conference on applications of computer vision

    Google Scholar 

  52. Zhou Y, Xie L, Fishman E, Yuille A (2017) Deep supervision for pancreatic cyst segmentation in abdominal CT scans. In: International conference on medical image computing and computer-assisted intervention

    Google Scholar 

  53. Zhou Y, Xie L, Shen W, Wang Y, Fishman E, Yuille A (2017) A fixed-point model for pancreas segmentation in abdominal CT scans. In: International conference on medical image computing and computer-assisted intervention

    Google Scholar 

  54. Zhu Z, Xie L, Yuille A (2017) Object recognition with and without objects. In: International joint conference on artificial intelligence

    Google Scholar 

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Correspondence to Alan L. Yuille .

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Zhou, Y. et al. (2019). 2D-Based Coarse-to-Fine Approaches for Small Target Segmentation in Abdominal CT Scans. In: Lu, L., Wang, X., Carneiro, G., Yang, L. (eds) Deep Learning and Convolutional Neural Networks for Medical Imaging and Clinical Informatics. Advances in Computer Vision and Pattern Recognition. Springer, Cham. https://doi.org/10.1007/978-3-030-13969-8_3

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  • DOI: https://doi.org/10.1007/978-3-030-13969-8_3

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