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Asymmetric Dimethylation on Arginine (ADMA) of Histones in Development, Differentiation and Disease

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The DNA, RNA, and Histone Methylomes

Part of the book series: RNA Technologies ((RNATECHN))

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Abstract

Among myriads of histone modifications known today, asymmetric dimethylation of arginines (ADMA) have been found to have important implications in transcriptional regulation of gene expression. These modifications influence organismal development, regulate cellular differentiation of multiple lineages and modulate pathogenesis of various disease forms such as cancer, metabolic disorders and drug addiction. In this chapter, we discuss roles of ADMA of histones mediated by different type I PRMTs in above mentioned physiological contexts and shed light on prospective therapeutic developments.

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Abbreviations

ADMA:

Asymmetric dimethyl arginine

AMI:

Arginine methyltransferase inhibitor

AML:

Acute Myeloblastic Leukemia

AR:

Androgen receptor

BRG1:

Brahma-related gene-1

CaMKII:

Ca2+/calmodulin-dependent protein kinase II

CNC:

Cranial neural crest

CVD:

Cardiovascular diseases

DDAH:

Dimethylarginine dimethylaminohydrolase

DM1:

Type I Diabetes mellitus

E2:

Estradiol

EGFR:

Epidermal growth factor receptor

ER:

Estrogen receptor

GST-P:

Glutathione S-transferase placental form

HCC:

Hepatocellular carcinoma

MEF:

Mouse embryonic fibroblast

MEF2C:

Myocyte enhancer factor-2C

MMA:

Monomethyl arginine

MTA:

Methylthioadenosine

NAc:

Nucleus accumbens

NOS:

Nitric oxide synthase

Nrf2:

Nuclear factor erythroid 2-related factor 2

NS/PC:

Neural stem/precursor cells

OIS:

Oncogene induced senescence

PAD4:

Protein arginine deiminase 4

PAF1c:

Polymerase-Associated Factor 1 complex

PPAR-gamma:

Peroxisome proliferator activated receptor-gamma

PRMT:

Protein arginine methyltransferase

PSA:

Prostate specific antigen

SAM:

S-Adenosyl-l-Methionine

SDMA:

Symmetric dimethylarginine

SRC:

Steroid receptor coactivator

YY1:

Ying Yang 1

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Acknowledgement

TKK is recipient of JC Bose fellowship from Dept. of Science and technology, Govt. of India (SR/S2/JCB-28/2010). This work was supported by funding from Dept. of Biotechnology, Govt. of India (BT/01/CEIB/10/III/01) and JNCASR, India.

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Authors and Affiliations

  1. Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India

    Amit K. Behera & Tapas K. Kundu

  2. CSIR-Central Drug Research Institute, Lucknow, India

    Tapas K. Kundu

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  1. Amit K. Behera
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Correspondence to Tapas K. Kundu .

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  1. Nanobiomedical Center, Adam Mickiewicz University, Poznań, Poland

    Stefan Jurga

  2. Nanobiomedical Center, Adam Mickiewicz University, Poznań, Poland

    Jan Barciszewski

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Behera, A.K., Kundu, T.K. (2019). Asymmetric Dimethylation on Arginine (ADMA) of Histones in Development, Differentiation and Disease. In: Jurga, S., Barciszewski, J. (eds) The DNA, RNA, and Histone Methylomes. RNA Technologies. Springer, Cham. https://doi.org/10.1007/978-3-030-14792-1_20

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