Abstract
Chronic non-cancer pain afflicts approximately 20% of the adult population worldwide representing the most frequent distress faced by physicians of all disciplines [1]. One-third of the patients with chronic pain are in severe pain, and approximately half of them have constant pain leading to diminished quality of life [2].
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References
Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain. 2006;10(4):287–333.
Turner JA, Franklin G, Heagerty PJ, et al. The association between pain and disability. Pain. 2004;112(3):307–14.
Bartley EJ, Fillingim RB. Sex differences in pain: a brief review of clinical and experimental findings. Br J Anaesth. 2013;111(1):52–8.
Berkley KJ. Sex differences in pain. Behav Brain Sci. 1997;20(3):371–80.
Fillingim RB, King CD, Ribeiro-Dasilva MC, Rahim-Williams B, Riley JL III. Sex, gender, and pain: a review of recent clinical and experimental findings. J Pain. 2009;10:447–85.
Gerdle B, Bjork J, Coster L, Henriksson K, Henriksson C, Bengtsson A. Prevalence of widespread pain and associations with work status: a population study. BMC Musculoskelet Disord. 2008;9:102.
Pieretti S, Di Giannuario A, Di Giovannandrea R, Marzoli F, Piccaro G, Minosi P, et al. Gender differences in pain and its relief. Ann Ist Super Sanit. 2016;52(2):184–9.
Mogil JS. Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon. Nat Rev Neurosci. 2012;13:859–66.
Meriggiola MC, Nanni M, Bachiocco V, Vodo S, Aloisi AM. Menopause affects pain depending on pain type and characteristics. Menopause. 2012;19(5):517–23.
Foreman J. Why millions of women are living in chronic pain. WSJ. 2014.
Fillingim RB, Doleys DM, Edwards RR, Lowery D. Clinical characteristics of chronic back pain as a function of gender and oral opioid use. Spine. 2003;28:143–50.
Keefe FJ, Lefebvre JC, Egert JR, Affleck G, Sullivan MJ, Caldwell DS. The relationship of gender to pain, pain behavior, and disability in osteoarthritis patients: the role of catastrophizing. Pain. 2000;87:325–34.
Barnabe C, Bessette L, Flanagan C, et al. Sex differences in pain scores and localization in inflammatory arthritis: a systematic review and metaanalysis. J Rheumatol. 2012;39:1221–30.
Tang YR, Yang WW, Wang YL, Lin L. Sex differences in the symptoms and psychological factors that influence quality of life in patients with irritable bowel syndrome. Eur J Gastroenterol Hepatol. 2012;24:702–7.
Edwards RR, Augustson E, Fillingim RB. Differential relationships between anxiety and treatment-associated pain reduction among male and female chronic pain patients. Clin J Pain. 2003;19:208–16.
Robinson ME, Wise EA, Riley JLI. Sex differences in clinical pain: a multi-sample study. J Clin Psychol Med Settings. 1998;5:413–23.
Turk DC, Okifuji A. Does sex make a difference in the prescription of treatments and the adaptation to chronic pain by cancer and non-cancer patients? Pain. 1999;82:139–48.
Paller CJ, Campbell CM, Edwards RR, Dobs AS. Sex-based differences in pain perception and treatment. Pain Med. 2009;10:289–99.
Fillingim RB, Maixner W. Gender differences in the responses to noxious stimuli. Pain Forum. 1995;4:209–21.
Popescu A, LeResche L, Truelove EL, Drangsholt MT. Gender differences in pain modulation by diffuse noxious inhibitory controls: a systematic review. Pain. 2010;150:309–18.
Edwards RR, Sarlani E, Wesselmann U, Fillingim RB. Quantitative assessment of experimental pain perception: multiple domains of clinical relevance. Pain. 2005;114(3):315–9.
Holdcroft A, Berkley KJ. Sex and gender differences in pain and its relief. In: McMahon SB, Koltzenburg M, editors. Wall and Melzack’s textbook of pain. Philadelphia, PA: Elsevier; 2006.
Miaskowski C, Gear RW, Levine JD. Sex-related differences in analgesic responses. In: Fillingim RB, editor. Sex, gender, and pain. Seattle, WA: IASP Press; 2000. p. 209–30.
Chang K-Y, Tsou M-Y, Chan K-H, Sung C-S, Chang W-K. Factors affecting patient-controlled analgesia requirements. J Formos Med Assoc. 2006;105:918–25.
Fillingim RB, Ness TJ, Glover TL, et al. Morphine responses and experimental pain: sex differences in side effects and cardiovascular responses but not analgesia. J Pain. 2005;6:116–24.
Niesters M, Dahan A, Kest B, et al. Do sex differences exist in opioid analgesia? A systematic review and metaanalysis of human experimental and clinical studies. Pain. 2010;151:61–8.
Calderone KL. The influence of gender on the frequency of pain and sedative medication administered to postoperative patients. Sex Roles. 1990;23:713–25.
Leresche L. Defining gender disparities in pain management. Clin Orthop Relat Res. 2011;469:1871–7.
Craft RM. Modulation of pain by estrogens. Pain. 2007;132:S3–S12.
Craft RM, Mogil JS, Aloisi AM. Sex differences in pain and analgesia: the role of gonadal hormones. Eur J Pain. 2004;8:397.
Smith YR, Stohler CS, Nichols TE, Bueller JA, Koeppe RA, Zubieta JK. Pronociceptive and antinociceptive effects of estradiol through endogenous opioid neurotransmission in women. J Neurosci. 2006;26:5777–85.
Cairns BE, Gazerani P. Sex-related differences in pain. Maturitas. 2009;63:292–6.
Vacca V, Marinelli S, Pieroni L, Urbani A, Luvisetto S, Pavone F. 17beta-estradiol counteracts neuropathic pain: a behavioural, immunohistochemical, and proteomic investigation on sex-related differences in mice. Sci Rep. 2016;6:18980.
LeResche L, Saunders K, Von Korff MR, Barlow W. Use of exogenous hormones and risk of temporomandibular disorder pain. Pain. 1997;69:153.
Tedford WH, Warren DE, Flynn WE. Alteration of shock aversion thresholds during the menstrual cycle. Percept Psychophys. 1977;21:193–6.
Goolkasian P. Cyclic changes in pain perception: an ROC analysis. Percept Psychophys. 1980;27:499.
Dao TT, Knight K, Ton-That V. Modulation of myofascial pain by the reproductive hormones: a preliminary report. J Prosthet Dent. 1998;79:663–70.
Hapidou EG, Rollman GB. Menstrual cycle modulation of tender points. Pain. 1998;77:151.
Vincent K, Warnaby C, Stagg CJ, Moore J, Kennedy S, Tracey I. Brain imaging reveals that engagement of descending inhibitory pain pathways in healthy women in a low endogenous estradiol state varies with testosterone. Pain. 2013;154(4):515–24.
Fillingim RB, Edwards RR, Powell T. Sex-dependent effects of reported familial pain history on recent pain complaints and experimental pain responses. Pain. 2000;86:87–94.
Fillingim RB, Kaplan L, Staud R, et al. The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. J Pain. 2005;6:159–67.
Olsen MB, Jacobsen LM, Schistad EI, et al. Pain intensity the first year after lumbar disc herniation is associated with the A118G polymorphism in the opioid receptor mu 1 gene: evidence of a sex and genotype interaction. J Neurosci. 2012;32:9831–4.
Unruh AM, Ritchie J, Merskey H. Does gender affect appraisal of pain and pain coping strategies? Clin J Pain. 1999;15:31–40.
Keogh E, Eccleston C. Sex differences in adolescent chronic pain and pain-related coping. Pain. 2006;123:275–84.
Sullivan MJ, Thorn B, Haythornthwaite JA, et al. Theoretical perspectives on the relation between catastrophizing and pain. Clin J Pain. 2001;17:52–64.
Bandura A. Self-efficacy: toward a unifying theory of behavioral change. Psychol Rev. 1977;84:191–215.
Keefe FJ, Brown GK, Wallston KA, Caldwell DS. Coping with rheumatoid arthritis pain: catastrophizing as a maladaptive strategy. Pain. 1989;37:51–6.
Somers TJ, Kurakula PC, Criscione-Schreiber L, Keefe FJ, Clowse MEB. Self-efficacy and pain catastrophizing in systemic lupus erythematosus: relationship to pain, stiffness, fatigue, and psychological distress. Arthritis Care Res. 2012;64:1334–40.
Jackson T, Iezzi T, Gunderson J, Nagasaka T, Fritch A. Gender differences in pain perception: the mediating role of self-efficacy beliefs. Sex Roles. 2002;47:561–8.
Robinson ME, Riley JL III, Myers CD, et al. Gender role expectations of pain: relationship to sex differences in pain. J Pain. 2001;2:251–7.
Fillingim RB, Browning AD, Powell T, Wright RA. Sex differences in perceptual and cardiovascular responses to pain: the influence of a perceived ability manipulation. J Pain. 2002;3:439–45.
Robinson ME, Gagnon CM, Riley JL III, Price DD. Altering gender role expectations: effects on pain tolerance, pain threshold, and pain ratings. J Pain. 2003;4:284–8.
Fowler SL, Rasinski HM, Geers AL, Helfer SG, France CR. Concept priming and pain: an experimental approach to understanding gender roles in sex-related pain differences. J Behav Med. 2011;34:139–47.
Defrin R, Shramm L, Eli I. Gender role expectations of pain is associated with pain tolerance limit but not with pain threshold. Pain. 2009;145:230–6.
Walsh CA, Jamieson E, MacMillan H, Boyle M. Child abuse and chronic pain in a community survey of women. J Interpers Violence. 2007;22:1536–54.
Fillingim RB, Edwards RR. Is self-reported childhood abuse history associated with pain perception among healthy young women and men? Clin J Pain. 2005;21:387–97.
Edwards PW, Zeichner A, Kuczmierczyk AR, Boczkowski J. Familial pain models: the relationship between family history of pain and current pain experience. Pain. 1985;21:379.
Koutantji M, Pearce SA, Oakley DA. The relationship between gender and family history of pain with current pain experience and awareness of pain in others. Pain. 1998;77:25.
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Melotti, R.M., Fanelli, A., Sorella, M.C. (2019). Gender and Pain. In: Tarricone, I., Riecher-Rössler, A. (eds) Health and Gender. Springer, Cham. https://doi.org/10.1007/978-3-030-15038-9_24
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DOI: https://doi.org/10.1007/978-3-030-15038-9_24
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