Abstract
Heparin and protamine are among the most frequently administered drugs during cardiac surgery with cardiopulmonary bypass. Heparin is mostly dosed to achieve full anticoagulation, which is monitored by the activated clotting time. In case of heparin resistance, alternative approaches should be considered, including the use of more sophisticated anticoagulation monitoring techniques. Protamine neutralizes heparin, but exerts anticoagulant effect itself when administered in the absence of heparin.
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Boer, C. (2019). Anticoagulation Management. In: von Heymann, C., Boer, C. (eds) Patient Blood Management in Cardiac Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-15342-7_11
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DOI: https://doi.org/10.1007/978-3-030-15342-7_11
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