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Head and Neck Infections

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Infections in Neutropenic Cancer Patients

Abstract

The head and neck have several compartments with very rich blood and nerve supply. Organisms from the oral cavity and skin can gain access to the vital structures of the head and neck causing severe infection. The infection can spread rapidly to vital locations causing life threathening complications. Prompt diagnosis and therapy are essential especially in neutropenic patients.

In this chapter we will review the most common infections of the head and neck seen in neutropenic patients.

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References

  1. Bayardelle P, Jolivet-Granger M, Larochelle D. Staphylococcal malignant external otitis. Can Med Assoc J. 1982;126(2):155–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Coser PL, Stamm AE, Lobo RC, Pinto JA. Malignant external otitis in infants. Laryngoscope. 1980;90(2):312–6.

    CAS  PubMed  Google Scholar 

  3. Cunningham M, Yu VL, Turner J, Curtin H. Necrotizing otitis externa due to Aspergillus in an immunocompetent patient. Arch Otolaryngol Head Neck Surg. 1988;114(5):554–6.

    Article  CAS  Google Scholar 

  4. Munoz A, Martinez-Chamorro E. Necrotizing external otitis caused by Aspergillus fumigatus: computed tomography and high resolution magnetic resonance imaging in an AIDS patient. J Laryngol Otol. 1998;112(1):98–102.

    Article  CAS  Google Scholar 

  5. Phillips P, Bryce G, Shepherd J, Mintz D. Invasive external otitis caused by Aspergillus. Rev Infect Dis. 1990;12(2):277–81.

    Article  CAS  Google Scholar 

  6. Rubin J, Yu VL. Malignant external otitis: insights into pathogenesis, clinical manifestations, diagnosis, and therapy. Am J Med. 1988;85(3):391–8.

    Article  CAS  Google Scholar 

  7. Davis JC, Gates GA, Lerner C, Davis MG Jr, Mader JT, Dinesman A. Adjuvant hyperbaric oxygen in malignant external otitis. Arch Otolaryngol Head Neck Surg. 1992;118(1):89–93.

    Article  CAS  Google Scholar 

  8. Sreepada GS, Kwartler JA. Skull base osteomyelitis secondary to malignant otitis externa. Curr Opin Otolaryngol Head Neck Surg. 2003;11(5):316–23.

    Article  Google Scholar 

  9. Finer G, Greenberg D, Leibovitz E, Leiberman A, Shelef I, Kapelushnik J. Conservative treatment of malignant (invasive) external otitis caused by Aspergillus flavus with oral itraconazole solution in a neutropenic patient. Scand J Infect Dis. 2002;34(3):227–9.

    Article  Google Scholar 

  10. Al-Noury K, Lotfy A. Computed tomography and magnetic resonance imaging findings before and after treatment of patients with malignant external otitis. Eur Arch Otorhinolaryngol. 2011;268(12):1727–34.

    Article  Google Scholar 

  11. Patterson TF, Thompson GR 3rd, Denning DW, Fishman JA, Hadley S, Herbrecht R, et al. Executive summary: practice guidelines for the diagnosis and management of Aspergillosis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;63(4):433–42.

    Article  Google Scholar 

  12. Ambati BK, Ambati J, Azar N, Stratton L, Schmidt EV. Periorbital and orbital cellulitis before and after the advent of Haemophilus influenzae type B vaccination. Ophthalmology. 2000;107(8):1450–3.

    Article  CAS  Google Scholar 

  13. Rutar T, Cockerham KP. Periorbital zygomycosis (mucormycosis) treated with posaconazole. Am J Ophthalmol. 2006;142(1):187–8.

    Article  Google Scholar 

  14. Cho HJ, Jang MS, Hong SD, Chung SK, Kim HY, Dhong HJ. Prognostic factors for survival in patients with acute invasive fungal rhinosinusitis. Am J Rhinol Allergy. 2015;29(1):48–53.

    Article  Google Scholar 

  15. Davoudi S, Kumar VA, Jiang Y, Kupferman M, Kontoyiannis DP. Invasive mould sinusitis in patients with haematological malignancies: a 10 year single-centre study. J Antimicrob Chemother. 2015;70(10):2899–905.

    Article  CAS  Google Scholar 

  16. Ganesh A, Venugopalan P. Preseptal orbital cellulitis following oral trauma. J Pediatr Ophthalmol Strabismus. 2000;37(5):315–7.

    CAS  PubMed  Google Scholar 

  17. Kamasaki Y, Satoh K, Nishiguchi M, Hoshino T, Fujiwara T. Acute oral complications in a pediatric patient with acute lymphoid leukemia. Pediatr Int. 2016;58(6):484–7.

    Article  Google Scholar 

  18. Peterson DE, Bensadoun RJ, Roila F. Management of oral and gastrointestinal mucositis: ESMO clinical practice guidelines. Ann Oncol. 2011;22(Suppl 6):vi78–84.

    PubMed  PubMed Central  Google Scholar 

  19. Villa A, Sonis ST. Mucositis: pathobiology and management. Curr Opin Oncol. 2015;27(3):159–64.

    Article  CAS  Google Scholar 

  20. Sampson MM, Nanjappa S, Greene JN. Mucositis and oral infections secondary to gram negative rods in patients with prolonged neutropenia. IDCases. 2017;9:101–3.

    Article  Google Scholar 

  21. Terhes G, Piukovics K, Urban E, Nagy E. Four cases of bacteraemia caused by fusobacterium nucleatum in febrile, neutropenic patients. J Med Microbiol. 2011;60.(Pt 7:1046–9.

    Article  Google Scholar 

  22. Kitten T, Munro CL, Zollar NQ, Lee SP, Patel RD. Oral streptococcal bacteremia in hospitalized patients: taxonomic identification and clinical characterization. J Clin Microbiol. 2012;50(3):1039–42.

    Article  Google Scholar 

  23. Pistacchio E. Plaut-Vincent’s angina. Infez Med. 1999;7(4):260–3.

    PubMed  Google Scholar 

  24. Gurvits GE, Tan A. Black hairy tongue syndrome. World J Gastroenterol. 2014;20(31):10845–50.

    Article  Google Scholar 

  25. Iino T, Gondo H, Ohno Y, Minagawa H, Iwasaki H, Maruyama T, et al. Successful foscarnet therapy for mucocutaneous infection with herpes simplex virus in a recipient after unrelated bone marrow transplantation. Bone Marrow Transplant. 1996;18(6):1185–8.

    CAS  PubMed  Google Scholar 

  26. Darville JM, Ley BE, Roome AP, Foot AB. Acyclovir-resistant herpes simplex virus infections in a bone marrow transplant population. Bone Marrow Transplant. 1998;22(6):587–9.

    Article  CAS  Google Scholar 

  27. Botha A, Jacobs F, Postma C. Retrospective analysis of etiology and comorbid diseases associated with Ludwig’s Angina. Ann Maxillofac Surg. 2015;5(2):168–73.

    Article  Google Scholar 

  28. Chow AW. Life-threatening infections of the head and neck. Infect Dis Clin North Am. 1992;14(5):991–1002.

    Article  CAS  Google Scholar 

  29. Kuppalli K, Livorsi D, Talati NJ, Osborn M. Lemierre’s syndrome due to fusobacterium necrophorum. Lancet Infect Dis. 2012;12(10):808–15.

    Article  Google Scholar 

  30. Qiao J, Wang Y, Bai J, Wu Y, Fang H. Concurrence of Sweet’s syndrome, pathergy phenomenon and erythema nodosum-like lesions. An Bras Dermatol. 2015;90(2):237–9.

    Article  Google Scholar 

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Correspondence to Ana Paula Velez MD, FACP .

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Velez, A.P., Greene, J.N., Lamarche, J.A. (2019). Head and Neck Infections. In: Velez, A., Lamarche, J., Greene, J. (eds) Infections in Neutropenic Cancer Patients. Springer, Cham. https://doi.org/10.1007/978-3-030-21859-1_2

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