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Heat Shock Protein 90 and Reproduction in Female Animals: Ovary, Oocyte and Early Embryo

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Heat Shock Protein 90 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 19))

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Abstract

The mammalian heat shock protein 90 (HSP90) is the most conserved member of heat shock protein family (HSP), participating in the regulation of various cellular and physiological processes, and stress adaptation and oncogenic transformation as well. In addition, in different animal reproduction system, HSP90 plays a vital function in the folliculogenesis, oogenesis and embryo development, and also contributes to the development and progress of female reproductive diseases. This chapter focuses on the general structure, transcriptional regulation (expression and isoforms) and inhibitors of HSP90 family, and their particular roles in animal female reproductive events.

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Abbreviations

AKT:

Protein kinase B

AP1:

Activator protein 1

ATP/ADP:

Adenosine triphosphate/adenosine diphosphate

CDK1:

Cyclin dependent kinase 1

CDK4:

Cyclin dependent kinase 4

COCs:

Cumulus-oocyte complexes

c-Src:

Proto-oncogene tyrosine-protein kinase Src

CTD:

C-terminal domain

dpc:

Day post-coital

ERBB2:

Erb-B2 receptor tyrosine kinase 2

ERK:

Extracellular regulated protein kinases

FLT3:

FMS-Like tyrosine kinase-3

GA:

Geldanamycin

GC:

Glucocorticoids

GR:

Glucocorticoid receptor

GRP94:

94-kDa glucose-regulated protein

GV:

Germinal vesicle

GVBD:

Germinal vesicle breakdown

HNF4A:

Hepatocyte nuclear factor 4 alpha

HOP:

HSP70-HSP90 organizing protein

HSE:

Heat shock element

HSF:

Heat shock factor

HSP:

Heat shock proteins

HSP90:

Heat shock protein 90

HSP90α:

Heat shock protein 90 alpha family class A member 1

HSP90β:

Heat shock protein 90 alpha family class B member 1

IVM:

In vitro maturation

JAK/STAT:

Janus kinase-signal transducer and activator of transcription

MAPK:

Mitogen-activated protein kinases

MD:

Middle domain

MII:

Metaphase II

Mos:

MOS proto-oncogene, serine/threonine kinase

MPF:

Maturation-promoting factor

NF-κB:

Nuclear factor kappa-light-chain-enhancer of activated B cells

NTD:

N-terminal domain

NV:

Novobiocin

OGT:

Beta-O-linked N-acetylglucosamine transferase

PB1:

First polar body

PGCs:

Primordial germ cells

PI3K/PTEN/AKT/mTOR:

Phosphoinositide 3-kinase/phosphatase and tensin homologue/protein kinase B/mammalian target of rapamycin

PPARγ:

Proliferator-activated receptor-γ

RAD:

Radicicol

San A:

Sansalvamide A

San A-amide:

Sansalvamide A-amide

STAT5:

Signal transducer and activator of transcription 5

TRAP-1:

Tumor necrosis factor receptor-associated protein 1

VEGFR2:

VEGF receptor 2

YTHDF2:

YTH N6-methyladenosine RNA binding protein 2

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Acknowledgements

Our original work cited herein was supported by the National Natural Science Foundation of China (grant number 31472098) and the Start-up grant from Northeast Agricultural University (C.X.Y.).

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  1. College of Animal Science, Yangtze University, Jingzhou, Hubei, China

    Yu-Wei Yang & Cai-Xia Yang

  2. College of Animal Science and Technology, Northeast Agricultural University, Harbin, Heilongjiang, China

    Yu-Wei Yang, Lu Chen & Cai-Xia Yang

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Correspondence to Cai-Xia Yang .

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  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Yang, YW., Chen, L., Yang, CX. (2019). Heat Shock Protein 90 and Reproduction in Female Animals: Ovary, Oocyte and Early Embryo. In: Asea, A., Kaur, P. (eds) Heat Shock Protein 90 in Human Diseases and Disorders. Heat Shock Proteins, vol 19. Springer, Cham. https://doi.org/10.1007/978-3-030-23158-3_23

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