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Hsp90 in the Migration of Primordial Germ Cells: A Model to Study Long-Distance Cell Migration and Perhaps Cancer?

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Heat Shock Protein 90 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 19))

Abstract

Primordial Germ Cells (PGC) are the progenitors of the germ-line and differentiate into spermatozoa or oocytes. They are responsible for the transmission of genetic and epigenetic information from one generation to the other. Since the nineteenth century, PGCs have been investigated using different techniques. Regardless of their mode of specification, inheritance or induction, PGCs arise early in development and migrate by a combination of passive and active movements towards the gonadic ridges. The migration of PGCs is very similar to the path taken by metastasis and germ cells are very often proposed as a model for the study of cell migration. Their pathway of migration is regulated by different signals that interact with Hsp90, an ATP-dependent chaperone associated with numerous tumors and used to grade the malignancy. Furthermore, some of the signals regulating PGCs have been proved to have a role in different cancers. This underlines the idea that PGCs could be an interesting tool to study long-distance cell migration and perhaps cancer.

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Abbreviations

actr2:

Actin related protein 2 homolog

alk2:

Activin receptor-like kinase-2

Bmp:

Bone morphogenetic proteins

Bmpr:

Bone morphogenetic protein receptor

EMT:

Epithelial-mesenchymal transition

GR:

Gonadal ridge

Hsp:

Heat shock protein

MOTC:

Microtubule organizer center

PGC:

Primordial germ cells

ROCK/RhoA:

Rho-associated protein kinase

TGFβ:

Transforming growth factor β

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Acknowledgements

The authors thank Mrs. M. Choa-Duterre for histological sections.

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Authors and Affiliations

  1. Laboratory of Anatomy, Biomechanics and Organogenesis, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium

    Marie Lejong, Nathalie Vanmuylder & Stéphane Louryan

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  1. Marie Lejong
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  2. Nathalie Vanmuylder
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  3. Stéphane Louryan
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Correspondence to Stéphane Louryan .

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Editors and Affiliations

  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Lejong, M., Vanmuylder, N., Louryan, S. (2019). Hsp90 in the Migration of Primordial Germ Cells: A Model to Study Long-Distance Cell Migration and Perhaps Cancer?. In: Asea, A., Kaur, P. (eds) Heat Shock Protein 90 in Human Diseases and Disorders. Heat Shock Proteins, vol 19. Springer, Cham. https://doi.org/10.1007/978-3-030-23158-3_4

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