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Centriole Positioning: Not Just a Little Dot in the Cell

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The Golgi Apparatus and Centriole

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 67))

Abstract

Organelle positioning as many other morphological parameters in a cell is not random. Centriole positioning as centrosomes or ciliary basal bodies is not an exception to this rule in cell biology. Indeed, centriole positioning is a tightly regulated process that occurs during development, and it is critical for many organs to function properly, not just during development but also in the adulthood. In this book chapter, we overview our knowledge on centriole positioning in different and highly specialized animal cells like photoreceptor or ependymal cells. We will also discuss recent advances in the discovery of molecular pathways involved in this process, mostly related to the cytoskeleton and the cell polarity pathways. And finally, we present quantitative methods that have been used to assess centriole positioning in different cell types although mostly in epithelial cells.

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Acknowledgments

This work was supported by BFU2014-54699-P and BFU2017-85547-P grants from the Ministry of Economy to J.M. C-G. and GR15164 and GR18116 from Junta de Extremadura to F.C. Á.-C.R. S.G-J. was a recipient of a Fellowship from the Universidad de Extremadura, and S.D-Ch was a recipient of a Fellowship from Junta de Extremadura. All Spanish funding is cosponsored by the European Union FEDER program.

J.M. C-G was a recipient of an “Atraccion y Retencion de talento” contract from the GOBEX (Extremadura government) and was recipient of a Ramón y Cajal contract (RYC-2015-17867).

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The authors declare no competing financial interests.

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Authors and Affiliations

  1. Facultad de Ciencias, Departamento de Bioquímica, Biología Molecular y Genética, Universidad de Extremadura, Badajoz, Spain

    Angel-Carlos Roman, Sergio Garrido-Jimenez, Selene Diaz-Chamorro, Francisco Centeno & Jose Maria Carvajal-Gonzalez

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  1. Angel-Carlos Roman
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  2. Sergio Garrido-Jimenez
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  3. Selene Diaz-Chamorro
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  4. Francisco Centeno
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  5. Jose Maria Carvajal-Gonzalez
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Correspondence to Jose Maria Carvajal-Gonzalez .

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  1. Department of Surgery, Houston Methodist Hospital, Houston, TX, USA

    Malgorzata Kloc

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Roman, AC., Garrido-Jimenez, S., Diaz-Chamorro, S., Centeno, F., Carvajal-Gonzalez, J.M. (2019). Centriole Positioning: Not Just a Little Dot in the Cell. In: Kloc, M. (eds) The Golgi Apparatus and Centriole. Results and Problems in Cell Differentiation, vol 67. Springer, Cham. https://doi.org/10.1007/978-3-030-23173-6_8

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