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Behçet Syndrome and Microbes

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Behçet Syndrome

Abstract

Behçet syndrome (BS) is generally thought to have a complex genetic background where both innate and adaptive immune systems are activated through environmental factors including infections and autoantigens. There are clues to support the role of several different microorganisms including viruses and bacteria, which may be using a common pathway to trigger or activate the inflammation in BS through molecular mimicry. Due to the significant homology between microbial and human heat shock proteins (HSPs), it is suggested that HSPs could be such common triggers. Recent studies on microbiome of patients with BS show distinct features that may help us understand its pathogenesis.

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Authors and Affiliations

  1. Queen Mary University of London- Barts and The London School of Medicine and Dentistry, London Behçet’s Centre, London, UK

    Farida Fortune

  2. Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, School of Medicine, Istanbul, Turkey

    Gulen Hatemi

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  1. Farida Fortune
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  2. Gulen Hatemi
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Correspondence to Farida Fortune .

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Editors and Affiliations

  1. School of Medicine, New York University, New York, NY, USA

    Yusuf Yazici

  2. Department of Internal Medicine, Istanbul University, Istanbul, Turkey

    Gulen Hatemi

  3. Department of Rheumatology, Istanbul University, Istanbul, Turkey

    Emire Seyahi

  4. Department of Medicine, Academic Hospital, Istanbul, Turkey

    Hasan Yazici

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Fortune, F., Hatemi, G. (2020). Behçet Syndrome and Microbes. In: Yazici, Y., Hatemi, G., Seyahi, E., Yazici, H. (eds) Behçet Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-030-24131-5_13

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