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Laparoscopic Resections for Colorectal Cancer Liver Metastases

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Colorectal Cancer Liver Metastases

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Abstract

Nowadays, laparoscopic liver resections (LLR) are routinely performed in many centers worldwide for the treatment of benign and malignant liver lesions. Colorectal liver metastases (CRLM) represent the most frequent malignant indication to liver resection in Western countries, and the available evidence supports the advantages of LLR over open liver resections (OLR) in terms of perioperative short-term outcomes. Furthermore, despite initial skepticism, the long-term oncological outcomes appear safe and comparable to OLR. The clinical presentation of CRLM differs from patient to patient in terms of time interval from the diagnosis of the primary tumor (synchronous vs. metachronous) and in terms of location, size, and number of lesions, making the management of patients challenging. Surgical resection is associated with long-term survivals, and laparoscopic approach has been described in each setting with different levels of evidence. Selection criteria should take into account patients’ characteristics and disease presentation as well as learning curve and expertise in order to achieve improvement in postoperative results, maintaining safe oncological outcomes.

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References

  1. Berardi G, Van Cleven S, Fretland AA, et al. Evolution of laparoscopic liver surgery from innovation to implementation to mastery: perioperative and oncologic outcomes of 2,238 patients from 4 European specialized centers. J Am Coll Surg. 2017;225(5):639–49.

    Article  PubMed  Google Scholar 

  2. Ghezzi F, Cromi A, Ditto A, et al. Laparoscopic versus open radical hysterectomy for stage IB2-IIB cervical cancer in the setting of neoadjuvant chemotherapy: a multi-institutional cohort study. Ann Surg Oncol. 2013;20(6):2007–15.

    Article  PubMed  Google Scholar 

  3. Guillou PJ, Quirke P, Thorpe H, et al. Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet. 2005;365(9472):1718–26.

    Article  PubMed  Google Scholar 

  4. Luketich JD, Pennathur A, Awais O, et al. Outcomes after minimally invasive esophagectomy: review of over 1000 patients. Ann Surg. 2012;256(1):95–103.

    Article  PubMed  Google Scholar 

  5. Trabulsi EJ, Guillonneau B. Laparoscopic radical prostatectomy. J Urol. 2005;173(4):1072–9.

    Article  PubMed  Google Scholar 

  6. Gagner M, Rogula T, Selzer D. Laparoscopic liver resection: benefits and controversies. Surg Clin North Am. 2004;84(2):451–62.

    Article  PubMed  Google Scholar 

  7. Reich H, McGlynn F, DeCaprio J, et al. Laparoscopic excision of benign liver lesions. Obstet Gynecol. 1991;78(5 Pt 2):956–8.

    CAS  PubMed  Google Scholar 

  8. Azagra JS, Goergen M, Gilbart E, et al. Laparoscopic anatomical (hepatic) left lateral segmentectomy-technical aspects. Surg Endosc. 1996;10(7):758–61.

    Article  CAS  PubMed  Google Scholar 

  9. Huscher CG, Napolitano C, Chiodini S, et al. Hepatic resections through the laparoscopic approach. Ann Ital Chir. 1997;68(6):791–7.

    CAS  PubMed  Google Scholar 

  10. Belli G, Limongelli P, Fantini C, et al. Laparoscopic and open treatment of hepatocellular carcinoma in patients with cirrhosis. Br J Surg. 2009;96(9):1041–8.

    Article  CAS  PubMed  Google Scholar 

  11. Wakabayashi G, Cherqui D, Geller DA, et al. Recommendations for laparoscopic liver resection: a report from the second international consensus conference held in Morioka. Ann Surg. 2015;261(4):619–29.

    PubMed  Google Scholar 

  12. Buell JF, Cherqui D, Geller DA, et al. The international position on laparoscopic liver surgery: the Louisville statement, 2008. Ann Surg. 2009;250(5):825–30.

    Article  PubMed  Google Scholar 

  13. Cherqui D, Husson E, Hammoud R, et al. Laparoscopic liver resections: a feasibility study in 30 patients. Ann Surg. 2000;232(6):753–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Descottes B, Lachachi F, Sodji M, et al. Early experience with laparoscopic approach for solid liver tumors: initial 16 cases. Ann Surg. 2000;232(5):641–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Nguyen KT, Gamblin TC, Geller DA. World review of laparoscopic liver resection-2,804 patients. Ann Surg. 2009;250(5):831–41.

    Article  PubMed  Google Scholar 

  16. Ciria R, Cherqui D, Geller DA, et al. Comparative short-term benefits of laparoscopic liver resection: 9000 cases and climbing. Ann Surg. 2016;263(4):761–77.

    Article  PubMed  Google Scholar 

  17. Schiffman SC, Kim KH, Tsung A, et al. Laparoscopic versus open liver resection for metastatic colorectal cancer: a metaanalysis of 610 patients. Surgery. 2015;157(2):211–22.

    Article  PubMed  Google Scholar 

  18. Xiong JJ, Altaf K, Javed MA, et al. Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma. World J Gastroenterol. 2012;18(45):6657–68.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Sugihara K, Uetake H. Therapeutic strategies for hepatic metastasis of colorectal cancer: overview. J Hepatobiliary Pancreat Sci. 2012;19(5):523–7.

    Article  PubMed  Google Scholar 

  20. Simmonds PC, Primrose JN, Colquitt JL, et al. Surgical resection of hepatic metastases from colorectal cancer: a systematic review of published studies. Br J Cancer. 2006;94(7):982–99.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Nguyen KT, Laurent A, Dagher I, et al. Minimally invasive liver resection for metastatic colorectal cancer: a multi-institutional, international report of safety, feasibility, and early outcomes. Ann Surg. 2009;250(5):842–8.

    Article  PubMed  Google Scholar 

  22. Cannon RM, Scoggins CR, Callender GG, et al. Laparoscopic versus open resection of hepatic colorectal metastases. Surgery. 2012;152(4):567–73; discussion 573-4.

    Article  PubMed  Google Scholar 

  23. Castaing D, Vibert E, Ricca L, et al. Oncologic results of laparoscopic versus open hepatectomy for colorectal liver metastases in two specialized centers. Ann Surg. 2009;250(5):849–55.

    Article  PubMed  Google Scholar 

  24. Cheung TT, Poon RT, Yuen WK, et al. Outcome of laparoscopic versus open hepatectomy for colorectal liver metastases. ANZ J Surg. 2013;83(11):847–52.

    Article  PubMed  Google Scholar 

  25. Guerron AD, Aliyev S, Agcaoglu O, et al. Laparoscopic versus open resection of colorectal liver metastasis. Surg Endosc. 2013;27(4):1138–43.

    Article  PubMed  Google Scholar 

  26. Hu MG, Ou-yang CG, Zhao GD, et al. Outcomes of open versus laparoscopic procedure for synchronous radical resection of liver metastatic colorectal cancer: a comparative study. Surg Laparosc Endosc Percutan Tech. 2012;22(4):364–9.

    Article  PubMed  Google Scholar 

  27. Huh JW, Koh YS, Kim HR, et al. Comparison of laparoscopic and open colorectal resections for patients undergoing simultaneous R0 resection for liver metastases. Surg Endosc. 2011;25(1):193–8.

    Article  PubMed  Google Scholar 

  28. Kazaryan AM, Marangos IP, Rosok BI, et al. Laparoscopic resection of colorectal liver metastases: surgical and long-term oncologic outcome. Ann Surg. 2010;252(6):1005–12.

    Article  PubMed  Google Scholar 

  29. Mala T, Edwin B, Gladhaug I, et al. A comparative study of the short-term outcome following open and laparoscopic liver resection of colorectal metastases. Surg Endosc. 2002;16(7):1059–63.

    Article  CAS  PubMed  Google Scholar 

  30. Montalti R, Berardi G, Laurent S, et al. Laparoscopic liver resection compared to open approach in patients with colorectal liver metastases improves further resectability: oncological outcomes of a case-control matched-pairs analysis. Eur J Surg Oncol. 2014;40(5):536–44.

    Article  CAS  PubMed  Google Scholar 

  31. Topal H, Tiek J, Aerts R, et al. Outcome of laparoscopic major liver resection for colorectal metastases. Surg Endosc. 2012;26(9):2451–5.

    Article  PubMed  Google Scholar 

  32. Cheng Y, Zhang L, Li H, et al. Laparoscopic versus open liver resection for colorectal liver metastases: a systematic review. J Surg Res. 2017;220:234–46.

    Article  PubMed  Google Scholar 

  33. Zhang XL, Liu RF, Zhang D, et al. Laparoscopic versus open liver resection for colorectal liver metastases: a systematic review and meta-analysis of studies with propensity score-based analysis. Int J Surg. 2017;44:191–203.

    Article  PubMed  Google Scholar 

  34. Hallet J, Beyfuss K, Memeo R, et al. Short and long-term outcomes of laparoscopic compared to open liver resection for colorectal liver metastases. Hepatobiliary Surg Nutr. 2016;5(4):300–10.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Luo LX, Yu ZY, Bai YN. Laparoscopic hepatectomy for liver metastases from colorectal cancer: a meta-analysis. J Laparoendosc Adv Surg Tech A. 2014;24(4):213–22.

    Article  PubMed  Google Scholar 

  36. Tian ZQ, Su XF, Lin ZY, et al. Meta-analysis of laparoscopic versus open liver resection for colorectal liver metastases. Oncotarget. 2016;7(51):84544–55.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Wei M, He Y, Wang J, et al. Laparoscopic versus open hepatectomy with or without synchronous colectomy for colorectal liver metastasis: a meta-analysis. PLoS One. 2014;9(1):e87461.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  38. Xie SM, Xiong JJ, Liu XT, et al. Laparoscopic versus open liver resection for colorectal liver metastases: a comprehensive systematic review and meta-analysis. Sci Rep. 2017;7(1):1012.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  39. Zhou Y, Xiao Y, Wu L, et al. Laparoscopic liver resection as a safe and efficacious alternative to open resection for colorectal liver metastasis: a meta-analysis. BMC Surg. 2013;13:44.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Beppu T, Wakabayashi G, Hasegawa K, et al. Long-term and perioperative outcomes of laparoscopic versus open liver resection for colorectal liver metastases with propensity score matching: a multi-institutional Japanese study. J Hepatobiliary Pancreat Sci. 2015;22(10):711–20.

    Article  PubMed  Google Scholar 

  41. Younes RN, Rogatko A, Brennan MF. The influence of intraoperative hypotension and perioperative blood transfusion on disease-free survival in patients with complete resection of colorectal liver metastases. Ann Surg. 1991;214(2):107–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Fretland AA, Sokolov A, Postriganova N, et al. Inflammatory response after laparoscopic versus open resection of colorectal liver metastases: data from the Oslo-CoMet trial. Medicine (Baltimore). 2015;94(42):e1786.

    Article  CAS  Google Scholar 

  43. Kasai M, Van Damme N, Berardi G, et al. The inflammatory response to stress and angiogenesis in liver resection for colorectal liver metastases: a randomized controlled trial comparing open versus laparoscopic approach. Acta Chir Belg. 2018;118(3):172–80.

    Article  PubMed  Google Scholar 

  44. Fretland AA, Dagenborg VJ, Bjornelv GMW, et al. Laparoscopic versus open resection for colorectal liver metastases: the OSLO-COMET randomized controlled trial. Ann Surg. 2018;267(2):199–207.

    Article  PubMed  Google Scholar 

  45. Mala T, Edwin B. Role and limitations of laparoscopic liver resection of colorectal metastases. Dig Dis. 2005;23(2):142–50.

    Article  PubMed  Google Scholar 

  46. Cherqui D. Evolution of laparoscopic liver resection. Br J Surg. 2016;103(11):1405–7.

    Article  CAS  PubMed  Google Scholar 

  47. Chang S, Laurent A, Tayar C, et al. Laparoscopy as a routine approach for left lateral sectionectomy. Br J Surg. 2007;94(1):58–63.

    Article  CAS  PubMed  Google Scholar 

  48. Kawaguchi Y, Fuks D, Kokudo N, et al. Difficulty of laparoscopic liver resection: proposal for a new classification. Ann Surg. 2017.

    Google Scholar 

  49. Abu Hilal M, Aldrighetti L, Dagher I, et al. The Southampton consensus guidelines for laparoscopic liver surgery: from indication to implementation. Ann Surg. 2018;268(1):11–8.

    Article  PubMed  Google Scholar 

  50. Halls MC, Cipriani F, Berardi G, et al. Conversion for unfavorable intraoperative events results in significantly worse outcomes during laparoscopic liver resection: lessons learned from a multicenter review of 2861 cases. Ann Surg. 2018;268(6):1051–7.

    Article  PubMed  Google Scholar 

  51. Aghayan DL, Pelanis E, Avdem Fretland A, et al. Laparoscopic parenchyma-sparing liver resection for colorectal metastases. Radiol Oncol. 2018;52(1):36–41.

    Article  PubMed  Google Scholar 

  52. Dagher I, O'Rourke N, Geller DA, et al. Laparoscopic major hepatectomy: an evolution in standard of care. Ann Surg. 2009;250(5):856–60.

    Article  PubMed  Google Scholar 

  53. Kasai M, Cipriani F, Gayet B, et al. Laparoscopic versus open major hepatectomy: a systematic review and meta-analysis of individual patient data. Surgery. 2018;163(5):985–95.

    Article  PubMed  Google Scholar 

  54. Martin RC, Scoggins CR, McMasters KM. Laparoscopic hepatic lobectomy: advantages of a minimally invasive approach. J Am Coll Surg. 2010;210(5):627-34–634-6.

    Article  Google Scholar 

  55. Ratti F, Cipriani F, Ariotti R, et al. Laparoscopic major hepatectomies: current trends and indications. A comparison with the open technique. Updat Surg. 2015;67(2):157–67.

    Article  Google Scholar 

  56. Tozzi F, Berardi G, Vierstraete M, et al. Laparoscopic versus open approach for formal right and left hepatectomy: a propensity score matching analysis. World J Surg. 2018;42(8):2627–34.

    Article  PubMed  Google Scholar 

  57. Adam R. Chemotherapy and surgery: new perspectives on the treatment of unresectable liver metastases. Ann Oncol. 2003;14(Suppl 2):ii13–6.

    PubMed  Google Scholar 

  58. Di Fabio F, Whistance R, Rahman S, et al. Exploring the role of laparoscopic surgery in two-stage hepatectomy for bilobar colorectal liver metastases. J Laparoendosc Adv Surg Tech A. 2012;22(7):647–50.

    Article  PubMed  Google Scholar 

  59. Fuks D, Nomi T, Ogiso S, et al. Laparoscopic two-stage hepatectomy for bilobar colorectal liver metastases. Br J Surg. 2015;102(13):1684–90.

    Article  CAS  PubMed  Google Scholar 

  60. Jain G, Parmar J, Mohammed MM, et al. “Stretching the limits of laparoscopic surgery”: two-stage laparoscopic liver resection. J Laparoendosc Adv Surg Tech A. 2010;20(1):51–4.

    Article  PubMed  Google Scholar 

  61. Machado MA, Makdissi FF, Surjan RC, et al. Two-stage laparoscopic liver resection for bilateral colorectal liver metastasis. Surg Endosc. 2010;24(8):2044–7.

    Article  CAS  PubMed  Google Scholar 

  62. de Jong MC, Pulitano C, Ribero D, et al. Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: an international multi-institutional analysis of 1669 patients. Ann Surg. 2009;250(3):440–8.

    PubMed  Google Scholar 

  63. Wicherts DA, de Haas RJ, Salloum C, et al. Repeat hepatectomy for recurrent colorectal metastases. Br J Surg. 2013;100(6):808–18.

    Article  CAS  PubMed  Google Scholar 

  64. Nomi T, Fuks D, Ogiso S, et al. Second and third laparoscopic liver resection for patients with recurrent colorectal liver metastases. Ann Surg. 2016;263(5):e68–72.

    Article  PubMed  Google Scholar 

  65. van der Poel MJ, Barkhatov L, Fuks D, et al. Multicentre propensity score-matched study of laparoscopic versus open repeat liver resection for colorectal liver metastases. Br J Surg. 2019.

    Google Scholar 

  66. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7–34.

    Article  PubMed  Google Scholar 

  67. Martin RC 2nd, Augenstein V, Reuter NP, et al. Simultaneous versus staged resection for synchronous colorectal cancer liver metastases. J Am Coll Surg. 2009;208(5):842–50. discussion 850-2

    Article  PubMed  Google Scholar 

  68. Moris D, Tsilimigras DI, Machairas N, et al. Laparoscopic synchronous resection of colorectal cancer and liver metastases: a systematic review. J Surg Oncol. 2019;119(1):30–9.

    Article  PubMed  Google Scholar 

  69. Reddy SK, Pawlik TM, Zorzi D, et al. Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysis. Ann Surg Oncol. 2007;14(12):3481–91.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Center for Advanced Treatment of HBP Diseases, Ageo Central General Hospital, Ageo Shi, Saitama, Japan

    Giammauro Berardi & Go Wakabayashi

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  1. Giammauro Berardi
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  2. Go Wakabayashi
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Editors and Affiliations

  1. National Cancer Institute, Rio de Janeiro, Brazil

    Mauro Monteiro Correia

  2. Banner MD Anderson Cancer Center, Phoenix, AZ, USA

    Michael A. Choti

  3. Virginia Mason Medical Center, Seattle, WA, USA

    Flavio G. Rocha

  4. Center for Advanced Treatment of HBP Diseases, Ageo Central General Hospital, Ageo Shi, Saitama, Japan

    Go Wakabayashi

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Berardi, G., Wakabayashi, G. (2020). Laparoscopic Resections for Colorectal Cancer Liver Metastases. In: Correia, M., Choti, M., Rocha, F., Wakabayashi, G. (eds) Colorectal Cancer Liver Metastases. Springer, Cham. https://doi.org/10.1007/978-3-030-25486-5_28

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  • DOI: https://doi.org/10.1007/978-3-030-25486-5_28

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