Skip to main content

Acute Hypoxemic Respiratory Failure in Immunocompromised Patients: The Role of Non-invasive Ventilation and High-Flow Oxygen Therapy

  • Chapter
  • First Online:
Ventilatory Support and Oxygen Therapy in Elder, Palliative and End-of-Life Care Patients

Abstract

Over the last two decades, cancer survival rates have been progressively improving. This is believed to be due to earlier detection, advances in treatment options, and better supportive care [1]. As a result, more immunocompromised patients are seen in the intensive care unit (ICU) with a specific increase in the number of elderly patients. One of the major causes of ICU admission in this age group is the development of acute hypoxic respiratory failure (ARF), which has a rate ranging between 10 and 50% in patients suffering from cancer based on the most recent available data [2].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 119.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Henley SJ, Sing SO, King J, et al. Invasive cancer incidence and survival—United States, 2012. MMWR Morb Mortal Wkly Rep. 2015;64(49):1353–8.

    Article  Google Scholar 

  2. Soubani AO. Critical care prognosis and outcomes in patients with cancer. Clin Chest Med. 2017;38:333–53.

    Article  Google Scholar 

  3. Soares M, Depuydt PO, Salluh JI. Mechanical ventilation in cancer patients: clinical characteristics and outcomes. Crit Care Clin. 2010;26(1):41–58.

    Article  Google Scholar 

  4. Azoulay E, Lemiale V, Mokart D, et al. Acute respiratory distress syndrome in patients with malignancies. Intensive Care Med. 2014;40(8):1106–14.

    Article  Google Scholar 

  5. Soubani AO, Shehada E, Chen W, et al. The outcome of cancer patients with acute respiratory distress syndrome. J Crit Care. 2014;29(1):183.e7–12.

    Article  Google Scholar 

  6. Moreau AS, Peyrony O, Lemiale V, et al. Acute respiratory failure in patients with hematological malignancies. Clin Chest Med. 2017;38:355–62.

    Article  Google Scholar 

  7. Gajic O, Dabbagh O, Park PK, et al. Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multi-center cohort study. Am J Respir Crit Care Med. 2011;183(4):462–70.

    Article  Google Scholar 

  8. Azoulay E, Mokart D, Pene F, et al. Outcomes of critically ill patients with hematological malignancies: prospective multicenter data from France and Belgium—a Group de Recherche Respiratoire en Reanimation Onco-Hematologique study. J Clin Oncol. 2013;3(22):2810–8.

    Article  Google Scholar 

  9. International consensus conference in intensive care medicine: noninvasive positive pressure ventilation in acute respiratory failure. Am J Respir Crit Care Med. 2001;163:283–91.

    Google Scholar 

  10. Hilbert G, Gruson D, Vargas F, et al. Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure. N Engl J Med. 2001;344(7):481–7.

    Article  CAS  Google Scholar 

  11. Keenan SP, Sinuff T, Burns KE, et al. Clinical practice guidelines for the use of noninvasive positive pressure ventilation and noninvasive continuous positive airway pressure in the acute setting. CMAJ. 2011;183(3):E195–214.

    Article  Google Scholar 

  12. Gristina GR, Antonelli M, Conti G, et al. GiViTL (Italian Group for the Evaluation of Interventions in Intensive Care Medicine). Noninvasive versus invasive ventilation for acute respiratory failure in patients with hematologic malignancies: a 5-year multicenter observational survey. Crit Care Med. 2011;39(10):2232–9.

    Article  Google Scholar 

  13. Rathi NK, Haque SA, Nates R, et al. Noninvasive positive pressure ventilation vs invasive mechanical ventilation as first-line therapy for acute hypoxemic respiratory failure in cancer patients. J Crit Care. 2017;39:56–61.

    Article  Google Scholar 

  14. Johnson C, Frei C, Metersky M, et al. Non-invasive mechanical ventilation and mortality in elderly immunocompromised patients hospitalized with pneumonia: a retrospective cohort study. BMC Pulm Med. 2014;14:7.

    Article  Google Scholar 

  15. Huang HB, Peng JM, Weng L, et al. High-flow oxygen therapy in immunocompromised patients with acute respiratory failure: a review and meta-analysis. J Crit Care. 2018;43:300–5.

    Article  Google Scholar 

  16. Wang T, Liu G, He K, et al. The efficacy of initial ventilation strategy for adult immunocompromised patients with severe acute hypoxemic respiratory failure: study protocol for a multicenter randomized controlled trial (VENIM). BMC Pulm Med. 2017;17:127.

    Article  Google Scholar 

  17. Sztrymf B, Messika J, Bertrand F, Hurel D, Leon R, Dreyfuss D, Ricard JD. Beneficial effects of humidified high flow nasal oxygen in critical care patients: a prospective pilot study. Intensive Care Med. 2011;37(11):1780–6.

    Article  CAS  Google Scholar 

  18. Lenglet H, Sztrymf B, Leroy C, Brun P, Dreyfuss D, Ricard JD. Humidified high flow nasal oxygen during respiratory failure in the emergency department: feasibility and efficacy. Respir Care. 2012;57(11):1873–8.

    Article  Google Scholar 

  19. Maggiore SM, Idone FA, Vaschetto R, Festa R, Cataldo A, Antonicelli F, et al. Nasal high-flow versus Venturi mask oxygen therapy after extubation. Effects on oxygenation, comfort, and clinical outcome. Am J Respir Crit Care Med. 2014;190(3):282–8.

    Article  Google Scholar 

  20. Roca O, Riera J, Torres F, Masclans JR. High-flow oxygen therapy in acute respiratory failure. Respir Care. 2010;55(4):408–13.

    Google Scholar 

  21. Sztrymf B, Messika J, Mayot T, Lenglet H, Dreyfuss D, Ricard JD. Impact of high-flow nasal cannula oxygen therapy on intensive care unit patients with acute respiratory failure: a prospective observational study. J Crit Care. 2012;27(3):324.e9–13.

    Article  Google Scholar 

  22. Kim WY, Sung H, Hong SB, et al. Predictors of high flow nasal cannula failure in immunocompromised patients with acute respiratory failure due to non-HIV pneumocystis pneumonia. J Thorac Dis. 2017;9(9):3013–22.

    Article  Google Scholar 

  23. Clinical effect of the association of noninvasive ventilation and high flow nasal oxygen therapy in resuscitation of patients with acute lung injury (FLORALI Study). https://clinicaltrials.gov/ct2/show/NCT01320384. Accessed 7 Apr 2015.

  24. Nagata K, Morimoto T, Fujimoto D, et al. Efficacy of high-flow nasal cannula therapy in acute hypoxemic respiratory failure: decreased use of mechanical ventilation. Respir Care. 2015;60(10):1390–6.

    Article  Google Scholar 

  25. Lemiale V, Mokart D, Resche-Rigon M, et al. Effect of noninvasive ventilation vs oxygen therapy on mortality among immunocompromised patients with acute respiratory failure. A randomized clinical trial. JAMA. 2015;314(16):1711–9.

    Article  CAS  Google Scholar 

  26. Azoulay E, Kouatchet A, Jaber S, et al. Noninvasive mechanical ventilation in patients having declined tracheal intubation. Intensive Care Med. 2013;39(2):292–301.

    Article  Google Scholar 

  27. Frat JP, Ragot S, Girault C, et al. Effect of non-invasive oxygenation strategies in immunocompromised patients with severe acute respiratory failure: a post-hoc analysis of a randomized trial. Lancet Respir Med. 2016;4:646–52.

    Article  Google Scholar 

  28. Lee HY, Rhee CK, Lee JW. Feasibility of high-flow nasal cannula oxygen therapy for acute respiratory failure for patients with hematologic malignancies: a retrospective single-center trial. J Crit Care. 2015;30:773–7.

    Article  Google Scholar 

  29. Huang HB, Xu B, Liu GY, et al. Use on noninvasive ventilation in immunocompromised patients with acute respiratory failure: a systematic review and meta-analysis. Crit Care. 2017;21:4.

    Article  Google Scholar 

  30. Azoulay E, Lemiale V, Mokart D, et al. High-flow nasal oxygen vs. standard oxygen therapy in immunocompromised patients with acute respiratory failure: study protocol for a randomized controlled trial. Trials. 2018;19:157.

    Article  Google Scholar 

  31. Scala R. Challenges on non-invasive ventilation to treat acute respiratory failure in elderly. BMC Pulm Med. 2016;16:150.

    Article  Google Scholar 

  32. Quill C, Quill T. Palliative use of noninvasive ventilation: navigating murky waters. J Palliat Med. 2014;17(6):657–61.

    Article  Google Scholar 

  33. Curtis JR, Cook DJ, Sinuff T, et al. Society of Critical Care Medicine palliative non-invasive positive ventilation task force. Non-invasive positive pressure ventilation in critical care and palliative care settings: understanding the goals of therapy. Crit Care Med. 2007;35:932–9.

    Article  Google Scholar 

  34. Nava S, Ferrer M, Esquinas A. Palliative use of non-invasive ventilation in end-of-life patients with solid tumors: a randomized feasibility trial. Lancet Oncol. 2013;14:219–27.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ayman O. Soubani .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Alsunaid, S.R., Soubani, A.O. (2020). Acute Hypoxemic Respiratory Failure in Immunocompromised Patients: The Role of Non-invasive Ventilation and High-Flow Oxygen Therapy. In: Esquinas, A., Vargas, N. (eds) Ventilatory Support and Oxygen Therapy in Elder, Palliative and End-of-Life Care Patients . Springer, Cham. https://doi.org/10.1007/978-3-030-26664-6_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-26664-6_14

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-26663-9

  • Online ISBN: 978-3-030-26664-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics