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Biofunctional Nanoparticles for Protein Separation, Purification and Detection

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Horizons in Bioprocess Engineering

Abstract

Proteins are bio-macromolecules of long amino acid chains with several significant applications in living cells. It is the building block of tissues, enzymes, hormones, bones, muscles, cartilage, blood, skin and biological fluids. Proteins in biological fluids exist in combination with cells, DNA, RNA and other proteins. This requires effective separation and purification mechanisms to detect, isolate and characterize specific proteins from biological fluids. Numerous conventional methods are available for separation, purification and detection of proteins. However, these methods are challenged with several drawbacks including low separation efficiency, low purity levels, use of complex separation and purification processes, requirement of stringent purification steps, and lower detection sensitivity in complex biofluids. Application of nanoparticles presents a strategy to address the challenges associated with protein separation , purification and detection . This is due to the unique properties of nanoparticles including enhanced surface area to volume ratio, presence of atoms at the edges of surface, enhanced bioactivity and sensitivity. This chapter presents an overview of different types of nanoparticles used for protein separation , purification and detection applications. In addition, accounts on industrial applications of nanoparticles for protein bioseparation and future reflections are discussed.

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Authors and Affiliations

  1. Faculty of Engineering and Science, Department of Chemical Engineering, Curtin University, CDT 250, 98009, Miri, Sarawak, Malaysia

    Jaison Jeevanandam

  2. Department of Chemistry and Biomolecular Science, University of Ottawa, Ontario, k1N6N5, Canada

    Prabir Kumar Kulabhusan

  3. Chemical Engineering Department, University of Tennessee, Chattanooga, TN, 37403, USA

    Michael K. Danquah

Authors
  1. Jaison Jeevanandam
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  2. Prabir Kumar Kulabhusan
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  3. Michael K. Danquah
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Correspondence to Michael K. Danquah .

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  1. SAGE, University of South Carolina, Columbia, SC, USA

    Ravindra Pogaku

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Jeevanandam, J., Kulabhusan, P.K., Danquah, M.K. (2019). Biofunctional Nanoparticles for Protein Separation, Purification and Detection. In: Pogaku, R. (eds) Horizons in Bioprocess Engineering. Springer, Cham. https://doi.org/10.1007/978-3-030-29069-6_7

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