Abstract
Nanobiotechnology application, at the interface of nanocarrier and therapeutic enzyme, holds great promises in the nanomedicine. In this direction, gold nanocarriers contribute a plethora of nanobiotechnological applications due to their unique properties. The salient features of gold nanoparticle include high catalytic activity, unique optical properties, ease of surface functionalization, biocompatibility and long-period stability. The potential use of gold nanoparticle in conjunction with therapeutic enzymes can be further extended for curing many dreadful diseases.
We reviewed the suitability of gold nanocarrier-bound therapeutic enzyme delivery in biomedical modality, in particular to therapeutic application. The major health issues such as cancer, cardiovascular disease and brain disease are regulated with the intervention of gold nanoparticle-bound therapeutic enzyme delivery. Gold nanocarrier-bound therapeutic enzyme has increased the pharmacokinetic and pharmacodynamic correlation in drug delivery. Therapeutic fungal asparaginase covalently immobilized on the surface of gold nanoparticles demonstrated higher cytotoxicity effect against lung cancer and ovarian cell lines. It is further demonstrated that the gold nanoparticle-bound asparaginase has increased its bioavailability up to 85% more against lung cancer. The serratiopeptidase-bound gold nanoparticle has considerably increased anti-inflammatory response. The present chapter is concluded with recent literature discussion that gold nanoparticle-bound therapeutic enzyme has broadened the scope of traditional therapeutics to effective therapeutic enzyme delivery.
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The authors would like to thank the director of the Indian Institute of Information Technology Una for providing the necessary facility to carry out nanobiotechnology work.
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Verma, M.L., Kumar, P., Sharma, S., Dhiman, K., Sharma, D., Verma, A. (2020). Gold Nanoparticle-Mediated Delivery of Therapeutic Enzymes for Biomedical Applications. In: Daima, H., PN, N., Ranjan, S., Dasgupta, N., Lichtfouse, E. (eds) Nanoscience in Medicine Vol. 1. Environmental Chemistry for a Sustainable World, vol 39. Springer, Cham. https://doi.org/10.1007/978-3-030-29207-2_3
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