Skip to main content

Nepal: A Global Hotspot for Medicinal Orchids

  • Chapter
  • First Online:
Medicinal Plants

Abstract

Floristic diversity of family Orchidaceae in Nepal (area 147,181 sq. km) is impressive, as 517 species under 105 genera have been reported so far. Orchidaceae is one of the largest families in plant kingdom with abundant scientific studies carried out on their phytochemistry, and available bioactive compounds but with insufficient potential medicinal research and applications. Since the ancient Vedic period dating back to 2500 BCE, orchids have been mentioned widely for their medicinal use in traditional medical system of Ayurveda. Ancient scripts like Rig-Veda contain the preparation methods of formulations using orchids in combination with other herbs and their healing powers. Some of the compounds identified for their bioactivity are alkaloids, anthraquinones, cardiac glycosides, flavonoids, glycosides, phlobatanins, quercetin, reducing sugars, saponins, steroids, and terpenoids. There are numerous studies on ethnobotanical uses of orchids found in Nepal. In this chapter, medicinal properties of a total of 130 species are discussed; several of these species have been tested for their chemical constituents, in vitro properties and in vivo clinical efficacy. Unfortunately, orchids in their natural habitats are disappearing at an alarming rate. There is an immediate need to conserve orchids in their natural habitats at local, national, and international levels. This situation coupled with climate change poses grave challenges to the efforts to understand their medicinal properties.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Acharya KP (2018) Orchids of Nepal checklist. http://nepaliorchids.blogspot.com/p/orchid-of-nepal-checklist.html. Accessed 9 March 2018

  • Acharya KP, Rokaya MB (2010) Medicinal orchids of Nepal: are they well protected? Our Nat 8:82–91

    Article  Google Scholar 

  • Ahmed F, Sayeed A, Islam A et al (2001) Characterization and in vitro antimicrobial activity of 17–hydroxy-14, 20-epoxy-1-oxo-[22R]-3-[O-d-glucopyranosyl]-5, 24-withadienolide from Vanda Roxburghii. Br Sci 1:324–326

    Google Scholar 

  • Anonymous (1983) Nepali brihat sabdakosh. Royal Nepal Academy, Kathmandu

    Google Scholar 

  • Arditti J (1992) Fundamentals of orchid biology. Wiley, New York

    Google Scholar 

  • Arditti J (1993) Micropropagation of orchids. Wiley, New York

    Google Scholar 

  • Arora M, Mahajan A, Sembi J (2017) A review of phytochemical and pharmacological potential of family Orchidaceae. Intl Res J Pharm 8:9–24

    Article  CAS  Google Scholar 

  • ASP (2013) Dynamic changes of main active ingredients in A. roxburghii (wall.) Lindl. and A. formosanus in different growth stages

    Google Scholar 

  • Baas P, Veldkamp JF (2013) Dutch pre-colonial botany and Rumphius’s Ambonese herbal. Allertonia 13:9–19

    Google Scholar 

  • Bailes (1985) Orchids of Nepal: the conservation and development of natural resources. Advisory report and recommendation. RBG, Kew

    Google Scholar 

  • Balami NP (2004) Ethnomedicinal uses of plants among the Newar community of Pharping village of Kathmandu district. Nepal Tribhuvan Univ J 24:13–19

    Article  Google Scholar 

  • Banarji ML (1978) Orchids of Nepal. Today and Tomorrow’s Publisher, New Delhi

    Google Scholar 

  • Banerji ML, Pradhan P (1984) The orchids of Nepal Himalaya. J Cramer, Germany

    Google Scholar 

  • Bao XS, Shun QS, Chen LZ (2001) The medicinal plants of Dendrobium (Shi-Hu) in China, a coloured atlas. Fudan Uni Press, Shanghai. (in Chinese)

    Google Scholar 

  • Baral SR, Kurmi PP (2006) A compendium of medicinal plants of Nepal. Mass Printing Press, Kathmandu, Nepal

    Google Scholar 

  • Barnette M (1992) A garden of words. Times Book, New York

    Google Scholar 

  • Basu K, Das GB, Bhattacharya SK et al (1971) Anti-inflammatory principles of Vanda roxburghii. Curr Sci 40:86–87

    CAS  Google Scholar 

  • Berliocchi L (2004) The orchid in lore and legend. Timber Press, Portland, OR

    Google Scholar 

  • Bhandari SR, Kapadi AH, Mujumder PL et al (1985) Nudol, a phenanthrene of the orchids Eulophia nuda, Eria carinata and Eria stricta. Phytochemistry 24(4):801–804

    Article  CAS  Google Scholar 

  • Bhatnagar M, Ghosal S (2018) Antibacterial and antimycobacterial activity of medicinal orchid of Arunachal Pradesh. Int J Pharm Sci Res 9(2):712–717. https://doi.org/10.13040/IJPSR.0975-8232.9(2).712-17

    Article  CAS  Google Scholar 

  • Bhatnagar M, Sarkar N, Gandharv N et al (2017) Evaluation of antimycobacterial, leishmanicidal and antibacterial activity of three medicinal orchids of Arunachal Pradesh, India. BMC Complem Alternative Med 17:379

    Article  CAS  Google Scholar 

  • Bhattacharjee B, Islam SMS (2015) Assessment of antibacterial and antifungal activities of the extracts of Rhyncostylis retusa Blume—A medicinal orchid. World J Pharm Pharm Sci 4(2):74–87

    Google Scholar 

  • Bi ZM, Wang ZT et al (2003) Studies on the chemical constituents of Dendrobium fimbriatum. Yao Xue Xue Bao 38:526–529

    CAS  PubMed  Google Scholar 

  • Biswas S, Pardeshi R, Reddy ND et al (2016) Bulbophyllum sterile petroleum ether fraction induces apoptosis in vitro and ameliorates tumor progression in vivo. Biomed Pharmacother 84:1419–1427

    Article  CAS  PubMed  Google Scholar 

  • Bulpitt CJ (2005) The use and misuse of orchids in medicine. Q J Med 98:625–631

    Article  CAS  Google Scholar 

  • Bulpitt CJ, Li Y, Bulpitt PF et al (2007) The use of orchids in Chinese medicine. J Royal Soc Med 100:558–563

    Article  Google Scholar 

  • Campbell MW (1983) Plant propagation for reforestation in Nepal, Rev. Ed, Nepal-Australia Forestry Project, Dept. of Forestry, Australian Nat Uni, Canberra

    Google Scholar 

  • Chand MB, Paudel MR, Pant B (2016) The antioxidant activity of selected wild orchids of Nepal. J Coastal Life Med 4(9):731–736

    Article  CAS  Google Scholar 

  • Chaudhary RP (1998) Biodiversity in Nepal: status and conservation. Craftsman Press, Bangkok

    Google Scholar 

  • Chaudhary R, Uprety Y, Rimal S (2015) Deforestation in Nepal: Causes, consequences and responses. Biological and Environmental hazards, risks and disasters. In: Hazards and disaster series. pp 335–372

    Google Scholar 

  • Chauhan NS (1990) Medicinal orchids of Himachal Pradesh. J Orchid Soc India 4:99–105

    Google Scholar 

  • Chauhan NS (1999) Medicinal and aromatic plants of Himachal Pradesh. Indus Publishing Company, New Delhi

    Google Scholar 

  • Chen Y, Xu J, Yu H et al (2007a) 3,7-Dihydroxy-2,4,6-trimethoxyphenanthrene, a new phenanthrene from Bulbophyllum odoratissimum. J Korean Chem Soc 51:352

    Article  CAS  Google Scholar 

  • Chen Y, Xu J, Yut H et al (2007b) Bulbophyllum odoratissimum 3,7-Dihydroxy-2,4,6-trimethoxyphenanthrene. J Korean Chem Soc 51:352–355

    Article  CAS  Google Scholar 

  • China Tea Review (2012) Herbal tea: dendrobium flower tea. http://www.chinateareview.com. Accessed 24 Sept 2018

  • Chopra RN, Nair SL, Chopra IC (1956) Glossary of Indian medicinal plants. PID, New Delhi

    Google Scholar 

  • da Silva JAT, Acharya KP (2014) In Vitro propagation of Nepalese orchids: a review. J Hort Res 22(2):47–52

    Google Scholar 

  • Darwin C (1862) On the various contrivances by which British and foreign orchids are fertilised by insects. John Murray, London

    Google Scholar 

  • Dash B, Sharma RK (2015) Caraka Samhita. Vol. 1. Chaukhamba Sanskrit Series, India

    Google Scholar 

  • Dash PK, Sahoo S, Subhasisa B (2008) Ethnobotanical studies on orchids of Niyamgiri Hill ranges, Orissa, India. Ethnobot Leaflets 12:70–78

    Google Scholar 

  • DFRS (1999) Forest and shrub cover of Nepal 1994 (1989–1996). Dept of Forest Research and Survey, Kathmandu, Nepal

    Google Scholar 

  • DPR (2001) Flowering plants of Nepal (Phanerogams), HMG Ministry of Forests and Soil Conservation. Dept Plant Res, Kathmandu, Nepal

    Google Scholar 

  • Dresseler RL (1982) The orchids: natural history and classification. Harvard University Press, Boston

    Google Scholar 

  • Fan C, Wang W, Wang Y et al (2001) Chemical constituents from Dendrobium densiflorum. Phytochemistry 57:1255–1258

    Article  CAS  PubMed  Google Scholar 

  • Garha M (2017) Health care in Nepal: an observational perspective. J Nursing Edu Practice 7(1):114–117

    Google Scholar 

  • Gewali MB (2008) Aspects of traditional medicine in Nepal. Institute of National Medicine. Univ of Toyama, Toyama, Japan

    Google Scholar 

  • Giri D, Tamta S (2010) A general account on traditional medicinal uses of Dactylorhiza hatagirea (D. Don) Soo. NY Sci J 3:78–79

    Google Scholar 

  • GoN (2008) Stocktaking report on biodiversity: national capacity self-assessment for global environment management. Ministry of Environ, Sci Tech, Kathmandu, Nepal

    Google Scholar 

  • Gong YQ, Fan Y, Wu DZ et al (2004) In vivo and in vitro evaluation of erianin, a novel antiangiogenic agent. Eur J Cancer 40:1554–1565

    Article  CAS  PubMed  Google Scholar 

  • Govaerts R, Bernet P, Kratochvil K et al (2017) World checklist of Orchidaceae. Kew: Royal Botanic Gardens. http://apps.kew.org/wcsp/. Accessed 3 Sept 2018

  • Gutiérrez RMP (2010) Orchids: a review of uses in traditional medicine, its phytochemistry and pharmacology. J Med Plant Res 4(8):592–638

    Google Scholar 

  • Hamilton FB (1819) An account of the Kingdom of Nepal, and of the territories annexed to this dominion by the house of Gorkha. Archibald Constable and Company, London

    Google Scholar 

  • Hamilton FB, Don D (1824) Prodromus Florae Nepalensis. J. Gale, London

    Google Scholar 

  • Hara H, Stearn WT, Williams WT et al (1978) An enumeration of the flowering plants of Nepal, vol 1. Trustees of the British Museum (Natural History), London

    Google Scholar 

  • He C, Wang C, Guo S, Yang J, Xiao P (2006) A novel flavonoid glucoside from Anoectochilus roxburghii (Wall.) Lindl. J Integr Plant Biol 48:359–363

    Article  CAS  Google Scholar 

  • Heo JC, Woo SU, Son M et al (2007) Antitumor activity of Gastrodia elata Blume is closely associated with a GTP-Ras dependent pathway. Oncol Rep 8:849–853

    Google Scholar 

  • Hinsley A, de Boer HJ, Fay MF et al (2017) A review of the trade in orchids and its implications for conservation. Bot J Linn Soc 186:435–455

    Article  Google Scholar 

  • Hooker JD (1855) Himalayan journals. Notes of a naturalist. Today and tomorrow’s Publishers, Delhi

    Google Scholar 

  • Hossain MM (2011) Therapeutic orchids: traditional uses and recent advances—an overview. Fitoterapia 82:102–140

    Article  PubMed  Google Scholar 

  • Ikeda Y, Nonaka H, Furumai T et al (2005) Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata. J Nat Prod 68:572–573

    Article  CAS  PubMed  Google Scholar 

  • Jalal J, Kumar P, Pangtey YPS (2008) Ethnomedicinal orchids of Uttarakhand, Western Himalaya. Ethnobotl Leaf 12:1227–1230

    Google Scholar 

  • Jana SK, Sinha GP, Chauhan NS (1997) Ethnobotanical aspects of orchids of Sikkim. J Orchid Soc India 11:79–84

    Google Scholar 

  • Joshi G, Tewari LM, Lohani N et al (2009) Diversity of orchids on Uttarakhand and their conservation strategy with special reference to their medicinal importance. Rep Opinion 1:47–52

    Google Scholar 

  • Kafle G (2011) An overview of shifting cultivation with reference to Nepal: Review. Intl J Biod Cons 3(5):147–154

    Google Scholar 

  • Karnick CR (1996) Pharmacology of Ayurvedic medicinal plants, Indian Medical Sciences Series, vol 47. Sri Satguru Publications, Delhi, India

    Google Scholar 

  • Kaushik P (1983) Ecological and anatomical marvels of the Himalayan orchids. Today and Tomorrow’s Printers and Publishers, New Delhi

    Google Scholar 

  • Khasin SM, Rao PRM (1999) Medicinal importance of orchids. The Botanica 49:86–91

    Google Scholar 

  • Khory N (1982) Materia medica of India and their therapeutics. Neeraj Publishing House, Delhi, India

    Google Scholar 

  • Kirtikar KR, Basu BD (1935) Indian medicinal plants, vol III. Lalit Mohan Basu, Allahabad

    Google Scholar 

  • Kizu H, Kaneko EI, Tomimori T (1999) Studies on Nepalese crude drugs. XXVI. Chemical constituents of Panchaunle, the roots of Dactylorhiza hatagirea D. Don. Chem Pharm Bull 47(11):1618–1625

    Article  CAS  Google Scholar 

  • Kumar V, Choedon T (2013) Medicinal plant used in the practice of Tibetan medicine. In: Govil GN (ed) Recent progress in medicinal plants, potential and challenges. Stadium Press, USA

    Google Scholar 

  • Kumar PKS, Subramoniam A, Pushpangadan (2000) Aphrodisiac activity of Vanda tessellata (Roxb.) Hook. Ex Don extract in male mice. Indian J Pharm 32:300–304

    Google Scholar 

  • Lad V (1996) Ayurveda: the science of self-healing. Lotus Press, Santa Fe

    Google Scholar 

  • Lam Y, Ng TB, Yao RM et al (2015) Evaluation of chemical constituents and important mechanism of pharmacological biology in Dendrobium plants. Evid Based Compliment Alternative Med 2015:841752. https://doi.org/10.1155/2015/841752

    Article  Google Scholar 

  • Lama YC, Ghimire SK, Aumeeruddy-Thomas Y (2001) Medicinal plants of Dolpo: Amchis’ knowledge and conservation. WWF, Kathmandu, Nepal

    Google Scholar 

  • Landon P (1928) Nepal. Constable, London

    Google Scholar 

  • Lawler LJ (1984) Ethnobotany of the Orchidaceae. In: Orchid biol rev Perspect iii. Comstock Publ. Associates, Ithaca, NY & London, UK, pp 27–149

    Google Scholar 

  • Lee YH, Park JD, Baek NI et al (1995) In vitro and in vivo antitumoral phenanthrenes from the aerial parts of Dendrobium nobile. Planta Med 61:178–180

    Article  CAS  PubMed  Google Scholar 

  • Li YM, Wang HY, Liu GQ (2001) Erianin induces apoptosis in human leukemia HL-60 cells. Acta Pharm Sin 22:1018–1022

    CAS  Google Scholar 

  • Lin YL, Wang WY, Kuo YH et al (2001) Homocyclotirucallane and two dihydrophenanthrenes from Spiranthes sinensis. Chem Pharm Bull 49(9):1098–1101

    Article  CAS  Google Scholar 

  • Liu MF, Han Y, Xing DM et al (2004) A new stilbenoid from Arundina graminifolia. Asian Nat Prod Res 6(3):229–232

    Article  CAS  Google Scholar 

  • Liu MF, Ding Y, Zhang DM (2005a) Phenanthrene constituents from rhizome of Arundina graminifolia. Zhongguo Zhong Yao Za Zhi 30(5):353–356

    CAS  PubMed  Google Scholar 

  • Liu MF, Han Y, Xing DM et al (2005b) One new benzyldihydrophenanthrene from Arundina graminifolia. Asian Nat Prod Res 7(5):767–770

    Article  CAS  Google Scholar 

  • Liu H, Feng C-L, Luo Y-B et al (2010) Potential challenges of climate change to orchid conservation in a wild orchid hotspot in southwestern China. Bot Rev 76:174–192

    Article  Google Scholar 

  • Long P, Long C (2006) In: Bin X, Zhongming C, Zhongten G (eds) Medicinal orchids in China in ethnobotany and medicinal plants. East-South University Press, Nanjing

    Google Scholar 

  • Loukas M, Lanteri A, Ferrauiola J et al (2010) Anatomy in ancient India: a focus on the Susruta Samhita. Rev J Anat 217:646–650

    Article  Google Scholar 

  • Lüning B (1964) Studies on Orchidaceae alkaloids I, screening of species for alkoloids 1. Acta Chem Scand 18:1507–1518

    Article  Google Scholar 

  • Luning B, Leander KK (1965) Studies on orchidaceous alkaloids III. Acta Chem Scand 19:1607–1611

    Article  CAS  Google Scholar 

  • Majumder PL, Maiti DC (1988) Flaccidin, a 9,10-dihydrophenanthropyran derivative from the orchid Coelogyne flaccida. Phytochemistry 27(3):899–901. https://doi.org/10.1016/0031-9422(88)84115-3

    Article  CAS  Google Scholar 

  • Majumder PL, Pal S (1993) Cumulatin and tristin, two bibenzyl derivatives from the orchids Dendrobium cumulatum and Bulbophyllum triste. Phytochemistry 32(6):1561–1565. https://doi.org/10.1016/0031-9422(93)85180-Y

    Article  CAS  Google Scholar 

  • Majumder PL, Sen RC (1991) Bulbophyllanthrone, a phenanthraquinone from Bulbophyllum odoratissimum. Phytochemistry 30:2092–2094. https://doi.org/10.1016/0031-9422(91)85078-E

    Article  CAS  Google Scholar 

  • Majumder PL, Kar A, Shoolery JN (1985) Bulbophyllanthrin, a phenanthrene of the orchid Bulbophyllum leopardium. Phytochemistry 24(9):2083–2087. https://doi.org/10.1016/S0031-9422(00)83127-1

    Article  CAS  Google Scholar 

  • Majumder PL, Banerjee S, Maiti DC (1995) Stilbenoids from the orchids Agrostophyllum callosum and Coelogyne flaccida. Phytochemistry 39(3):649–653

    Article  CAS  Google Scholar 

  • Majumder PL, Banerjee S, Sen S (1996) Three stilbenoids from the orchid Agrostophyllum callosum. Phytochemistry 42(3):847–852. https://doi.org/10.1016/0031-9422(95)00954-X

    Article  CAS  Google Scholar 

  • Majumder P, Roychowdhury M, Chakraborty S (1998) Thunalbene, a stilbene derivative from the orchid Thunia alba. Phytochemistry 49(8):2375–2378

    Article  CAS  Google Scholar 

  • Majumder PL, Sen S, Banerjee S (1999) Agrostophyllol and isoagrostophyllol, two novel diastereomeric 9,10-dihydrophenanthropyran derivatives from the orchid Agrostophyllum callosum. Tetrahedron 55(21):6691–6702

    Article  CAS  Google Scholar 

  • Majumder PL, Sen S, Majumder S (2001) Phenanthrene derivatives from the orchid Coelogyne cristata. Phytochemistry 58(4):581–586

    Article  CAS  PubMed  Google Scholar 

  • Malla SB, Shakya PR (1984) Medicinal plants of Nepal. In: Majupuria TC (ed) Nepal Nature’s paradise. White Lotus, Bangkok, pp 261–297

    Google Scholar 

  • Manandhar (1993) Ethnobotanical notes on folk lore remedies of Baglung district, Nepal. Contribut Nepalese Stud 20(2):183–196

    Google Scholar 

  • Manandhar NP (2002) Plants and people of Nepal. Timber Press, Oregon, USA

    Google Scholar 

  • Marasini R, Joshi S (2012) Antibacterial and antifungal activity of medicinal orchids growing in Nepal. J Nep Chem Soc 29:104–109

    Article  CAS  Google Scholar 

  • Maridassa M, Zahir Hussain MI, Raju G (2008) Phytochemical survey of orchids in the Tirunelveli hills of South India. Ethnobot Leaflets 12:705–712

    Google Scholar 

  • Marjoka A, Alam O, Huda MK (2016) Phytochemical screening of three medicinally important epiphytic orchids of Bangladesh. J Biol Sci 5(1):95–99

    Google Scholar 

  • Matsuda H, Morikawa T, Xie H et al (2004) Antiallergic phenanthrenes and stilbenes from the tubers of Gymnadenia conopsea. Planta Med 70(9):847–855

    Article  CAS  PubMed  Google Scholar 

  • Medhi RP, Chakrabarty S (2009) Traditional knowledge of NE people on conservation of wild orchids. Indian J Tradit Knowl 8(1):11–16

    Google Scholar 

  • Mikage M, Komastsu K, Takano A et al (1988) A list of Tibetan crude drugs stored in the museum of materia medica research institute for Wakan-Yaku, Toyama medical and pharmaceutical university. In: Namba T (ed) Tibetan medicine and materia medica. Res Inst Wakan-Yaku, Toyama Med Pharma Uni, pp 89–106

    Google Scholar 

  • Mishra AP, Saklani S (2012) Satyrium nepalense: a rare medicinal orchid of western Himalaya (India); phytochemical screening, antimicrobial evaluation and conservation studies. Indonesian J Pharm 23(3):162–170

    Google Scholar 

  • Mishra AP, Saklani S, Parcha V et al (2014) A developed and validated high performance thin-layer chromatographic method for the quantitative determination of quercetin in Satyrium nepalense tubers. J Planar Chromatogr 6:444–448

    Article  CAS  Google Scholar 

  • Mitra A, Sur TK, Upadhyay S et al (2017) Effect of Swarna Jibanti (Coelogyne cristata L.) in alleviation of chronic fatigue syndrome in aged Wistar rats. J Ayurveda Integr Med 9(4):266–271. https://doi.org/10.1016/j.jaim.06.011

    Article  PubMed  PubMed Central  Google Scholar 

  • Miyazawa M, Shimamura H, Nakamura SI et al (1997) Antimutagenic activity of gigantol from Dendrobium nobile. J Agric Food Chem 45(8):2849–2853

    Article  CAS  Google Scholar 

  • Miyazawa M, Shimamura H, Nakamura et al (1999) Moscatilin from Dendrobium nobile, a naturally occurring bibenzyl compound with potential antimutagenic activity. J Agric Food Chem 47:2163–2167

    Article  CAS  PubMed  Google Scholar 

  • Moerman D (1998) Native American ethnobotany. Timber Press, Oregon

    Google Scholar 

  • Molvray M (1988) Tibetan medicine: a glossary for the study of Tibetan medicinal plants. Series 11. Library of Tibetan Works and Archives. CBT, New Delhi, India

    Google Scholar 

  • Morningstar A (1994) The Ayurvedic cookbook. Motilal Banarsidass Publishers, Delhi

    Google Scholar 

  • Nayak BS, Suresh R, Rao AV et al (2005) Evaluation of wound healing activity of Vanda roxburghii R. Br. (Orchidaceae): a preclinical study in a rat model. Int J Low Extrem Wounds 4(4):200–204

    Article  CAS  PubMed  Google Scholar 

  • Nguyen VD, Nhu D (1989) Medicinal plants in Vietnam. WHO, Geneva

    Google Scholar 

  • Panda AK, Mandal D (2013) The folklore medicinal orchids of Sikkim. Anc Sci Life 33(2):92–96

    PubMed  PubMed Central  Google Scholar 

  • Pant B (2013) Medicinal orchids and their uses: tissue culture a potential alternative for conservation. African J Plant Sci 7(10):448–467

    Article  Google Scholar 

  • Pant B (2015) Our orchid conservation effort in two community forests of Central Nepal. In: Orchid Conservation News: The Newsletter of the Orchid Specialist Group of the IUCN SSC

    Google Scholar 

  • Pant B, Raskoti BB (2013) Medicinal orchids of Nepal. Himalayan Map House, Kathmandu, Nepal

    Google Scholar 

  • Pant B, Thapa D (2012) In vitro mass propagation of an epiphytic orchid, Dendrobium primulinum Lindl. through shoot tip culture. African J Biotech 11(42):9970–9974

    CAS  Google Scholar 

  • Parmar G, Acharya R (2016) In vitro seed germination of endangered Nepalese orchid species: Dendrobium fimbriatum Hook. Adv J Seed Sci Tech 3(1):72–74

    Google Scholar 

  • Paudel MR, Pant B (2017) Cytotoxic activity of crude extracts of Dendrobium amoenum and detection of bioactive compounds by GC-MS. Botan Orient: J Plant Sci 11:38–42

    Article  Google Scholar 

  • Paudel R, Upadhyaya T, Pahari DP (2012) People’s perspective on access to health care services in a rural district of Nepal. J Nep Med Assoc 52(1):20–24

    CAS  Google Scholar 

  • Paudel MR, Chand MB, Karki N et al (2015) Antioxidant activity and total phenolic and flavonoid contents of Dendrobium amoenum Wall. ex Lindl. Botan Orient 9:20–26

    Article  Google Scholar 

  • Paul P, Chowdhury A, Nath D et al (2013) Antimicrobial efficacy of orchid extracts as potential inhibitors of antibiotic resistant strains of Escherichia coli. Asian J Pharma Clin Res 6(3):108–111

    Google Scholar 

  • Pohle P (1990) Useful plants of Manag district. A contribution to the ethnobotany of Nepal Himalaya. Franzsteiner Verlag, Stuttgart

    Google Scholar 

  • Prasad DN, Achari G (1966) A study of anti-arthritic action of Vanda roxburghii in albino rats. J Indian Med Assoc 46(5):234–237

    CAS  PubMed  Google Scholar 

  • Prasad R, Koch B (2014) Antitumor activity of ethanolic extract of Dendrobium formosum in T-cell lymphoma: an in vitro and in vivo study. Biomed Res Int 2014:753451

    PubMed  PubMed Central  Google Scholar 

  • Prasad R, Koch B (2016) In vitro anticancer activities of ethanolic extracts of Dendrobium crepidatum and Dendrobium chrysanthum against T-cell lymphoma. J Cytol Histol 7:4. https://doi.org/10.4172/2157-7099.1000432

    Article  CAS  Google Scholar 

  • Pyakurel D, Gurung K (2008) Enumeration of orchids and estimation of current stock of traded orchids in Rolpa district: final report. DFO Rolpa, Rolpa, Nepal

    Google Scholar 

  • Rajbhandary KR (2015) A handbook of the orchids of Nepal. DPR, Kathmandu, Nepal

    Google Scholar 

  • Ramesh T, Renganathan P (2016) Study on antimicrobial, anti-inflammatory, antitumor activity of some medicinal orchids- a review. Intl J Res Instinct 3(2):161–169

    Google Scholar 

  • Rao RSK (1985) Encyclopaedia of Indian medicine: historical perspective, Vol. 1. Popular Prakashan, New Delhi

    Google Scholar 

  • Rashmi K, Shweta SD, Sudeshna CS et al (2015) Antibacterial and radical scavenging activity of selected orchids of Karnataka, India. Sci Tech Arts Res J 4(1):160–164

    Article  CAS  Google Scholar 

  • Raskoti BB (2009) The orchids of Nepal quality printers Kathmandu, Nepal

    Google Scholar 

  • Rokaya MB, Raskoti BB, Timsina B et al (2013a) An annotated checklist of the orchids of Nepal. Nor J Bot 31(5):511–550

    Article  Google Scholar 

  • Rokaya MB, Uprety Y, Paudel RC et al (2013b) Traditional uses of medicinal plants in gastrointestinal disorders in Nepal. J Ethnopharmacol 158:221–229

    Article  Google Scholar 

  • Roy AR, Patel RS, Patel VS et al (2007) Medicinal orchids of Meghalaya. J Orchid Soc India 21:15–17

    Google Scholar 

  • Sachdev K, Kulshreshtha DK (1986) Phenolic constituents of Coelogyne ovalis. Phytochemistry 25(2):499–502. https://doi.org/10.1016/S0031-9422(00)85509.

    Article  CAS  Google Scholar 

  • Saklani A, Jain SK (1994) Cross-cultural ethnobotany of Northeast India. Deep Publications, New Delhi

    Google Scholar 

  • Shakya LR, Bajracharya DM, Chettri MK (1994) Conserving the threatened orchids of Kathmandu Valley. Report Series 8. WWF Nepal Program, Kathmandu, Nepal

    Google Scholar 

  • Shanavaskhan AE, Sivadasan M, Alfarhan AH et al (2012) Ethnomedicinal aspects of angiospermic epiphytes and parasites of Kerala, India. Indian J Tradit Knowl 11(2):250–258

    Google Scholar 

  • Shapoo GA, Kaloo ZA, Ganie AH et al (2013) Ethnobotanical survey and documentation of some orchid species of Kashmir Himalaya, J&K-India. Intl J Pharma Biol Res 4(2):32–42

    Google Scholar 

  • Shimura H, Matsuura M, Takada N et al (2007) An antifungal compound involved in symbiotic germination of Cypripedium macranthos var. rebunense (Orchidaceae). Phytochemistry 68:1442–1447

    Article  CAS  PubMed  Google Scholar 

  • Shriram V, Kumar V, Kavi Kishor PB et al (2010) Cytotoxic activity of 9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol from Eulophia nuda against human cancer cells. J Ethnopharmacol 128(1):251–253

    Article  CAS  PubMed  Google Scholar 

  • Shweta SD, Sudeshna CS, Rashmi K et al (2015) Antifungal efficacy of some epiphytic orchids of Karnataka, India. Scholars J Agric Vet Sci 2(3B):266–269

    Google Scholar 

  • Singh DK (2001) Morphological diversity of the orchids of Orissa. In: Pathak P, Sehgal RN, Shekhar N et al (eds) Orchids: science and commerce. BSMPS, New Delhi, India

    Google Scholar 

  • Singh AP (2006a) Dhanwantri Nighantu. Chaukhambha Orientalia, New Delhi

    Google Scholar 

  • Singh AP (2006b) Raj Nighantu. Chaukhambha Orientalia, New Delhi

    Google Scholar 

  • Singh A, Duggal S (2009) Medicinal orchids-an overview. Ethnobot Leaf 1:13

    CAS  Google Scholar 

  • Singh AP, Sandhu AS (2005) A dictionary of medicinal plants. Singhal, S. Sundeep Publishers, New Delhi

    Google Scholar 

  • Singh DR, Kishore R, Kumar R et al (2016) Orchid preparations: Tech bull 00. ICAR, Nat Res Center for Orchids, Sikkim

    Google Scholar 

  • Subedi A (2002) Orchids around Pokhara valley of Nepal. LI-BIRD occasional paper no. 1. Pokhara, Nepal

    Google Scholar 

  • Subedi A, Subedi N, Chaudhary RP (2007) Panchase Forest: an extraordinary place for wild orchids in Nepal. Pleoine 1:23–31

    Google Scholar 

  • Subedi A, Kunwar B, Choi Y et al (2013) Collection and trade of wild-harvested orchids in Nepal. J Ethnobiol Ethnomed 9:64

    Article  PubMed  PubMed Central  Google Scholar 

  • Sutton S (1978) Plant collectors in Nepal. In: Hara H (ed) An enumeration of the flowering plants of Nepal, vol 1. Trustees of the British Museum (Natural History), London, pp 13–21

    Google Scholar 

  • Teja J, Naroop PD, Sumanth N et al (2012) Anti-diarrhoeal activity of petroleum ether extract of Vanda tessellata leaves on castor oil induced diarrhea in rats. Int J Phytopharm Res 3(2):99–102

    Google Scholar 

  • Teoh ES (2016) Medicinal orchids of Asia. Springer, Switzerland

    Book  Google Scholar 

  • Tezuka Y, Ji L, Hirano H et al (1990) Studies on the constituents of orchidaceous plants IX constituents of Spiranthes sinensis (Pers.) Ames var. amoena (M. Bieberson [M. Bieberstein]) Hara.(2): structures of spiranthesol, spiranthoquinone, spiranthol-C and spiransineol-B, new isopentenyldihydrophenanthrenes. Chem Pharm Bull 38:629–635

    Article  CAS  Google Scholar 

  • Thakur M, Dixit VK (2007) Aphrodisiac activity of Dactylorhiza hatagirea (D. Don) Soo in male albino rats. Evidence-Based Compl Alter Med 4:29–31

    Article  Google Scholar 

  • Thakur RB, Yadav RP, Thakur NP (2010) Enumerating the status of orchid species of Makawanpur district. Hamro Kalpabricha 20:1–18

    Google Scholar 

  • Thapa L (2009) The research project on edible wild plants of Bhutan and their associated traditional knowledge. J Fac Agric Shinshu Uni 45(1):43–48

    Google Scholar 

  • Tiwari AP, Joshi B, Ansari AA (2012) Less known ethnomedicinal uses of some orchids by the tribal inhabitants of Amarkantak Plateau, Madhya Pradesh. India Nat Sci 10(12):33–37

    Google Scholar 

  • Vaidya BD (1991) Materia Medica of Ayurveda, Based on Madanpala’s Nighantu. Jain Publishers, New Delhi, India

    Google Scholar 

  • Vaidya BN, Shrestha M, Joshee N (2002) Report on Nepalese orchids species with medicinal properties. In: Watanabe T, Takano A, Bista MS, Saiju HK (ed) Proceedings of Nepal-Japan joint symposium on conservation and utilization of Himalayan medicinal resources, Kathmandu

    Google Scholar 

  • Venkateswarlu S, Satyanarayana B, Sureshbabu CV et al (2003) Synthesis and antioxidant activity of 4-[2-(3,5-Dimethoxyphenyl)ethenyl]-1,2-benzenediol, a metabolite of Sphaerophysa salsula. Biosci Biotechnol Biochem 67(11):2463–2466

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Guan SH, Meng YH et al (2013) Phenanthrenes, 9,10-dihydrophenanthrenes, bibenzyls with their derivatives, and malate or tartrate benzyl ester glucosides from tubers of Cremastra appendiculata. Phytochemistry 94:268–276

    Article  CAS  PubMed  Google Scholar 

  • Wang X, Chen X, Yang P et al (2017) Barcoding the Dendrobium (Orchidaceae) species and analysis of the intragenomic variation based on the internal transcribed spacer. Biomed Res Int 2:1–10

    CAS  Google Scholar 

  • Watanabe T, Rajbhandari KR, Malla KJ et al (2005) A handbook of medicinal plants of Nepal. Kobfai Publishing Project, Bangkok

    Google Scholar 

  • WECS (2013) Energy sector synopsis report Nepal-2013. Water and Energy Commission Secretariat, Kathmandu

    Google Scholar 

  • Wilson MF (2007) Medicinal plant fact sheet: Cypripedium: Lady’s slipper orchids. A collaboration of the IUCN medicinal plant specialist group, PCA-medicinal plant working group, and North American pollinator protection campaign, Arlington, Virginia

    Google Scholar 

  • Xia WB, Xue Z, Li S et al (2005) Chemical constituents from tuber of Cremastra appendiculata. Zhongguo Zhong Yao Za Zhi 30:1827–1830

    CAS  PubMed  Google Scholar 

  • Xu J, Yu H, Qing C et al (2009) Two new biphenanthrenes with cytotoxic activity from Bulbophyllum odoratissimum. Fitoterapia 80(7):381–384

    Article  CAS  PubMed  Google Scholar 

  • Xue Z, Li S, Wang S et al (2006) Mono-, Bi-, and Triphenanthrenes from the tubers of Cremastra appendiculata. J Nat Prod 69(6):907–913. https://doi.org/10.1021/np060087n

    Article  CAS  PubMed  Google Scholar 

  • Yamaki M, Honda C (1996) The stilbenoids from Dendrobium plicatile. Phytochemistry 43(1):207–208. https://doi.org/10.1016/0031-9422(96)00270-1

    Article  CAS  Google Scholar 

  • Yan L, Chun-Lan W, Shun-Xing G et al (2008) Four new bibenzyl derivatives from Dendrobium candidum. Chem Pharm Bull 56:1477–1479

    Article  Google Scholar 

  • Yang L, Qin LH, Bligh SW et al (2006) A new phenanthrene with a spirolactone from Dendrobium chrysanthum and its anti-inflammatory activities. Bioorg Med Chem 14:3496–3501

    Article  CAS  PubMed  Google Scholar 

  • Yang SY, Wang SG, Li HL et al (2013) Research status of identification on CAULIS DENDROBII. J Anhui Agric Sci 41:1495–1497

    CAS  Google Scholar 

  • Yonzone R, Lama D, Bhujel RB et al (2012a) Terrestrial and semi saprophytic orchid species diversity of Darjeeling Himalaya of West Bengal, India. McAllen Int Orchid Soc J 13(4):2–20

    Google Scholar 

  • Yonzone R, Kamran A, Bhujel RB (2012b) Orchids in ethnobotany. Proceeding, volume, Int. Sem on multidis. Appr Angiosp. System 2:661–669

    Google Scholar 

  • You HL, Park JD, Baek NI et al (1995) In vitro and in vivo antimural phenanthrenes from the aerial parts of Dendrobium nobile. Planta Med 61:178–180

    Article  Google Scholar 

  • Yu S, Wang Z, Su Z et al (2018) Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells. BMC Complement Altern Med 18:59

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zha XQ, Luo JP, Wei P (2009) Identification and classification of Dendrobium candidum species by fingerprint technology with capillary electrophoresis. SA J Bot 75:276–282

    Article  CAS  Google Scholar 

  • Zhan HD, Zhou HY, Sui YP et al (2016) The rhizome of Gastrodia elata Blume An ethnopharmacological review. J Ethnopharmacol 189:361–385

    Article  CAS  PubMed  Google Scholar 

  • Zhang JH, Guo SX, Yang JS (1999) Studies on chemical constituents of the fungus accelerating the growth of Anoectochilus roxburghii. Chin Pharm J 34:800–802. (in Chinese with an English abstract)

    CAS  Google Scholar 

  • Zhao W, Ye Q, Tan X et al (2001) Three new sesquiterpene glycosides from Dendrobium nobile with immunomodulatory activity. J Nat Prod 64:1196–2000

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

Thank you to Dr. Nirmal Joshee, for providing constant support and mentorship, and helping me finish this chapter, the idea of which originated 20 years ago. Thanks to late Professor Michael Wirth, from my undergraduate years at New England College, Henniker, New Hampshire, who introduced me to the wonderful world of orchids.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Brajesh Nanda Vaidya .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Vaidya, B.N. (2019). Nepal: A Global Hotspot for Medicinal Orchids. In: Joshee, N., Dhekney, S., Parajuli, P. (eds) Medicinal Plants. Springer, Cham. https://doi.org/10.1007/978-3-030-31269-5_3

Download citation

Publish with us

Policies and ethics