Abstract
Alzheimer’s disease (AD) precipitation in the elderly population increases the need for sensitive biomarkers that can be applied to large population screening. Buccal cells can be obtained easily, noninvasively, and contain many proteins related to cerebral processes. Hence, they offer an ideal candidate for AD biomarker discovery. The purpose of this study is to provide an overview of the current research landscape covering both clinical and methodological issues. A brief summary is given on related laboratory techniques to ascertain protein concentration changes due to AD. At the end, we describe a protocol designed in our laboratory for disease early diagnosis.
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Acknowledgments
Τhe research work was supported by the Hellenic Foundation for Research and Innovation (HFRI) and the General Secretariat for Research and Technology (GSRT), under the HFRI PhD Fellowship grant (GA. no. 2096).
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Avramouli, A., Vlamos, P. (2020). Buccal Mucosa Biomarkers in Alzheimer’s Disease. In: Vlamos, P. (eds) GeNeDis 2018. Advances in Experimental Medicine and Biology, vol 1195. Springer, Cham. https://doi.org/10.1007/978-3-030-32633-3_8
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DOI: https://doi.org/10.1007/978-3-030-32633-3_8
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