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Emerging Food Allergy Therapies

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Pediatric Food Allergy

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Abstract

Many exciting food allergy therapies, including allergen-specific and non-specific treatment techniques, are currently under clinical investigation. The most well-studied treatment modality is food immunotherapy, which comes in several types including oral (OIT), epicutaneous (EPIT), and sublingual (SLIT). As a follow-up to the prior discussions on OIT and EPIT, this chapter focuses on emerging therapies that are earlier in development. With its growing body of evidence, this chapter begins with a general overview of SLIT, including its proposed mechanism of action, efficacy, and side effects. Advantages and disadvantages of SLIT when compared to OIT and EPIT are also highlighted. Other food-specific therapies reviewed in this chapter include peptide-based vaccines, recombinant allergen vaccines, allergen DNA vaccinations, and transgenic plants, which have less supportive clinical study data available but which present exciting possible treatment modalities. Studies evaluating the use of non-allergen-specific therapies in the treatment of food allergy, including anti-IgE treatment (used as monotherapy or as an adjunct to food-specific therapies), traditional Chinese medicine, and probiotics are also reviewed. Finally, understanding that food immunotherapy may become a standard part of clinical practice in the very near future, this chapter concludes with a discussion about patient-specific factors and preferences for the clinician to consider when deciding on the optimal treatment modality for an individual patient.

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Authors and Affiliations

  1. University of North Carolina at Chapel Hill, Department of Pediatrics, Division of Allergy, Immunology, and Rheumatology, Chapel Hill, NC, USA

    Luanna Yang

  2. University of North Carolina at Chapel Hill, Department of Medicine, Division of Rheumatology, Allergy and Immunology, Chapel Hill, NC, USA

    Edwin H. Kim

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  1. Luanna Yang
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  2. Edwin H. Kim
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Correspondence to Edwin H. Kim .

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  1. Center for Food Allergy and Asthma Research, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Ruchi S. Gupta

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Yang, L., Kim, E.H. (2020). Emerging Food Allergy Therapies. In: Gupta, R. (eds) Pediatric Food Allergy . Springer, Cham. https://doi.org/10.1007/978-3-030-33292-1_19

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