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Thyroid Hormone Signaling Mechanisms in the Heart and Vasculature

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Thyroid and Heart

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Abstract

Thyroid hormones regulate cardiac development, and in the adult, these hormones play key roles in cardiac growth, metabolism, and function. The complexity of thyroid hormone signaling in the cell has recently come into sharper focus with reports of functional thyroid hormone receptors localized in the cytosolic, mitochondrial, and membrane-associated compartments as well as the nucleus. Thus, categorizing thyroid hormone action as genomic or non-genomic will require revision. This review presents a broad overview of known mechanisms of action of these hormones in the heart and vasculature with a discussion of effects on cardiac function and vascular reactivity in normal and diseased settings.

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The authors declare that they have no conflicts of interest regarding the content discussed in this review article.

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  1. Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, USA

    Kaie Ojamaa & Maria Alicia Carrillo-Sepulveda

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  1. Kaie Ojamaa
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  1. Institute of Clinical Physiology (IFC) National Research Council (CNR), Pisa, Italy

    Giorgio Iervasi

  2. Institute of Clinical Physiology (IFC) National Research Council (CNR), Pisa, Italy

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  3. NYITCOM College of Osteopathic Medicine Biomedical Sciences Department, Old Westbury, NY, USA

    A.Martin Gerdes

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    Salman Razvi

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Ojamaa, K., Carrillo-Sepulveda, M.A. (2020). Thyroid Hormone Signaling Mechanisms in the Heart and Vasculature. In: Iervasi, G., Pingitore, A., Gerdes, A., Razvi, S. (eds) Thyroid and Heart . Springer, Cham. https://doi.org/10.1007/978-3-030-36871-5_3

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  • DOI: https://doi.org/10.1007/978-3-030-36871-5_3

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-030-36871-5

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