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Genetic Variations and Polymorphisms of Metabolic Enzymes

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Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense

Abstract

Genetic polymorphism is a DNA sequence variation, which is common in human population. Genes involved in the biosynthesis of metabolic enzymes are subject to genetic polymorphisms. Enzyme polymorphisms play a critical role in xenobiotic cytotoxicity and carcinogenesis. Genetic differences in drug metabolism are the result of variations in alleles for genes that code for the enzymes responsible for drug metabolism. Genetic polymorphisms presented include cytochrome P450, flavin-containing monooxygenase, peroxidase, and carboxylesterase of activation enzymes, as well as glutathione S-transferase, UDP-glucuronosyltransferase, sulfotransferase, N-acetyltransferase and methyltransferase of transferases, and quinone oxidoreductase and epoxide hydrolase of non-transferases of detoxification enzymes.

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Authors and Affiliations

  1. Institute for Health and the Environment and Department of Biomedical Sciences, University at Albany, State University of New York, 5 University Place, Rensselaer, NY, USA

    Chang-Hwei Chen

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Chen, CH. (2020). Genetic Variations and Polymorphisms of Metabolic Enzymes. In: Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense. Springer, Cham. https://doi.org/10.1007/978-3-030-41679-9_14

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