Abstract
When the heart of a 7-day-old chick embryo is dissociated into its component cells, a majority of those cells (50–60%), completely isolated from contact with neighbors, are capable of spontaneous rhythmic activity when maintained under suitable in vitro culture conditions1*. Any such single isolated cell which is seen to beat must be initiating its own activity, and may thus be defined as a pacemaker2. Moreover, such a cell, within 5–30 min after coming into contact with a more slowly beating neighbor, may cause that neighbor to beat in synchrony with it.
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References
R. L. de Haan, Devel. Biol. 16, 216 (1967).
R. L. de Haan, Factors Influencing Myocardial Contractility (Ed. R. D. Tanz, F. Kavaler and J. Roberts; Academic Press, New York 1967), p. 217.
R. L. de Haan and S. H. Gottlieb, J. gen. Physiol. 52, 643 (1968).
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DeHaan, R.L. (1969). Electrical Recording from Embryonic Heart Cells Isolated in Tissue Culture. In: McCann, F.V. (eds) Comparative Physiology of the Heart: Current Trends. Experientia Supplementum. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6800-6_14
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DOI: https://doi.org/10.1007/978-3-0348-6800-6_14
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