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Recent Advances in Electrophysiology of Antiarrhythmic Drugs

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Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

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Abstract

In this review, we are concerned with the most recent advances in single cell cardiac electrophysiology and pharmacology. We have restricted ourselves to research papers that appeared in the 2 years since our last review [1] and additionally certain articles of special interest. The reader is referred to the comprehensive review by SZEKERES and PAPP published in this journal [2] and to the monograph by the same authors for more extensive surveys of the many actions of numerous antiarrhythmic drugs [3]. There also are several recently published reviews and symposia dealing with various aspects of cardiac arrhythmias and therapy [4–12]. We agree with SZEKERES and PAPP [3] that it is almost impossible to completely review the ever increasing number of publications on this subject. One reason for the voluminous literature is the multiple experimental approaches used to attack the problems of arrhythmia formation and the modes of action of antiarrhythmic drugs. Our own approach is based to a great extent on studies utilizing intracellular microelectrode recording techniques [13–15]. This method permits the direct characterization of the electrophysiological properties of single cells in the heart. We will consider and evaluate recent publications concerned with cardiac arrhythmias and antiarrhythmic drugs with particular emphasis on new experimental methods which expand the physiological significance of data obtained through the use of microelectrode recording techniques.

Supported in part by NHLI Grant 12738.

Recipient Career Development Award, NHLI K4-HE-42500.

Senior Investigator of the New York Heart Association.

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  1. Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, N.Y., USA

    Arthur L. Bassett & Andrew L. Wit

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  1. Arthur L. Bassett
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  1. Sandoz AG, Basel, Switzerland

    Ernst Jucker

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Bassett, A.L., Wit, A.L. (1973). Recent Advances in Electrophysiology of Antiarrhythmic Drugs. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques, vol 17. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7084-9_2

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