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The Oxidative Metabolism of Drugs and Other Foreign Compounds

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Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

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Abstract

As many xenobiotics [1] are more soluble in fat than in water, they first must be metabolized in order to allow excretion from the organism. They pass out of the blood plasma with the ultrafiltrate into the renal tubules. There in accordance with the water-lipid solubility ratio of the drug it is either excreted or it penetrates the membranes of the tubular cells. On the same principles, the xenobiotics can cross the membranes of other types of cells. This would lead to a poisoning of the metabolism if it were not for a xenobiotic detoxificating enzyme-system which metabolizes these substances to a more water soluble form [2–4].

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  1. Medizinische Kliniken und Polikliniken, Justus Liebig Universität, 63 Giessen, Federal Republic of Germany

    F. Kratz

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  1. Sandoz AG, Basel, Switzerland

    Ernst Jucker

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Kratz, F. (1973). The Oxidative Metabolism of Drugs and Other Foreign Compounds. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques, vol 17. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7084-9_9

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  • DOI: https://doi.org/10.1007/978-3-0348-7084-9_9

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