Abstract
The extreme sensitivity of diphtheria toxin production to the iron concentration of the medium was clearly shown by Pappenheimer and Johnson [1]. Iron level of the medium, therefore, has to be carefully controlled whether diphtheria toxin is produced using a surface or a submerged culture. However, the mechanism underlying the inhibition of toxin production by iron is not yet known. We have employed a purely synthetic medium, developed by us, to study the effect of iron on the bacillus as well as on toxin production. On the basis of the observations made, we have also put forward a hypothesis to explain the mechanism.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
A. M. Pappenheimer Jr. and S. J. Johnson, Studies in Diphtheria Toxin Production. I. The Effect of Iron and Copper, Br. J. exp. Path. 17, 335–341 (1936).
W. N. M. Ramsay, The Determination of Iron in Blood Plasma or Serum, Biochem. J. 53, 227–231 (1953).
S. K. Sardesai and S. S. Rao, Role of Iron in the Regulation of Toxin Production by C. diphtheriae, Indian J. exp. Biol. 4, 209–211 (1966).
A. M. Pappenheimer Jr., Diphtheria Toxin. III. A Reinvestigation of the Effect of Iron on Toxin and Porphyrin Production, J. Biol. Chem. 167, 251–259 (1947).
H. Sato and I. Kato, Regulatory Mechanisms of the Formation of Diphtheria Toxin. I. Isolation and Property of an Inhibitory Factor, Jap. J. exp. Med. 35, 145–158 (1965).
F. W. Tanner, C. Vojnovich and J. M. Van Lanen, Riboflavin Production by Candida species, Science 101, 180–181 (1945).
H. Katagiri, Symp. Enzyme Chem., Japan 6, 3 (1951) (quoted from Mitsuhashi [9])
M. Suda, Osaka Med. J. 2, 85 (quoted from Mitsuhashi [9]).
S. Mitsuhashi, M. Murakami, K. Yagi and E. Suzuki, On the Production of the Toxin by C. diphtheriae. III. The Conditions of the Formation of Flavin Compounds, Jap. J. exp. Med. 22, 1–7 (1952).
L. Barksdale, C. diphtheriae and Its Relatives, Bact. Rev. 234, 378 (1970).
E. A. Sickles and W. M. O’leary, Production of a Toxin Counterpart by Nontoxigenic C. diphtheriae, Proc. Soc. exp. Biol. Med. 128, 1051–1055 (1968).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Birkhäuser Verlag Basel
About this chapter
Cite this chapter
Gadre, S.V., Rao, S.S. (1975). Iron and Diphtheria Toxin Production. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 19. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7090-0_32
Download citation
DOI: https://doi.org/10.1007/978-3-0348-7090-0_32
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-0348-7092-4
Online ISBN: 978-3-0348-7090-0
eBook Packages: Springer Book Archive