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Some unsolved problems with vaccines

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Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

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Abstract

There must surely be general agreement with Dick [1] that “the development of immunisation has been one of the most striking features in the control of infectious disease in the twentieth century”. Yet concern must be expressed in 1979, the International Year of the Child, that immunization against the major childhood diseases reaches less than 10% of children in developing countries [2], and that in South-East Asia alone an estimated 3 million children die every year before reaching the age of 12 months although about half of these deaths could have been prevented by vaccines [3].

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References

  1. G. Dick: Immunisation, p. 2 (and Preface), 3, 9, 13, 14, 69, 102. Update Books, London 1978.

    Google Scholar 

  2. The Lancet: A healthy start. Lancet 1, 394 (1979).

    Google Scholar 

  3. World Health Organization: Full support demanded for immunization in the South-East Asia Region. WHO Chron. 32, 455–456 (1978).

    Google Scholar 

  4. International Conference of Primary Health Care: Declaration of Alma-Ata. World Health, WHO Magazine, p. 28–29, November 1978.

    Google Scholar 

  5. J. A. Davis: Declaration of Alma-Ata. Lancet 2, 1144 (1978).

    Google Scholar 

  6. T.C. Beard: Declaration of Alma-Ata. Lancet 1, 217–218 (1979).

    Article  Google Scholar 

  7. World Health Organization: A year without smallpox in Africa. WHO Chron. 32, 483 (1978).

    Google Scholar 

  8. World Health Organization: Smallpox vaccination for travellers no longer needed, says WHO Commission. WHO Chron. 33, 28 (1979).

    Google Scholar 

  9. R. W. Smithells: Social class, health, and initiative. Lancet 1, 272 (1979).

    Article  Google Scholar 

  10. N.W. Preston and T.N. Stanbridge: Efficacy of pertussis vaccines: a brighter horizon. Br. Med. J. 3, 448–451 (1972).

    Article  Google Scholar 

  11. N.W. Preston: Prevalent serotypes of Bordetella pertussis in non-vaccinated communities. J. Hyg., Camb. 77, 85–91 (1976).

    Article  Google Scholar 

  12. T. Kuronen and R. Huovila: Seroresponse to pertussis vaccine. Recent advances in pertussis research, p. 4–5. International Association of Biological Standardization, Conches 1978.

    Google Scholar 

  13. A.C. Blaskett, J. Gulasekharam and L. C. Fulton: The occurrence of Bordetella pertussis serotypes in Australia, 1950–1970. Med. J. Aust. 1, 781–784 (1971).

    Google Scholar 

  14. F.W. Sheffield, A.G. Ironside and J.D. Abbott: Immunisation of adults against diphtheria. Br. Med. J. 2, 249–250 (1978).

    Article  Google Scholar 

  15. J.D. Abbott, A.G. Ironside and F.W. Sheffield: Immunisation of adults against diphtheria. Br. Med. J. 2, 1371 (1978).

    Google Scholar 

  16. I. Lönnroth, J. Holmgren and S. Lange: Chlorpromazine inhibits cholera toxin-induced intestinal hypersecretion. Med. Biol. 55, 126–129 (1977).

    Google Scholar 

  17. R. Freter and G. W. Jones: Adhesive properties of Vibrio cholerae: nature of the interaction with intact mucosal surfaces. Infect. Immun. 14, 246–256 (1976).

    Google Scholar 

  18. N.W. Preston: La patogenicità dei vibrioni colerici quale guida al trattamento e alla prevenzione. Clinica e Laboratorio 2, 93–109 (1978).

    Google Scholar 

  19. S. Toma, H. Lo and M. Magus: Bordetella pertussis serotypes in Canada. Can. Med. Ass. J. 119, 722–724 (1978).

    Google Scholar 

  20. D.M. Mel, B.L. Arsić, B.D. Nikolić and M.L. Radovanić: Studies on vaccination against bacillary dysentery. 4. Oral immunization with live monotypic and combined vaccines. Bull. Wld Hlth Org. 39, 375–380 (1968).

    Google Scholar 

  21. J.M. Miler, J.F. Spilsbury, R.J. Jones, E.A. Roe and E.J.L. Lowbury: A new polyvalent Pseudomonas vaccine. J. Med. Microbiol. 10, 19–27 (1977).

    Article  Google Scholar 

  22. N. W. Preston: Vaccine composition in relation to antigenic variation of the microbe: is pertussis unique? Prog. Drug Res. 19, 347–355 (1975).

    Google Scholar 

  23. W.C. Hsieh and B.S. Hsieh: Immune responses in cholera vaccinated persons. J. Formosan Med. Ass. 75, 183–189 (1976).

    Google Scholar 

  24. Philippines Cholera Committee: A controlled field trial of the effectiveness of monovalent classical and El Tor cholera vaccines in the Philippines. Bull. Wld Hlth Org. 49, 13–19(1973).

    Google Scholar 

  25. B. Guhathakurta, D. Sasmal, G.C. Datta and A. Datta: Immunological studies on the ammonium sulphate fractions of Vibrio cholerae cell lysate. Indian J. exp. Biol. 16, 569–572 (1978).

    Google Scholar 

  26. N. W. Preston: Mechanisms of pathogenicity in man and animals. Soc. gen. Microbiol. Proc. 4, 6 (1976–7).

    Google Scholar 

  27. N.F. Pierce, E.A. Kaniecki and R. S. Northrup: Protection against experimental cholera by antitoxin. J. infect. Dis. 126, 606–616 (1972).

    Article  Google Scholar 

  28. M. N. Guentzel and L. J. Berry: Protection of suckling mice from experimental cholera by maternal immunization: comparison of the efficacy of whole-cell, ribosomal-derived, and enterotoxin immunogens. Infect. Immun. 10, 167–172(1974).

    Google Scholar 

  29. N.W. Preston and T.N. Stanbridge: Mouse or man? Which are pertussis vaccines to protect? J. Hyg., Camb. 76, 249–256 (1976).

    Article  Google Scholar 

  30. F.T. Perkins: Control testing of pertussis vaccine. Recent advances in pertussis research, p. 24–25. International Association of Biological Standardization, Conches 1978.

    Google Scholar 

  31. J. Cameron: Pertussis vaccine control-testing problems. Recent advances in pertussis research, p. 26–27. International Association of Biological Standardization, Conches 1978.

    Google Scholar 

  32. J. H. L. Playfair: Why doesn’t the immune system protect us against parasites? Lab-Lore (The Wellcome Foundation Ltd) 8, 515–516 (1978).

    Google Scholar 

  33. D.E.S. Stewart-Tull, T. Shimono, S. Kotani, M. Kato, Y. Ogawa, Y. Yama-mura, T. Koga and C.M. Pearson: The adjuvant activity of a non-toxic, water-soluble glycopeptide present in large quantities in the culture filtrate of Mycobacterium tuberculosis strain DT. Immunology 29, 1–15 (1975).

    Google Scholar 

  34. J.S. Saroso, W. Bahrawi, H. Witjaksono, R.L.P. Budiarso, Brotowasisto, Z. Benčić, W.E. Dewitt and C.Z. Gomez: A controlled field trial of plain and aluminium hydroxide-adsorbed cholera vaccines in Surabaya, Indonesia, during 1973–75. Bull. Wld Hlth Org. 56, 619–627 (1978).

    Google Scholar 

  35. J. Cameron and P.A. Knight: Interaction of components of triple antigen (diphtheria, tetanus, pertussis: D.T.P.). Proceedings of Symposium on Combined Vaccines, p. 55–67. Yugoslav Academy of Sciences and Arts, Zagreb 1972.

    Google Scholar 

  36. N. W. Preston: Protection by pertussis vaccine: little cause for concern. Lancet 1, 1065–1067(1976).

    Article  Google Scholar 

  37. N.W. Preston, R.I. Mackay, F.N. Bamford, J.E. Crofts and W.L. Burland: Pertussis agglutinins in vaccinated children: better response with adjuvant. J. Hyg., Camb. 73, 119–125 (1974).

    Article  Google Scholar 

  38. E. Rossier and F. Chan: Bordetella pertussis in the National Capital Region: prevalent serotype and immunization status of patients. Can. Med. Ass. J. 117, 1169–1171(1977).

    Google Scholar 

  39. R.G. Mathias: Whooping cough in spite of immunization. Can. J. Publ. Hlth 69, 130–132(1978).

    Google Scholar 

  40. J. C. Kelsey: The AP Syndrome. Br. Med. J. 4, 104, 360 (1973).

    Article  Google Scholar 

  41. A.H. Griffith: Reactions after pertussis vaccine: a manufacturer’s experiences and difficulties since 1964. Br. Med. J. 1, 809–815 (1978).

    Article  Google Scholar 

  42. J.H.G. Roerink: Differences between agglutinogenic and immunogenic properties of various 45/20 vaccines. Symp. Series Immunobiol. Standard. 12, 43–46. Karger, Basel, New-York 1970.

    Google Scholar 

  43. J.W.G. Smith, J. A. Lee, W.B. Fletcher, C.A. Morris, D.A. Parker, R. Yetts, D.I. Magrath and F.T. Perkins: The response to oral poliovaccine in persons aged 16–18 years. J. Hyg., Camb. 76, 235–247 (1976).

    Article  Google Scholar 

  44. R.S. Northrup, J. Bienenstock and T.B. Tomasi: Immunoglobulins and antibody activity in the intestine and serum in cholera. I. Analysis of immunoglobulins in cholera stool. J. infect. Dis., Suppl. 121, S137-S141 (1970).

    Article  Google Scholar 

  45. M. Church: Return of whooping cough. Br. Med. J. 1, 195 (1979).

    Article  Google Scholar 

  46. D. Gibson: Which medium for the message? World Health, WHO Magazine, p. 20–23, January 1979.

    Google Scholar 

  47. N.W. Preston: Changing advice on vaccination. Br. Med. J. 1, 194–195 (1979).

    Article  Google Scholar 

  48. C.R. Manclark, M.A. Urban, E.P. Summers and J.H. Vickers: Assay of pertussis vaccine toxicity by a rat-paw-oedema method. J. Med. Microbiol. 10, 115–120(1977).

    Article  Google Scholar 

  49. D.L. Miller and E.M. Ross: National childhood encephalopathy study: an interim report. Br. Med. J. 2, 992–993 (1978).

    Article  Google Scholar 

  50. The Lancet: Poliovaccine for parents. Lancet 2, 1030–1031 (1978).

    Google Scholar 

  51. The Lancet: Male oscuro — R.S.V.? Lancet 1, 651–652 (1979).

    Google Scholar 

  52. The Lancet: Progress in gonorrhoea. Lancet 1, 539–540 (1978).

    Google Scholar 

  53. World Health Organization: The people’s war — against disease and for health. WHO Chron. 32, 139 (1978).

    Google Scholar 

  54. World Health Organization: Spiritual health is important. WHO Chron. 33, 29–30(1979).

    Google Scholar 

  55. J.M. Mahieu, A.S. Muller, A.M. Voorhoeve and H. Dikken: Pertussis in a rural area of Kenya: epidemiology and a preliminary report on a vaccine trial. Bull. Wld Hlth Org. 56, 773–780 (1978).

    Google Scholar 

  56. N. W. Preston: Maternal antibody against pertussis. Br. Med. J. 2, 706 (1977).

    Article  Google Scholar 

  57. The Lancet: Acceptance of measles vaccine. Lancet 2, 387–388 (1977).

    Google Scholar 

  58. World Medicine: The force of truth and fact? Wld Med. 14/5, 5 (1978).

    Google Scholar 

  59. World Health Organization: Crying wolf too often? WHO Chron. 32, 142 (1978).

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Bacteriology and Virology, University of Manchester, Manchester, M 13 9PT, England

    Noel W. Preston M.D., Dp.Bact., F.R.C. Path

Authors
  1. Noel W. Preston M.D., Dp.Bact., F.R.C. Path
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Editors and Affiliations

  1. Basel, Switzerland

    Ernst Jucker

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© 1979 Birkhäuser Verlag Basel

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Preston, N.W. (1979). Some unsolved problems with vaccines. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 23. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7105-1_1

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  • DOI: https://doi.org/10.1007/978-3-0348-7105-1_1

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7107-5

  • Online ISBN: 978-3-0348-7105-1

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