Summary
The effects of serotonin (5-HT) and the 5-HT3 receptor antagonist, BRL 24924, on gastric acid and pepsin secretion were evaluated in conscious dogs with a gastric fistula. In accordance with previous studies serotonin inhibited gastric secretion. BRL 24924 possessed both inhibitory and stimulatory effects depending on the background stimulation. The inhibitory effects of serotonin on gastric secretion were counteracted by BRL 24924 only during infusion of pentagastrin, which by itself releases serotonin. 5-HT3 receptors are of minor importance in the control of gastric secretion.
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© 1991 Birkhäuser Verlag Basel/Switzerland
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Johansen, B., Lyngsø, J.M., Bech, K. (1991). The Effects of BRL 24924 (Renzapride) on Secretion of Gastric Acid and Pepsin in Dogs. In: Fozard, J.R., Saxena, P.R. (eds) Serotonin: Molecular Biology, Receptors and Functional Effects. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7259-1_36
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DOI: https://doi.org/10.1007/978-3-0348-7259-1_36
Publisher Name: Birkhäuser Basel
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