Skip to main content
SpringerLink
Log in

Potential gene therapy for alcoholism

  • Chapter
Toward a Molecular Basis of Alcohol Use and Abuse

Part of the book series: Experientia ((EXS,volume 71))

Summary

Genes that have an actual or a potential relationship to alcoholism may he useful targets for therapy. Candidate genes are considered in relationship to family studies, differences in alcohol preferences in various rodent strains, biochemical reactions, physiologic response mechanisms, and alterations in brain pharmacology. Suggestions are made concerning the identification of candidate genes, design of gene antisense constructs, and techniques for their organ-specific delivery. The complexities surrounding alcoholism in humans make it likely that several simultaneous approaches may be required for effective therapy for alcoholism.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Altshuler, H.I., Phillips, P.E. and Feinhandler, D.A. (1980) Alteration of ethanol self-administration by naltrexone. Life Sci. 26: 679–688.

    Article  PubMed  CAS  Google Scholar 

  • Alino, S.F., Bobadilla, M., Garci-Sanz, M., Lejarreta, M., Unda, F. and Hilario, E. (1993) In vivo delivery of human a 1-antitrypsin gene to mouse hepatocytes by liposomes. Biochem. Biophys. Res. Commun. 192: 174–181.

    Article  PubMed  CAS  Google Scholar 

  • Asmussen, E., Hald, J. and Larsen, V. (1948) The pharmacological action of acetaldehyde on human organism. Acta Pharmacol. Toxicol. 4: 311–320.

    Article  CAS  Google Scholar 

  • Barton, N.W., Brady, R.O., Dambrosia, J.M., DiBisceglie, A.M., Doppelt, S.H., Hill, S.C., Mankin, H.J., Murray, G.J., Parker, R.I., Argoff, C.E., Grewal, R.P. and Yu, K.-T. (1991) Replacement therapy for inherited enzyme deficiency–macrophage-targeted glucocerebrosidase for Gaucher’s disease. N. Engl. J. Med. 324: 1464–1470.

    Article  PubMed  CAS  Google Scholar 

  • Brady, R.O. and Furbish, F.S. (1982) Enzyme replacement therapy: specific targeting of exogenous enzymes to storage cells. In: Martonosi, A.N. (ed.): Membranes and Transport, Vol. 2, Plenum Publishing Corp., New York, pp. 587–592.

    Google Scholar 

  • Brady, R.O. and Westerfeld, W.W. (1947) The effect of B-complex vitamins on the voluntary consumption of alcohol by rats. Quart. J. Stud. Alcohol 7: 499–505.

    PubMed  CAS  Google Scholar 

  • Carr, L.G., Mellencamp, R.J., Crabb, D.W., Weiner, H., Lumeng, L. and Li, T.-K. (1991) Polymorphism of the rat liver mitochondrial dehydrogenase cDNA. Alcohol. Clin. Exp. Res. 15: 753–756.

    Article  PubMed  CAS  Google Scholar 

  • Cheng, S.T. and Tseng, L.F. (1982) Chronic administration of ethanol on pituitary and hypo thalamic Ăź-endorphin in rats and golden hamsters. Pharmacol. Res. Commun. 14: 1001–1008.

    Article  PubMed  CAS  Google Scholar 

  • Chrisey, L., Rossi, J. and Sarver, N. (1991) Ribozymes: progress and prospects of catalytic RNA as therapeutic agents. Antisense Res. Develop. 1: 57–63.

    CAS  Google Scholar 

  • Cloninger, C.R., Bohman, M. and Sigvardsson, S. (1981) Inheritance of alcohol abuse. Arch. Gen. Psychiatry 38: 861–868.

    Article  PubMed  CAS  Google Scholar 

  • Crabb, D.W., Edenberg, H.J., Bosron, W.F. and Li, T.-K. (1989) Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH22 allele is dominant. J. Clin. Invest. 83: 314–316.

    Article  PubMed  CAS  Google Scholar 

  • Crooke, S.T. and Lebleu, B. (1993) Antisense Research and Applications. CRC, Boca Raton.

    Google Scholar 

  • Das, P.K., Murray, G.J., Zirzow, G.C., Brady, R.O. and Barranger, J.A. (1985) Lectin-specific targeting of Ăź-glucocerebrosidase to different liver cells via glycosylated liposomes. Biochem. Med. 33: 124–131.

    Article  PubMed  CAS  Google Scholar 

  • Eriksson, K. (1969) The estimation of heritability for the self-selection of alcohol in the albino rat. Ann. Med. Exp. Biol. Fenn. 47: 172–174.

    PubMed  CAS  Google Scholar 

  • Fadda, F., Mosca, E., Colombo, G. and Gessa, G.L. (1989) Effect of spontaneous ingestion of ethanol on brain dopamine metabolism. Life Sci. 44: 281–287.

    Article  PubMed  CAS  Google Scholar 

  • Froehlich, J.C. and Li, T.-K. (1990) Enkephalinergic involvement in voluntary alcohol drinking. In: Reid, I. (ed.): Opioids, bulemia, alcohol abuse and alcoholism. Springer-Verlag, New York, pp. 217–238.

    Google Scholar 

  • Froehlich, J.C., Zweifel, M., Harts, J., Lumeng, L. and Li, T.-K. (1991) Importance of delta opioid receptors in maintaining high alcohol drinking. Psychopharmacol. 103: 467–472.

    Article  CAS  Google Scholar 

  • Gauvin, D.V., Moore, K.R. and Holloway, F.A. (1993) Do rat strain differences in ethanol consumption reflect differences in ethanol sensitivity of the preparedness to learn? Alcohol 10: 37–43.

    Article  PubMed  CAS  Google Scholar 

  • Goodwin, D.W., Schulsinger, F., Hermansen, L., Guze, S.B. and Winokur, G. (1973) Alcohol problems in adoptees raised apart from alcoholic biological parents. Arch. Gen. Psychiatry 28: 238–243.

    Article  PubMed  CAS  Google Scholar 

  • Hempel, J., von Bahr-Lindström, H. and Jörnvall, H. (1985) Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations. Eur. J. Biochem. 153: 13–28.

    Article  PubMed  CAS  Google Scholar 

  • Hsu, L.C., Tani, K., Fujiyoshi, T., Kurachi, K. and Yoshida, A. (1985) Cloning of cDNA’s for human aldehyde dehydrogenases 1 and 2. Proc. Natl. Acad. Sci. USA 82: 3771–3775.

    Article  PubMed  CAS  Google Scholar 

  • Hsu, L.C., Bendel, R.E. and Yoshida, A. (1988) Genomic structure of the human mitochondrial aldehyde dehydrogenase gene. Genomics 2: 57–65.

    Article  PubMed  CAS  Google Scholar 

  • Li, T.-K., Lumeng, L., McBride, W.J. and Waller, M.B. (1981) Indiana selection studies on alcohol-related behavior. In: McClearn, G.E., Dietrich, R.A. and Erwin, V.G. (eds.): Development of Animal Models as Pharmacogenetic Tools. NIAAA Research Monograph No. 6. U. S. Department of Health and Human Services, Rockville, MD, pp. 171–191.

    Google Scholar 

  • Li, T.-K., Lumeng, L., Doolittle, D.P. and Carr, L.G. (1991) Molecular associations of alcohol-seeking behavior in rat lines selectively bred for high and low voluntary ethanol drinking. Alcohol Alcohol. Suppl. 1: 121–124.

    CAS  Google Scholar 

  • Lisitsyn, N., Lisitsyn, N. and Wigler, M. (1993) Cloning the differences between two complex genomes. Science 259: 946–951.

    Article  PubMed  CAS  Google Scholar 

  • Lisziewicz, J., Sun, D., Metelev, V., Zamecnik P., Gallo, R.C. and Agarwal, S. (1993) Longterm treatment of human immunodeficiency virus-infected cells with antisense oligonucleotide phosphorothioates. Proc. Natl. Acad. Sci. USA 90: 3860–3964.

    Article  PubMed  CAS  Google Scholar 

  • Mardones, R.J. and Onfray, B.E. (1942) Influencia de una substancia de la levadura (elemonto del complejo vitamfnico B?) sobre el consumo de alcohol en ratas en experimentos de autoseleccibn. Rev. Med. Aliment. Chile (1942) 5: 148–149.

    Google Scholar 

  • Mardones, J. and Segovia-Riquelme, N. (1983) Thirty-two years of selection of rats for ethanol preference: UChA and UChB strains. Neurobehay. Toxicol. Teratol. 5: 171–178.

    CAS  Google Scholar 

  • Michael, S.I., Huand, C.-H, Remer, M.U., Wagner, E., Huii, P.-C. and Curiel, D.T. (1993) Binding-incompetent adenovirus facilitates molecular conjugate-mediated gene transfer by the receptor-mediated endocytosis pathway. J. Biol. Chem. 268: 6866–6869.

    PubMed  CAS  Google Scholar 

  • Mizoi, Y., Ijiri, I., Tatsuno, Y., Kijima, T., Fujiwara, S. and Adachi, J. (1979) Relationship between facial flushing and blood acetaldehyde levels aafter alcohol intake. Pharmacol. Biochem. Behay. 10: 303–311.

    Article  CAS  Google Scholar 

  • Murray, J.A.H. (1992) Antisense RNA and DNA. A.R. Liss, New York.

    Google Scholar 

  • Myers, R.M. (1993) The pluses of subtraction. Science 259: 942–943.

    Article  PubMed  CAS  Google Scholar 

  • Rezvani, A.H., Overstreet, D.H. and Janowsky, D.S. (1990) Genetic serotonin deficiency and alcohol preference in the fawn hooded rats. Alcohol Alcohol. 25: 573–575.

    PubMed  CAS  Google Scholar 

  • Schultz, R., Wuster, M., Duka, T. and Herz, A. (1980) Acute and chronic ethanol treatment changes endrophin levels in brain and pituitary. Psychopharmacol. 68: 221–227.

    Article  Google Scholar 

  • Schwitters, S.Y., Johnson, R.C., Johnson, S.B. and Ahern, F.M. (1982) Familial resemblances in flushing following alcohol use. Behay. Genet. 12: 349–352.

    Article  CAS  Google Scholar 

  • Seizinger, B.R., Bovermann, K., Maysinger, D., Hollt, V. and Herz, A. (1983) Differential effects of acute and chronic ethanol treatment on particular opioid peptide systems in discrete regions of rat brain and pituitary. Pharmacol. Biochem. Behay. 18: 361–369.

    Article  CAS  Google Scholar 

  • Sinclair, J.D. and Lindros, K.O. (1981) Suppression of alcohol drinking with brain aldehyde dehydrogenase inhibition. Pharmacol. Biochem. Behay. 14: 377–383.

    Article  CAS  Google Scholar 

  • Thomasson, H.R., Crabb, D.W., Edenberg, H.J. and Li, T.-K. (1993) Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism. Behay. Genet. 23: 131–136.

    Article  CAS  Google Scholar 

  • Wu, G.T. and Wu, C.H. (1987) Receptor-mediated in vitro gene transformation by a soluble DNA carrier system. J. Biol. Chem. 262: 4429–4432.

    PubMed  CAS  Google Scholar 

  • Yoshida, A., Huang, I.-Y. and Ikawa, M. (1984) Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc. Natl. Acad. Sci. USA 81: 258–261.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Roscoe O. Brady

Authors
  1. Roscoe O. Brady
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Psychiatry, Karolinska Institutet, Huddinge University Hospital, S-141 86, Huddinge, Sweden

    B. Jansson

  2. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77, Stockholm, Sweden

    H. Jörnvall

  3. Department of Clinical Neuroscience, Karolinska Institutet, S-171 76, Stockholm, Sweden

    U. Rydberg  & L. Terenius  & 

  4. Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Seeley G. Mudd Building, 250 Longwood Avenue, 02115, Boston, MA, USA

    B. L. Vallee

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Birkhäuser Verlag Basel/Switzerland

About this chapter

Cite this chapter

Brady, R.O. (1994). Potential gene therapy for alcoholism. In: Jansson, B., Jörnvall, H., Rydberg, U., Terenius, L., Vallee, B.L. (eds) Toward a Molecular Basis of Alcohol Use and Abuse. Experientia, vol 71. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7330-7_38

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-7330-7_38

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7332-1

  • Online ISBN: 978-3-0348-7330-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation