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Trophic Factors and the Control of Smooth Muscle Development and Innervation

  • Chapter
Airways Smooth Muscle: Development, and Regulation of Contractility

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

Abstract

Most studies on autonomic innervation of smooth muscle have focused on the short-term mechanisms involved in neurotransmission in physiological and pathophysiological conditions. However recent observations of the long-term plasticity of this system, i.e. its capacity for regeneration and for compensatory change in pattern of innervation and expression of cotransmitters and receptors in ageing, following surgery, trauma or in disease, have indicated that an understanding of the mechanisms involved could influence the design of therapeutic regimes.

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Authors and Affiliations

  1. Department of Anatomy and Developmental Biology, University College London, London, England

    Pamela Milner & Geoffrey Burnstock

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  1. Pamela Milner
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  2. Geoffrey Burnstock
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  1. Discovery Biology, RhĂ´ne-Poulenc Rorer Ltd, Dagenham Research Centre, RM10 7XS, Dagenham, Essex, England

    David Raeburn (Department Head) (Department Head)

  2. Department of Thoracic Medicine, Royal Brompton National Heart and Lung Institute, Dovehouse Street, SW3 6LY, London, England

    Mark A. Giembycz (Lecturer) (Lecturer)

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© 1994 Birkhäuser Verlag Basel/Switzerland

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Milner, P., Burnstock, G. (1994). Trophic Factors and the Control of Smooth Muscle Development and Innervation. In: Raeburn, D., Giembycz, M.A. (eds) Airways Smooth Muscle: Development, and Regulation of Contractility. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7408-3_1

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  • DOI: https://doi.org/10.1007/978-3-0348-7408-3_1

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7410-6

  • Online ISBN: 978-3-0348-7408-3

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