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Presence, Formation and Function of Ubiquinones Q6 and Q8 in Filarial Parasites

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Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications

Part of the book series: Molecular and Cell Biology Updates ((MCBU))

Summary

Setaria digitate, a cattle filarial parasite reported to be very similar to parasites causing human filariasis shows cyanide insensitive oxygen uptake with the resultant production of H2O2. The production of the latter is associated with the generation of ATP. It is known to be a ubiquinone mediated process. Setaria has two quinones Q6 and Q8 in place of one higher quinone in host systems, thus opening up a very vulnerable target in the parasite.

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Authors and Affiliations

  1. Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581, India

    R. Kaleysa Raj

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  1. R. Kaleysa Raj
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Editor information

Editors and Affiliations

  1. Malaysian Palm Oil Promotion Council, Bangunan Getah Asli 148 Jalan Ampang, 50450, Kuala Lumpur, Malaysia

    A. S. H. Ong

  2. Dept. of Molecular and Cell Biology 251 Life Science Addition, Membrane Bioenergetics Group, Berkeley, California, 94720, USA

    L. Packer

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© 1992 Birkhäuser Verlag, Basel/Switzerland

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Raj, R.K. (1992). Presence, Formation and Function of Ubiquinones Q6 and Q8 in Filarial Parasites. In: Ong, A.S.H., Packer, L. (eds) Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7432-8_33

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  • DOI: https://doi.org/10.1007/978-3-0348-7432-8_33

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7434-2

  • Online ISBN: 978-3-0348-7432-8

  • eBook Packages: Springer Book Archive

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