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Interactions between the ACE and the endothelin pathway

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ACE Inhibitors

Part of the book series: Milestones in Drug Therapy MDT ((MDT))

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Abstract

Endothelin-1 (ET-1) is released from endothelial cells (EC) following gene activation of preproET mRNA and the subsequent proteolytic processing into biologically active peptide [1]. ET-1 activates ETB receptors on EC, promoting the release of endothelium-derived relaxing factor (EDRF), and ETA and ETB receptors on vascular smooth muscle cells (VSMC), promoting events coupled to both vasoconstriction and growth [2]. Activation of ETA/ETB receptors by ET-1 results in activation of the effector enzyme, phospholipase C (PLC) through a Gq-coupled receptor with the subsequent production of the hydrolytic products 1,4,5 inositol-trisphosphate (IP3) and diacylglycerol (DAG) [2]. These mediators subsequently promote [Ca2+]i release from sarcoplasmic reticulum (SR) stores and activate protein kinase C (PKC) respectively.

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Authors and Affiliations

  1. Department of Pharmacology and the Cardiovascular Risk Factor Reduction Unit (CRFRU), College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada

    Rob L. Hopfner, J. Robert McNeill & Venkat Gopalakrishnan

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  1. Rob L. Hopfner
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  2. J. Robert McNeill
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  3. Venkat Gopalakrishnan
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  1. Department of Pharmacology, Institute of Pharmacology of Sherbrooke, Medical School, Sherbrooke University, J1H-5N4, Sherbrooke, PQ, Canada

    Pedro D’Orléans-Juste  & Gérard E. Plante  & 

  2. Departments of Medicine (Nephrology), Physiology and Pharmacology, Institute of Pharmacology, University of Sherbrooke, Sherbrooke, Québec, Canada

    GĂ©rard E. Plante

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© 2001 Birkhäuser Verlag/Switzerland

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Hopfner, R.L., McNeill, J.R., Gopalakrishnan, V. (2001). Interactions between the ACE and the endothelin pathway. In: D’Orléans-Juste, P., Plante, G.E. (eds) ACE Inhibitors. Milestones in Drug Therapy MDT. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7579-0_4

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  • DOI: https://doi.org/10.1007/978-3-0348-7579-0_4

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-7581-3

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