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Phospholipase A2 and remodeling in inflammatory cells

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Arachidonate Remodeling and Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

For many years, lipids were long thought to be merely the bricks and mortar that composed cell membranes. However, in the past 20 years it has become evident that these molecules are not merely passive building blocks but contain information that can be unleashed when they are metabolized upon cell activation. The signaling properties of specific glycerophospholipids and their metabolites highlight the importance of lipid composition in cell homeostasis. For example, phospholipid to sterol ratios are tightly maintained and the loss of these ratios is thought to contribute to foam cell death and the progression of atherosclerosis [1, 2]. Different cell types not only vary in the relative abundance of each phospholipid class, but also in the fatty acyl composition within each class of phospholipids [3, 4].

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Virginia Commonwealth University, Box 980614, Richmond, VA, 23298-0614, USA

    Salma Al-Darmaki

  2. Department of Biochemistry, Virginia Commonwealth University, Box 980614, Richmond, VA, 23298-0614, USA

    Suzanne E. Barbour & Alex D. Manguikian

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  1. Suzanne E. Barbour
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  2. Salma Al-Darmaki
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  3. Alex D. Manguikian
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Editors and Affiliations

  1. Molecular Neurology Program, Huntington Medical Research Institutes, 99 North El Molino Avenue, Pasadena, CA, 91101-1830, USA

    Alfred N. Fonteh

  2. Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157-1016, USA

    Robert L. Wykle

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Barbour, S.E., Al-Darmaki, S., Manguikian, A.D. (2004). Phospholipase A2 and remodeling in inflammatory cells. In: Fonteh, A.N., Wykle, R.L. (eds) Arachidonate Remodeling and Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7848-7_2

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  • DOI: https://doi.org/10.1007/978-3-0348-7848-7_2

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9594-1

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